Effect of amoxicillin dose and treatment duration on the need for antibiotic re-treatment in children with community-acquired pneumonia: The CAP-IT randomized clinical trial

Autor: Bielicki, Julia A., Stöhr, Wolfgang, Barratt, Sam, Dunn, David, Naufal, Nishdha, Roland, Damian, Sturgeon, Kate, Finn, Adam, Rodriguez Ruiz, Juan Pablo, Malhotra, Surbhi, Powell, Colin, Faust, Saul N., Alcock, Anastasia E., Hall, Dani, Robinson, Gisela, Hawcutt, Daniel B., Lyttle, Mark D., Gibb, Diana M., Sharland, Mike, Molyneux, Elizabeth, Butler, Chris C., Smyth, Alan, Prichard, Catherine, Peto, Tim E.A., Cousens, Simon, Logan, Stuart, Bamford, Alasdair, Turkova, Anna, Goodman, Anna L., Fitzgerald, Felicity, Little, Paul S., Robotham, Julie, Wan, Mandy, Klein, Nigel, Rogers, Louise, Vitale, Elia, Rotheram, Matthew, Wright, Rachel, Lee, Elizabeth, Ohia, Udeme, Hartshorn, Stuart, Jyothish, Deepthi, Hopkins, Juliet, Ross, James G., Patel, Poonam, Fletcher, Hannah, Nundlall, Kribashnie, Carungcong, Jamie, Bull, Rhian, Burney, Nabila, Correia Da Costa, Patricia, Vergnano, Stefania, Walton, Beth, Smith, Alice, Ross, Michelle, Aplin, Lucie, Sheedy, Sarah, Kaur, Gurnie, Morgan, Jeff, Muller, Jennifer, Marshall, Gail, Nyamugunduru, Godfrey, Furness, John C., Eggington, Dawn, Holt, Susannah J., Gibbs, John, Burchett, Caroline, Lonsdale, Caroline, De-Beger, Sarah, Cheung, Ronny, Sheedy, Alyce B., Ahmad, Mohammad, Stockwell, Zoe, Giwa, Sarah, Murad, Arshid, Jerman, Katherine, Green, Joanna, Bird, Chris, Baron, Tanya K. Z., Segal, Shelley, Beer, Sally, Garcia Garcia, Maria Jose, Georgiou, Dom, Beadon, Kirsten, Martinez, Jose, Cantle, Fleur, Eastman, Hannah, Riozzi, Paul, Cotton, Hannah, Mullen, Niall, McCrone, Rhona, Corrigan, Paul, Salt, Gemma, Fairlie, Louise, Smith, Andrew, Starkey, Lizzie, Hayman, Mel, O'Riordan, Sean, Downes, Alice, Allen, Majorie, Turner, Louise, Ellis, Donna, Bandi, Srini, Patel, Rekha, Gough, Chris, McAulay, Megan, Conner, Louise, Gardner, Sharryn, Haslam, Zena, Morrison, Moira, Barrett, Michael J., Niermeyer, Madeleine, Barry, Ellen, Walton, Emily K., Kapur, Akshat, Richmond, Vivien, Foster, Steven J., Bland, R.M., Neil, Ashleigh, Milligan, Barry, Bannister, Helen, Bloom, Ben, Parikh, Ami, Skene, Imogen, Power, Helen, Boulton, Olivia, Astin-Chamberlain, Raine, Smith, David, Walters, Jonathon, Martin, Daniel, Noba, Lyrics, Potier, Katherine, Borland, Fiona, Wilson, Jill, Suleman, Zainab, Gilchrist, Judith, West, Noreen, Evans, Jayne, Morecombe, Juliet, Heath, Paul T., Iqbal, Yasser, Kohns Vasconcelos, Malte, Stefanova, Elena, Womack, Claire, Maconochie, Ian K., Laing, Suzanne, Jorgensen, Rikke, Nyirenda, Maggie, Keers, Sophie, Pilgrim, Samia, Gardiner, Emma, Cathie, Katrina, Bayreuther, Jane, Ensom, Ruth, Cornish, Emily K., Herrieven, Elizabeth-Jayne L., Townend, William, Sherris, Leanne, Williams, Paul

Publikováno v: JAMA : the journal of the American Medical Association
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
Bielicki, J A, Stöhr, W, Barratt, S, Dunn, D, Naufal, N, Roland, D, Sturgeon, K, Finn, A, Rodriguez-Ruiz, J P, Malhotra-Kumar, S, Powell, C, Faust, S N, Alcock, A E, Hall, D, Robinson, G, Hawcutt, D B, Lyttle, M D, Gibb, D M, Sharland, M 2021, ' Effect of Amoxicillin Dose and Treatment Duration on the Need for Antibiotic Re-treatment in Children With Community-Acquired Pneumonia : The CAP-IT Randomized Clinical Trial ', JAMA-Journal of the American Medical Association, vol. 326, no. 17, pp. 1713-1724 . https://doi.org/10.1001/jama.2021.17843

This randomized clinical trial compares the need for re-treatment of respiratory infection following hospitalization for community-acquired pneumonia among children receiving amoxicillin at high doses vs low doses and at 3-days vs 7-days duration. Qu

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https://eprints.soton.ac.uk/453839/

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Effect of Amoxicillin Dose and Treatment Duration on the Need for Antibiotic Re-treatment in Children With Community-Acquired Pneumonia: The CAP-IT Randomized Clinical Trial.

Autor: Bielicki JA; Pediatric Infectious Diseases Research Group, Medical Research Council Clinical Trial Unit at University College London, Institute for Infection and Immunity, St George's University of London, London, United Kingdom., Stöhr W; Medical Research Council Clinical Trials Unit at University College London, London, United Kingdom., Barratt S; Medical Research Council Clinical Trials Unit at University College London, London, United Kingdom., Dunn D; Medical Research Council Clinical Trials Unit at University College London, London, United Kingdom., Naufal N; Medical Research Council Clinical Trials Unit at University College London, London, United Kingdom., Roland D; Pediatric Emergency Medicine Leicester Academic (PEMLA) Group, Emergency Department, Leicester, United Kingdom.; SAPPHIRE Group, University of Leicester, Department of Health Sciences, Leicester, United Kingdom., Sturgeon K; Medical Research Council Clinical Trials Unit at University College London, London, United Kingdom., Finn A; Bristol Children's Vaccine Centre, Schools of Population Sciences and Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom., Rodriguez-Ruiz JP; Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium., Malhotra-Kumar S; Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium., Powell C; Emergency Medicine, Sidra Medical and Research Center, Doha, Qatar.; Division of Population Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom., Faust SN; National Institute for Health Research Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, United Kingdom., Alcock AE; Pediatric Emergency Medicine, Evelina Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom., Hall D; Pediatric Emergency Medicine, Evelina Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.; Pediatric Emergency Medicine, Children's Health Ireland at Crumlin, Ireland., Robinson G; Pediatric Emergency Medicine, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, United Kingdom., Hawcutt DB; Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.; Pediatric Medicines Research Unit, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom., Lyttle MD; Emergency Department, Bristol Royal Hospital for Children, Bristol, United Kingdom.; Faculty of Health and Applied Science, University of the West of England, Bristol, United Kingdom., Gibb DM; Medical Research Council Clinical Trials Unit at University College London, London, United Kingdom., Sharland M; Pediatric Infectious Diseases Research Group, Medical Research Council Clinical Trial Unit at University College London, Institute for Infection and Immunity, St George's University of London, London, United Kingdom.

Publikováno v: JAMA [JAMA] 2021 Nov 02; Vol. 326 (17), pp. 1713-1724.