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pro vyhledávání: '"Barrett M. Powell"'
Autor:
Linda Yingqi Lin, Sawyer McCarthy, Barrett M. Powell, Yanti Manurung, Irene M. Xiang, William L. Dean, Brad Chaires, Liliya A. Yatsunyk, Michel M Ouellette
Publikováno v:
PLoS ONE, Vol 15, Iss 11 (2020)
The G-quadruplex (GQ) is a well-studied non-canonical DNA structure formed by G-rich sequences found at telomeres and gene promoters. Biological studies suggest that GQs may play roles in regulating gene expression, DNA replication, and DNA repair. S
Externí odkaz:
https://doaj.org/article/c04cf5d979e245c7bcf91bd7ad7c2e09
Publikováno v:
Nature Protocols.
Publikováno v:
Nature protocols.
Single-particle cryogenic electron microscopy (cryo-EM) has emerged as a powerful technique to visualize the structural landscape sampled by a protein complex. However, algorithmic and computational bottlenecks in analyzing heterogeneous cryo-EM data
Autor:
Sawyer McCarthy, Barrett M. Powell, Linda Yingqi Lin, Irene M. Xiang, Brad Chaires, Liliya A. Yatsunyk, William L. Dean, Yanti Manurung
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 11, p e0241513 (2020)
PLoS ONE, Vol 15, Iss 11, p e0241513 (2020)
The G-quadruplex (GQ) is a well-studied non-canonical DNA structure formed by G-rich sequences found at telomeres and gene promoters. Biological studies suggest that GQs may play roles in regulating gene expression, DNA replication, and DNA repair. S
Autor:
Nishita Shastri, Jonathan Schug, Yu Chen Tsai, Piyush Borole, Sharvin Shah, Dillon Maloney, Yancy Lo, Taehyong Kim, Kevin D. Smith, Eric J. Brown, Theonie Anastassiadis, Kanika Asija, Suzanne E. Hile, Barrett M. Powell, Deondre Jordan, Xiang Wang, Liliya A. Yatsunyk, Marei Dose, Kristin A. Eckert, Darren Finn, Osvaldo D. Rivera, Jessica Chen, Rafael Casellas
DNA polymerase stalling activates the ATR checkpoint kinase, which in turn suppresses fork collapse and breakage. Herein, we describe use of ATR inhibition (ATRi) as a means to identify genomic sites of problematic DNA replication in murine and human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dac3cca72941da07835b0650a04a1ae
https://europepmc.org/articles/PMC6407864/
https://europepmc.org/articles/PMC6407864/
Autor:
Barrett M. Powell, Cole P. Harbeck, Piotr Habdas, Thomas L. Ruan, Liliya A. Yatsunyk, Supriya J. Davis, Jan Habdas
Publikováno v:
Biochimie. 132
Ligands that stabilize non-canonical DNA structures called G-quadruplexes (GQs) might have applications in medicine as anti-cancer agents, due to the involvement of GQ DNA in a variety of cancer-related biological processes. Five derivatives of 5,10,