Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Barnabas Szakal"'
Autor:
Barnabas Szakal, Dana Branzei
Publikováno v:
Molecular Oncology, Vol 17, Iss 10, Pp 1950-1952 (2023)
A new study by Longo, Roy et al. has solved the structure of the RAD51C‐XRCC3 (CX3) heterodimer with a bound ATP analog, identifying two main structural interfaces and defining separable replication fork stability roles. One function relates to the
Externí odkaz:
https://doaj.org/article/45b77f606e6c4d5ca2fa7bb853f4f6b0
Autor:
Sumedha Agashe, Chinnu Rose Joseph, Teresa Anne Clarisse Reyes, Demis Menolfi, Michele Giannattasio, Anja Waizenegger, Barnabas Szakal, Dana Branzei
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Smc5/6, part of the structural maintenance of chromosomes (SMC) family, plays roles in genome structural integrity. Here the authors reveal that Smc5/6 acts jointly with Top3 within the STR complex to mediate DNA replication completion at genomic nat
Externí odkaz:
https://doaj.org/article/05276fd617f0402ba03a03fa5c996f82
Autor:
Anja Waizenegger, Madhusoodanan Urulangodi, Carl P. Lehmann, Teresa Anne Clarisse Reyes, Irene Saugar, José Antonio Tercero, Barnabas Szakal, Dana Branzei
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Mus81-Mms4 endonuclease is critical for processing various DNA recombination structures. Here the authors uncover a regulatory mechanism of the endonuclease via posttranslational modifications involving SUMOylation and ubiquitylation that impact on g
Externí odkaz:
https://doaj.org/article/bd031adcb9114b46a9b98466291010e6
Autor:
Anjana Srivatsan, Bin-Zhong Li, Barnabas Szakal, Dana Branzei, Christopher D. Putnam, Richard D. Kolodner
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
SWR-C and its substrate the histone variant Htz1 are considered important for genome maintenance. Here the authors reveal that SWR-C/Htz1 plays a critical role during replication stress caused by absence of the replication fork progression proteins M
Externí odkaz:
https://doaj.org/article/26b3c91b973843c4a9d010d3be601fc1
Autor:
Jacob N. Bonner, Koyi Choi, Xiaoyu Xue, Nikko P. Torres, Barnabas Szakal, Lei Wei, Bingbing Wan, Meret Arter, Joao Matos, Patrick Sung, Grant W. Brown, Dana Branzei, Xiaolan Zhao
Publikováno v:
Cell Reports, Vol 16, Iss 2, Pp 368-378 (2016)
Timely removal of DNA recombination intermediates is critical for genome stability. The DNA helicase-topoisomerase complex, Sgs1-Top3-Rmi1 (STR), is the major pathway for processing these intermediates to generate conservative products. However, the
Externí odkaz:
https://doaj.org/article/603817206fe94d348474bc7447aa4ea4
Publikováno v:
PLoS Genetics, Vol 6, Iss 11, p e1001205 (2010)
Damage tolerance mechanisms mediating damage-bypass and gap-filling are crucial for genome integrity. A major damage tolerance pathway involves recombination and is referred to as template switch. Template switch intermediates were visualized by 2D g
Externí odkaz:
https://doaj.org/article/641967dd5086490c852f392f3782c8d2
Autor:
Tamara L. Hendrickson, J. Christopher Fromme, Sudeep Banjade, Kaixian Liu, Daniel J. Barrero, Jing Zhang, Aditya Krishnakumar, Zhi Zheng, Saket R. Bagde, Travis J. Ness, Caroline Kisker, Xiao-Han Li, Scott Keeney, Viktoriya G. Stancheva, Eric C. Greene, Dana Branzei, Sergey Ovchinnikov, David Baker, Jochen Kuper, Elizabeth A. Miller, Upasana Roy, Barnabas Szakal, Josep Rizo, Israel S. Fernández, Ivan Anishchenko, Ian R. Humphreys, Minkyung Baek, Sue Biggins, Jimin Pei, Qian Cong
Publikováno v:
Science
Protein-protein interactions play critical roles in biology, but the structures of many eukaryotic protein complexes are unknown, and there are likely many interactions not yet identified. We take advantage of advances in proteome-wide amino acid coe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a37aed18d09e7e5517aeadb3ec6ac6
https://europepmc.org/articles/PMC7612107/
https://europepmc.org/articles/PMC7612107/
Autor:
Barnabas Szakal, Dana Branzei
Publikováno v:
Current opinion in geneticsdevelopment. 71
Helicases are in the spotlight of DNA metabolism and are critical for DNA repair in all domains of life. At their biochemical core, they bind and hydrolyze ATP, converting this energy to translocate unidirectionally, with different strand polarities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495cb85f12221146d12dd8d42d123a3f
https://pubmed.ncbi.nlm.nih.gov/34271541
https://pubmed.ncbi.nlm.nih.gov/34271541
Autor:
Anja Waizenegger, Demis Menolfi, Sumedha Agashe, Teresa Anne Clarisse Reyes, Dana Branzei, Barnabas Szakal, Michele Giannattasio, Chinnu Rose Joseph
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Smc5/6 is essential for genome structural integrity by yet unknown mechanisms. Here we find that Smc5/6 co-localizes with the DNA crossed-strand processing complex Sgs1-Top3-Rmi1 (STR) at genomic regions known as natural pausing sites (NPSs) where it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d811f707ae4a54ff46c34db637b7ef3d
https://doi.org/10.1038/s41467-021-22217-w
https://doi.org/10.1038/s41467-021-22217-w
Autor:
Alberto Jiménez-Martín, Dana Branzei, Irene Saugar, Chinnu Rose Joseph, Barnabas Szakal, José Antonio Tercero, Alexandra Mayer, Carl P. Lehmann
Publikováno v:
Science Advances
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
DNA damage tolerance (DDT) is crucial for genome integrity maintenance. DDT is mainly carried out by template switch recombination, an error-free mode of overcoming DNA lesions, or translesion DNA synthesis, which is error-prone. Here, we investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc1a7c959a7312e4524a9572ecf0e1a
https://doi.org/10.1126/sciadv.aaz3327
https://doi.org/10.1126/sciadv.aaz3327