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Investigating the Influence of Ribavirin on Human Respiratory Syncytial Virus RNA Synthesis by Using a High-Resolution Transcriptome Sequencing Approach

Autor: Aljabr, W, Touzelet, O, Pollakis, G, Wu, W, Munday, DC, Hughes, M, Hertz-Fowler, C, Kenny, J, Fearns, R, Barr, JN, Matthews, DA, Hiscox, JA

Publikováno v: Journal of Virology
Aljabr, W, Touzelet, O, Pollakis, G, Wu, W, Munday, D C, Hughes, M, Hertz-Fowler, C, Kenny, J, Fearns, R, Barr, J N, Matthews, D A & Hiscox, J A 2016, ' Investigating the Influence of Ribavirin on Human Respiratory Syncytial Virus RNA Synthesis by Using a High-Resolution Transcriptome Sequencing Approach ', Journal of Virology, vol. 90, no. 10, pp. 4876-4888 . https://doi.org/10.1128/JVI.02349-15
JOURNAL OF VIROLOGY

UNLABELLED: Human respiratory syncytial virus (HRSV) is a major cause of serious respiratory tract infection. Treatment options include administration of ribavirin, a purine analog, although the mechanism of its anti-HRSV activity is unknown. We used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f4cd94418815230843ddd0590fb97527
http://europepmc.org/articles/PMC4859727

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The Structure of the Human Respiratory Syncytial Virus M2-1 Protein Bound to the Interaction Domain of the Phosphoprotein P Defines the Orientation of the Complex

Autor: Selvaraj, M, Yegambaram, K, Todd, EJAA, Richard, CA, Dods, RL, Pangratiou, GM, Trinh, CH, Moul, SL, Murphy, JC, Mankouri, J, Eleouet, J-F, Barr, JN, Edwards, T

Publikováno v: mBio
mBio, Vol 9, Iss 6 (2018)
mBio 6 (9), . (2018)
mBio, American Society for Microbiology, 2018, 9 (6), ⟨10.1128/mBio.01554-18⟩
mBio, Vol 9, Iss 6, p e01554-18 (2018)

Human respiratory syncytial virus (HRSV) is a leading cause of respiratory illness, particularly in the young, elderly, and immunocompromised, and has also been linked to the development of asthma. HRSV replication depends on P and L, whereas transcr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::67d511f78c49407767de686db4484aff
https://pubmed.ncbi.nlm.nih.gov/31064823

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Identification of a small molecule inhibitor of Ebolavirus genome replication and transcription using in silico screening

Autor: Easton, V, McPhillie, M, Garcia-Dorival, I, Barr, JN, Edwards, TA, Foster, R, Fishwick, C, Harris, M

Ebola virus (EBOV) causes a severe haemorrhagic fever in humans and has a mortality rate over 50%. With no licensed drug treatments available, EBOV poses a significant threat. Investigations into possible therapeutics have been severely hampered by t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::b44b5f79abec1dcb66ff0e389c45c9ff
https://eprints.whiterose.ac.uk/132032/7/1-s2.0-S0166354218300706-main.pdf

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Elucidation of the Cellular Interactome of Ebola Virus Nucleoprotein and Identification of Therapeutic Targets

Autor: García-Dorival, I, Wu, W, Armstrong, SD, Barr, JN, Carroll, MW, Hewson, R, Hiscox, JA

Ebola virus (EBOV) infection results in severe disease and in some cases lethal haemorrhagic fever. The infection is directed by seven viral genes that encode nine viral proteins. By definition viruses are obligate intracellular parasites and require

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::0cb0e9278ae348c3a55970995113f826

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Heat Shock Protein 70 Family Members Interact with Crimean-Congo Hemorrhagic Fever Virus and Hazara Virus Nucleocapsid Proteins and Perform a Functional Role in the Nairovirus Replication Cycle

Autor: Surtees, R, Dowall, SD, Shaw, A, Armstrong, S, Hewson, R, Carroll, MW, Mankouri, J, Edwards, TA, Hiscox, JA, Barr, JN

Publikováno v: JOURNAL OF VIROLOGY

The Nairovirus genus of the Bunyaviridae family contains serious human and animal pathogens classified within multiple serogroups and species. Of these serogroups, the Crimean-Congo hemorrhagic fever virus (CCHFV) serogroup comprises sole members CCH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f98fe336d55845a585b2ea0d2edbcfd8

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Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation

Autor: Tanner, SJ, Ariza, A, Richard, CA, Kyle, HF, Dods, RL, Blondot, ML, Wu, W, Trincão, J, Trinh, CH, Hiscox, JA, Carroll, MW, Silman, NJ, Eléouët, JF, Edwards, TA, Barr, JN

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2014, 111 (4), pp.1580-1585. ⟨10.1073/pnas.1317262111⟩

International audience; The M2-1 protein of the important pathogen human respiratory syncytial virus is a zinc-binding transcription antiterminator that is essential for viral gene expression. We present the crystal structure of full-length M2-1 prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0aaa88bf7896b4d794b58214639cf432
https://hal.inrae.fr/hal-02631183

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