Bumped kinase inhibitor 1369 is effective against Cystoisospora suis in vivo and in vitro

Autor: Shrestha, Aruna, Ojo, Kayode K., Koston, Florian, Ruttkowski, Bärbel, Vidadala, Rama S.R., Dorr, Carlie S., Navaluna, Edelmar D., Whitman, Grant R., Barrett, Kayleigh F., Barrett, Lynn K., Hulverson, Matthew A., Choi, Ryan, Michaels, Samantha A., Maly, Dustin J., Hemphill, Andrew, Van Voorhis, Wesley C., Joachim, Anja

Publikováno v: In International Journal for Parasitology: Drugs and Drug Resistance August 2019 10:9-19

Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba.

Autor: Tillery, Logan^1,2 (AUTHOR), Barrett, Kayleigh^1,2 (AUTHOR), Goldstein, Jenna³ (AUTHOR), Lassner, Jared W.³ (AUTHOR), Osterhout, Bram³ (AUTHOR), Tran, Nathan L.³ (AUTHOR), Xu, Lily³ (AUTHOR), Young, Ryan M.³ (AUTHOR), Craig, Justin^1,2 (AUTHOR), Chun, Ian^1,2 (AUTHOR), Dranow, David M.^2,4 (AUTHOR), Abendroth, Jan^2,4 (AUTHOR), Delker, Silvia L.^2,4 (AUTHOR), Davies, Douglas R.^2,4 (AUTHOR), Mayclin, Stephen J.^2,4 (AUTHOR), Calhoun, Brandy^2,4 (AUTHOR), Bolejack, Madison J.^2,4 (AUTHOR), Staker, Bart^2,5 (AUTHOR), Subramanian, Sandhya^2,5 (AUTHOR), Phan, Isabelle^2,5 (AUTHOR)

Publikováno v: PLoS ONE. 3/24/2021, Vol. 16 Issue 3, p1-19. 19p.

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Bumped kinase inhibitor 1369 is effective against Cystoisospora suis in vivo and in vitro

Autor: Shrestha, Aruna, Ojo, Kayode K, Koston, Florian, Ruttkowski, Bärbel, Vidadala, Rama S R, Dorr, Carlie S, Navaluna, Edelmar D, Whitman, Grant R, Barrett, Kayleigh F, Barrett, Lynn K, Hulverson, Matthew A, Choi, Ryan, Michaels, Samantha A, Maly, Dustin J, Hemphill, Andrew, Van Voorhis, Wesley C, Joachim, Anja

Cystoisosporosis is a leading diarrheal disease in suckling piglets. With the confirmation of resistance against the only available drug toltrazuril, there is a substantial need for novel therapeutics to combat the infection and its negative effects

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