Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Barret Kalindjian"'
Autor:
Maria B. Goncalves, Yue Wu, Earl Clarke, John Grist, Julien Moehlin, Marco Antonio Mendoza-Parra, Carl Hobbs, Barret Kalindjian, Henry Fok, Adrian P. Mander, Hana Hassanin, Daryl Bendel, Jörg Täubel, Tim Mant, Thomas Carlstedt, Julian Jack, Jonathan P. T. Corcoran
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Retinoic acid receptor β2 (RARβ2) is an emerging therapeutic target for spinal cord injuries (SCIs) with a unique multimodal regenerative effect. We have developed a first-in-class RARβ agonist drug, C286, that modulates neuron-glial pathways to i
Externí odkaz:
https://doaj.org/article/fc6f78e235584c4a814b98223f1ff1d8
Autor:
Goncalves, Maria B., Clarke, Earl, Jarvis, Christopher I., Barret Kalindjian, S., Pitcher, Thomas, Grist, John, Hobbs, Carl, Carlstedt, Thomas, Jack, Julian, Brown, Jane T., Mills, Mark, Mumford, Peter, Borthwick, Alan D., Corcoran, Jonathan P.T.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 April 2019 29(8):995-1000
Autor:
Carl Hobbs, S. Barret Kalindjian, John Grist, Thomas Carlstedt, Jonathan Corcoran, Maria B. Goncalves, Peter Mumford, Christopher I. Jarvis, Earl Clarke, Mark Trevor Mills, Jane Theresa Brown, Alan D. Borthwick, Julian Jack, Thomas Pitcher
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Oxadiazole replacement of an amide linkage in an RARα agonist template 1, followed by lead optimisation, has produced a highly potent and selective RARβ agonist 4-(5-(4,7-dimethylbenzofuran-2-yl)-1,2,4-oxadiazol-3-yl)benzoic acid (10) with good ora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cac033e762913965dd8ab36d045c10c
https://doi.org/10.1016/j.bmcl.2019.05.058
https://doi.org/10.1016/j.bmcl.2019.05.058
Autor:
Earl, Clarke, Christopher I, Jarvis, Maria B, Goncalves, S Barret, Kalindjian, David R, Adams, Jane T, Brown, Jason J, Shiers, David M A, Taddei, Elodie, Ravier, Stephanie, Barlow, Iain, Miller, Vanessa, Smith, Alan D, Borthwick, Jonathan P T, Corcoran
Publikováno v:
Bioorganic & Medicinal Chemistry
Graphical abstract
A ligand-based virtual screening exercise examining likely bioactive conformations of AM 580 (2) and AGN 193836 (3) was used to identify the novel, less lipophilic RARα agonist 4-(3,5-dichloro-4-ethoxybenzamido)benzoic acid 5
A ligand-based virtual screening exercise examining likely bioactive conformations of AM 580 (2) and AGN 193836 (3) was used to identify the novel, less lipophilic RARα agonist 4-(3,5-dichloro-4-ethoxybenzamido)benzoic acid 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a651db96aeac6253440f0f177d2dd404
https://pubmed.ncbi.nlm.nih.gov/29288071
https://pubmed.ncbi.nlm.nih.gov/29288071
Autor:
Wei Xun, Elliot Lilley, James W. Black, Gillian F. Watt, Paul Wright, Elaine Anne Harper, David A. Sykes, Sonia P. Roberts, Laurence Wright, David John Dunstone, Ildiko Maria Buck, Martin Keith Walker, S. Barret Kalindjian, Ian D. Linney, Iain Mair Mcdonald, Mark E. Shaxted, Eric P. Griffin, John Spencer, Robert Antony David Hull, Michael John Pether, Katherine Isobel Mary Steel
Publikováno v:
Journal of Medicinal Chemistry. 50:3101-3112
Starting from a novel, achiral 1,3,4-benzotriazepine-based CCK2 receptor antagonist, a process of optimization has afforded further compounds of this type that maintain the nanomolar affinity for recombinant, human CCK2 receptors and high selectivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619cdd94884144d4bc6c86d7bcb65d91
https://doi.org/10.1021/jm070139l
https://doi.org/10.1021/jm070139l
Autor:
Ian A. O'Neil, David J. Tapolczay, S. Barret Kalindjian, Alan P. Chorlton, V. Elena Ramos, Gemma L. Ellis
Publikováno v:
Tetrahedron Letters. 48:1687-1690
Functionalised hydroxylamine derivatives of (S)-proline and pipecolic acid have been prepared using a Cope elimination. These hydroxylamines have been found to undergo oxidation to the nitrone either in the presence of air or a catalytic quantity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26ffa0d26bb76797affcb25b404adafe
https://doi.org/10.1016/j.tetlet.2007.01.046
https://doi.org/10.1016/j.tetlet.2007.01.046
Autor:
Tracey Cooke, I. M. Buck, Laurence Wright, Atul Kotecha, S. Barret Kalindjian, Nigel P Shankley, Julia R Cushnir, Michael John Pether, C. M. R. Low, J G Vinter
Publikováno v:
Journal of Medicinal Chemistry. 48:6790-6802
A new molecular modeling approach has been used to derive a pharmacophore of the potent and selective cholecystokinin-2 (CCK(2)) receptor antagonist 5 (JB93182), based on features shared with two related series. The technique uses "field points" as s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca221ec3a8bee36a3417911787fffbe
https://doi.org/10.1021/jm049069y
https://doi.org/10.1021/jm049069y
Autor:
Rit Mermans, and Ildiko M. Buck, I. M. Mcdonald, Guy Winderickx, Bert Willemsens, Jaak Langens, Dominic Ormerod, S. Barret Kalindjian
Publikováno v:
Organic Process Research & Development. 9:499-507
A practical and scalable synthesis was developed that was used to prepare multikilogram batches of gastrazole, a selective cholecystokinin-2 receptor antagonist. In addition, evidence was found to indicate an amide bond-forming reaction proceeded via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a248312b2f2e4c7eb563d4376666f645
https://doi.org/10.1021/op0500638
https://doi.org/10.1021/op0500638
Autor:
Matthew Rudd, Paul Wright, Matthew J. Tozer, Jonathan W. Steed, S. Barret Kalindjian, Susan E. Gibson, Jerome O. Jones, Nello Mainolfi, Jamie D. Knight
Publikováno v:
Tetrahedron. 60:6945-6958
[7.7], [8.8], [9.9] and [13.13] Paracyclophanes and [9.9] and [13.13] metacyclophanes containing two unsaturated amino acid residues have been synthesised. An X-ray crystallographic study of three of the paracyclophanes and molecular modelling of two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6b063488ba8531c13f6457fc0d72cec
https://doi.org/10.1016/j.tet.2004.05.062
https://doi.org/10.1016/j.tet.2004.05.062
Publikováno v:
Synlett. 1:75-78
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e446418f163950cb121186dcad3b45eb
https://doi.org/10.1055/s-1997-693
https://doi.org/10.1055/s-1997-693