Fecal Microbiota Transplantation for Immune Checkpoint Inhibitor-Induced Colitis Is Safe and Contributes to Recovery: Two Case Reports.

Autor: Groenewegen B; Department of Medical Microbiology, Leiden University Medical Center, Albinusdreef 2, 2333ZA Leiden, The Netherlands., Terveer EM; Department of Medical Microbiology, Leiden University Medical Center, Albinusdreef 2, 2333ZA Leiden, The Netherlands., Joosse A; Department of Oncology, Erasmus Medical Center, Doctor Molewaterplein 40, 3015GD Rotterdam, The Netherlands., Barnhoorn MC; Department of Gastroenterology and Hepatology, Haga Hospital, Els Borst-Eilersplein 275, 2545AA The Hague, The Netherlands.; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Albinusdreef 2, 2333ZA Leiden, The Netherlands., Zwittink RD; Department of Medical Microbiology, Leiden University Medical Center, Albinusdreef 2, 2333ZA Leiden, The Netherlands.

Publikováno v: Journal of immunotherapy (Hagerstown, Md. : 1997) [J Immunother] 2023 Jul-Aug 01; Vol. 46 (6), pp. 216-220. Date of Electronic Publication: 2023 May 23.

Crohn's Disease-Associated and Cryptoglandular Fistulas: Differences and Similarities.

Autor: Zhou Z; Department of Gastroenterology and Hepatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Ouboter LF; Department of Gastroenterology and Hepatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.; Department of Immunology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Peeters KCMJ; Department of Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Hawinkels LJAC; Department of Gastroenterology and Hepatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Holman F; Department of Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Pascutti MF; Department of Immunology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Barnhoorn MC; Department of Gastroenterology and Hepatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., van der Meulen-de Jong AE; Department of Gastroenterology and Hepatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

Publikováno v: Journal of clinical medicine [J Clin Med] 2023 Jan 06; Vol. 12 (2). Date of Electronic Publication: 2023 Jan 06.

Cytokine Mixtures Mimicking the Local Milieu in Patients with Inflammatory Bowel Disease Impact Phenotype and Function of Mesenchymal Stromal Cells.

Autor: Barnhoorn MC; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., van der Meulen-de Jong AE; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Schrama ECLM; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands., Plug LG; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Verspaget HW; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Fibbe WE; Department of Internal Medicine and Nephrology, Leiden University Medical Center, Leiden, The Netherlands., van Pel M; Department of Internal Medicine and Nephrology, Leiden University Medical Center, Leiden, The Netherlands., Hawinkels LJAC; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Schepers K; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands.

Publikováno v: Stem cells translational medicine [Stem Cells Transl Med] 2022 Sep 21; Vol. 11 (9), pp. 932-945.

Contribution of CD3+CD8- and CD3+CD8+ T Cells to TNF-α Overexpression in Crohn Disease-Associated Perianal Fistulas and Induction of Epithelial-Mesenchymal Transition in HT-29 Cells.

Autor: Bruckner RS; Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Spalinger MR; Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Barnhoorn MC; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Feakins R; Department of Histopathology, Royal Free Hospital, London, United Kingdom., Fuerst A; Department of Surgery, Caritas-Krankenhaus St. Josef, Regensburg, Germany., Jehle EC; Department of Surgery, Oberschwaben-Klinik, Ravensburg, Germany., Rickenbacher A; Department of Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Turina M; Department of Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Niechcial A; Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Lang S; Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Hawinkels LJAC; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., van der Meulen-de Jong AE; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Verspaget HW; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Rogler G; Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland., Scharl M; Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.

Publikováno v: Inflammatory bowel diseases [Inflamm Bowel Dis] 2021 Mar 15; Vol. 27 (4), pp. 538-549.

Targeting Endoglin-Expressing Regulatory T Cells in the Tumor Microenvironment Enhances the Effect of PD1 Checkpoint Inhibitor Immunotherapy.

Autor: Schoonderwoerd MJA; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands., Koops MFM; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands., Angela RA; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands., Koolmoes B; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands., Toitou M; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands., Paauwe M; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands., Barnhoorn MC; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands., Liu Y; Department of Medicine, Duke University Medical Center, Durham, North Carolina., Sier CFM; Department of Surgery, Leiden University Medical Center, Leiden, the Netherlands., Hardwick JCH; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands., Nixon AB; Department of Medicine, Duke University Medical Center, Durham, North Carolina., Theuer CP; Tracon Pharmaceuticals, San Diego, California., Fransen MF; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands., Hawinkels LJAC; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands. L.J.A.C.Hawinkels@lumc.nl.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2020 Jul 15; Vol. 26 (14), pp. 3831-3842. Date of Electronic Publication: 2020 Apr 24.