Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Barnabas Nyesiga"'
1
Akademický článek
RUBY® – a tetravalent (2+2) bispecific antibody format with excellent functionality and IgG-like stability, pharmacology and developability properties
Autor: Barnabas Nyesiga, Mattias Levin, Anna Säll, Anna Rosén, Kim Jansson, Sara Fritzell, Karin Hägerbrand, Dietmar Weilguny, Laura von Schantz
Publikováno v: mAbs, Vol 16, Iss 1 (2024)
ABSTRACTDespite the large number of existing bispecific antibody (bsAb) formats, the generation of novel bsAbs is still associated with development and bioprocessing challenges. Here, we present RUBY, a novel bispecific antibody format that allows ra
Externí odkaz: https://doaj.org/article/3554ed116f6c45079b118217d1d8fd6f
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2
Akademický článek
Bispecific antibodies targeting CD40 and tumor-associated antigens promote cross-priming of T cells resulting in an antitumor response superior to monospecific antibodies
Autor: Malin Lindstedt, Peter Ellmark, Lennart Greiff, Karin Hägerbrand, Laura von Schantz, Mia Thagesson, Doreen Werchau, Kristine Smedenfors, Anna Rosén, Anette Sundstedt, Adnan Deronic, Lill Ljung, Mattias Levin, Laura Varas, Anna Säll, Christina Sakellariou, Barnabas Nyesiga, David Gomez Jimenez, Mona Celander, Deniz Bölükbas, Fredrika Carlsson
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 11 (2022)
Background Indications with poor T-cell infiltration or deficiencies in T-cell priming and associated unresponsiveness to established immunotherapies represent an unmet medical need in oncology. CD40-targeting therapies designed to enhance antigen pr
Externí odkaz: https://doaj.org/article/3ded16f9cf504c5983b33e362b58d5fd
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4
Akademický článek
Clinical predictors and accuracy of empiric tuberculosis treatment among sputum smear-negative HIV-infected adult TB suspects in Uganda.
Autor: Lydia Nakiyingi, John Mark Bwanika, Bruce Kirenga, Damalie Nakanjako, Catherine Katabira, Gloria Lubega, Joseph Sempa, Barnabas Nyesiga, Heidi Albert, Yukari C Manabe
Publikováno v: PLoS ONE, Vol 8, Iss 9, p e74023 (2013)
The existing diagnostic algorithms for sputum smear-negative tuberculosis (TB) are complicated, time-consuming, and often difficult to implement. The decision to initiate TB treatment in resource-limited countries is often largely based on clinical p
Externí odkaz: https://doaj.org/article/4e4bce8593494278ac8133a4c59e2339
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5
Akademický článek
Operational implementation of LED fluorescence microscopy in screening tuberculosis suspects in an urban HIV clinic in Uganda.
Autor: Heidi Albert, Lydia Nakiyingi, Joseph Sempa, Olive Mbabazi, Sheena Mukkada, Barnabas Nyesiga, Mark D Perkins, Yukari C Manabe
Publikováno v: PLoS ONE, Vol 8, Iss 9, p e72556 (2013)
BACKGROUND: Light emitting diode (LED) fluorescence microscopy (FM) is an affordable, technology targeted for use in resource-limited settings and recommended for widespread roll-out by the World Health Organization (WHO). We sought to compare the op
Externí odkaz: https://doaj.org/article/55cda1d4b2534944a6a5dc09b60609c4
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6
Akademický článek
Performance of three LED-based fluorescence microscopy systems for detection of tuberculosis in Uganda.
Autor: Heidi Albert, Yukari Manabe, George Lukyamuzi, Patrick Ademun, Sheena Mukkada, Barnabas Nyesiga, Moses Joloba, C N Paramasivan, Mark D Perkins
Publikováno v: PLoS ONE, Vol 5, Iss 12, p e15206 (2010)
BACKGROUND: Direct smear microscopy using Ziehl-Neelsen (ZN) staining is the mainstay of tuberculosis (TB) diagnosis in most high burden countries, but is limited by low sensitivity in routine practice, particularly in high human immunodeficiency vir
Externí odkaz: https://doaj.org/article/6f29498525044b409098d430af29565b
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7
751 Neo-X-Prime bispecific antibodies targeting CD40 and tumor antigens promote cross-presentation of tumor exosome-derived neoantigen and induce superior anti-tumor responses compared to CD40 mAb
Autor: Barnabas Nyesiga, Mia Thagesson, Anna Rosén, Karin Hägerbrand, Mattias Levin, Karin Barchan, Laura Varas, Anette Sundstedt, Anna Säll, Doreen Werchau, Peter Ellmark, Lill Ljung, Laura Von Schantz, Eva Lindqvist, Adnan Deronic
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundAlligator's Neo-X-Prime platform aims to enable antigen presenting cells to efficiently enhance priming of tumor neoantigen-specific T cells with the goal of overcoming PD-1 resistance in certain tumor types. We hypothesize that binding of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254b3a98cca7dddc470b999478d652d6
https://doaj.org/article/9e6a3658910c424b887736939f0b115c
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10
CD81 (Cluster of Differentiation 81)
Autor: Anette Gjörloff-Wingren, Sylwia Hasterok, Barnabas Nyesiga
Publikováno v: Atlas of Genetics and Cytogenetics in Oncology and Haematology.
Cluster of differentiation (CD81) is a type of protein, which is encoded by CD81 gene. Beside that CD81 is also known under other names such as Target of the Antiproliferative Antibody 1 (TAPA-1) and Tetraspanin-28 (TSPAN28). Location of CD81 is know
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50aed8d998e181f33ceca61a1093994d
https://doi.org/10.4267/2042/70766
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