Personal model-assisted identification of NAD(+) and glutathione metabolism as intervention target in NAFLD

Autor: Mardinoglu , Adil, Bjornson , Elias, Zhang , Cheng, Klevstig , Martin, Söderlund , Sanni, Ståhlman , Marcus, Adiels , Martin, Hakkarainen , Antti, Lundbom , Nina, Kilicarslan , Murat, Hallström , Björn M, Lundbom , Jesper, Verges , Bruno, Barrett , Peter Hugh R, Watts , Gerald F, Serlie , Mireille J, Nielsen , Jens, Uhlén , Mathias, Smith , Ulf, Marschall , Hanns-Ulrich, Taskinen , Marja-Riitta, Boren , Jan

Publikováno v: Molecular systems biology, 13(3). Wiley-Blackwell
Molecular Systems Biology
Molecular Systems Biology, EMBO Press, 2017, 13, pp.916. 〈http://msb.embopress.org/content/13/3/916〉. 〈10.15252/msb.20167422〉
Molecular Systems Biology, EMBO Press, 2017, 13, pp.916. ⟨10.15252/msb.20167422⟩

IF 10.5; International audience; To elucidate the molecular mechanisms underlying non-alcoholic fatty liver disease (NAFLD), we recruited 86 subjects with varying degrees of hepatic steatosis (HS). We obtained experimental data on lipoprotein fluxes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::370c1b2e3401f0c11db252e43c6e51dd
https://pure.amc.nl/en/publications/personal-modelassisted-identification-of-nad-and-glutathione-metabolism-as-intervention-target-in-nafld(64c4114c-5913-4181-b678-32fc3347beb3).html

Personal model-assisted identification of NAD ⁺ and glutathione metabolism as intervention target in NAFLD.

Autor: Mardinoglu A; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden adilm@scilifelab.se jan.boren@wlab.gu.se.; Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden., Bjornson E; Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden.; Department of Molecular and Clinical Medicine, University of Gothenburg, and Sahlgrenska University Hospital, Gothenburg, Sweden., Zhang C; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden., Klevstig M; Department of Molecular and Clinical Medicine, University of Gothenburg, and Sahlgrenska University Hospital, Gothenburg, Sweden., Söderlund S; Research programs Unit, Diabetes and Obesity, Helsinki University Hospital, University of Helsinki, Helsinki, Finland., Ståhlman M; Department of Molecular and Clinical Medicine, University of Gothenburg, and Sahlgrenska University Hospital, Gothenburg, Sweden., Adiels M; Department of Molecular and Clinical Medicine, University of Gothenburg, and Sahlgrenska University Hospital, Gothenburg, Sweden., Hakkarainen A; Department of Radiology, HUS Medical Imaging Center, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland., Lundbom N; Department of Radiology, HUS Medical Imaging Center, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland., Kilicarslan M; Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Hallström BM; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden., Lundbom J; Department of Radiology, HUS Medical Imaging Center, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland., Vergès B; Department of Endocrinology-Diabetology, University Hospital and INSERM CRI 866, Dijon, France., Barrett PH; Faculty of Engineering, Computing and Mathematics, University of Western Australia, Perth, WA, Australia., Watts GF; Metabolic Research Centre, Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia., Serlie MJ; Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Nielsen J; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden.; Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden., Uhlén M; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden., Smith U; Department of Molecular and Clinical Medicine, University of Gothenburg, and Sahlgrenska University Hospital, Gothenburg, Sweden., Marschall HU; Department of Molecular and Clinical Medicine, University of Gothenburg, and Sahlgrenska University Hospital, Gothenburg, Sweden., Taskinen MR; Research programs Unit, Diabetes and Obesity, Helsinki University Hospital, University of Helsinki, Helsinki, Finland., Boren J; Department of Molecular and Clinical Medicine, University of Gothenburg, and Sahlgrenska University Hospital, Gothenburg, Sweden adilm@scilifelab.se jan.boren@wlab.gu.se.

Publikováno v: Molecular systems biology [Mol Syst Biol] 2017 Mar 02; Vol. 13 (3), pp. 916. Date of Electronic Publication: 2017 Mar 02.