Codon-optimized RPGR improves stability and efficacy of AAV8 gene therapy in two mouse models of X-linked retinitis pigmentosa

Autor: Fischer, MD, McClements, ME, Martinez-Fernandez de la Camara, C, Bellingrath, J-S, Dauletbekov, D, Ramsden, SC, Hickey, DG, Barnard, AR, MacLaren, RE

Publikováno v: Fischer, M D, McClements, M E, Martinez-Fernandez de la Camara, C, Bellingrath, J S, Dauletbekov, D, Ramsden, S C, Hickey, D G, Barnard, A R & MacLaren, R E 2017, ' Codon-Optimized RPGR Improves Stability and Efficacy of AAV8 Gene Therapy in Two Mouse Models of X-Linked Retinitis Pigmentosa ', Molecular Therapy . https://doi.org/10.1016/j.ymthe.2017.05.005
Molecular Therapy

X-linked retinitis pigmentosa (XLRP) is generally a severe form of retinitis pigmentosa, a neurodegenerative, blinding disorder of the retina. 70% of XLRP cases are due to mutations in the retina-specific isoform of the gene encoding retinitis pigmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b99be5314253412b32744e4178e7b69d
https://doi.org/10.1016/j.ymthe.2017.05.005

AAV-Mediated Expression of Secreted Human Ciliary Neurotropic Factor (hCNTF) Leads to Long-Term Preservation of Cone Photoreceptors in an Autosomal Recessive Model of Retinitis Pigmentosa

Autor: Lipinski, DM, Barnard, AR, Singh, MS, Lee, E, MacLaren, RE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3d44366ed799164a9d0948ae2a1ce7da
https://ora.ox.ac.uk/objects/uuid:57a71b52-13f9-43df-9bfe-e66da14f953b

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Developmental Expression of the Cell Cycle Regulator p16 ^INK4a in Retinal Glial Cells: A Novel Marker for Immature Ocular Astrocytes?

Autor: Martinez-Fernandez de la Camara C; Nuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.; Oxford Eye Hospital, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, United Kingdom., Storm T; Nuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom., Salman A; Nuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom., Burgoyne T; Institute of Ophthalmology, University College London, London, United Kingdom.; Paediatric Respiratory Medicine, Primary Ciliary Dyskinesia Centre, Royal Brompton & Harefield NHS Trust, London, United Kingdom., Rasmussen MQ; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Orlans HO; Nuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom., Russell AJ; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom.; Department of Pharmacology, University of Oxford, Oxford, United Kingdom., Davies SG; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom., Barnard AR; Nuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.; Oxford Eye Hospital, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, United Kingdom., MacLaren RE; Nuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.; Oxford Eye Hospital, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, United Kingdom.

Publikováno v: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society [J Histochem Cytochem] 2023 Jun; Vol. 71 (6), pp. 301-320. Date of Electronic Publication: 2023 Jun 23.