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Therapeutic targeting of membrane-associated GRP78 in leukemia and lymphoma: preclinical efficacy in vitro and formal toxicity study of BMTP-78 in rodents and primates.

Autor: Staquicini DI; University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA.; Department of Internal Medicine, Division of Molecular Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA., D'Angelo S; University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA.; Department of Internal Medicine, Division of Molecular Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA., Ferrara F; University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA.; Department of Internal Medicine, Division of Molecular Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA., Karjalainen K; Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA., Sharma G; University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA., Smith TL; University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA.; Department of Internal Medicine, Division of Molecular Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA., Tarleton CA; University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA.; Department of Internal Medicine, Division of Molecular Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA., Jaalouk DE; Department of Biology, American University of Beirut, Beirut, Lebanon., Kuniyasu A; Department of Molecular Cell Pharmacology, Sojo University, Kumamoto, Japan., Baze WB; Department of Veterinary Science and Keeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer Center, Bastrop, TX, USA., Chaffee BK; Department of Veterinary Science and Keeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer Center, Bastrop, TX, USA., Hanley PW; Department of Veterinary Science and Keeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer Center, Bastrop, TX, USA., Barnhart KF; Department of Veterinary Science and Keeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer Center, Bastrop, TX, USA.; David H Koch Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Koivunen E; Department of Biological and Environmental Science, The University of Helsinki, Helsinki, Finland.; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Marchiò S; University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA.; Department of Internal Medicine, Division of Molecular Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.; Department of Oncology, University of Turin, Candiolo, Italy.; Candiolo Cancer Center-FPO, IRCCS, Candiolo, Italy., Sidman RL; Department of Neurology, Harvard Medical School, Boston, MA, USA., Cortes JE; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kantarjian HM; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Arap W; University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA.; Department of Internal Medicine, Division of Hematology/Oncology, University of New Mexico School of Medicine, Albuquerque, NM., Pasqualini R; University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA.; Department of Internal Medicine, Division of Molecular Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.

Publikováno v: The pharmacogenomics journal [Pharmacogenomics J] 2018 May 22; Vol. 18 (3), pp. 436-443. Date of Electronic Publication: 2017 Dec 05.