Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Barmak Modrek"'
Autor:
Guy Cavet, David Stokoe, John Chant, Levi A. Garraway, Paul Waring, Howard M. Stern, Somasekar Seshagiri, Zora Modrusan, Thinh Pham, William M. Lin, Steve Guerrero, Peng Yue, Sankar Mohan, Eva Lin, Ajay Pandita, Lin Ge, Barmak Modrek
Although activating mutations and gains in copy number are key mechanisms for oncogene activation, the relationship between the two is not well understood. In this study, we focused on KRAS copy gains and mutations in non–small cell lung cancer. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083ea643665429b21da4bc48096c95c1
https://doi.org/10.1158/1541-7786.c.6542172
https://doi.org/10.1158/1541-7786.c.6542172
Autor:
Zora Modrusan, Barmak Modrek, David F. Choy, Grazyna Fedorowicz, John V. Fahy, Alexander R. Abbas, Joseph R. Arron, Hilary Clark, Sarah K. Kummerfeld, Prescott G. Woodruff, Lawren C. Wu
Publikováno v:
The Journal of Immunology. 186:1861-1869
Asthma is canonically thought of as a disorder of excessive Th2-driven inflammation in the airway, although recent studies have described heterogeneity with respect to asthma pathophysiology. We have previously described distinct phenotypes of asthma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206b91878540d7b67a39687c270b0bbc
https://doi.org/10.4049/jimmunol.1002568
https://doi.org/10.4049/jimmunol.1002568
Autor:
David F. Choy, Joseph R. Arron, John V. Fahy, Barmak Modrek, Alexander R. Abbas, Laura L. Koth, Guiquan Jia, Almut Ellwanger, Prescott G. Woodruff
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 180:388-395
T-helper type 2 (Th2) inflammation, mediated by IL-4, IL-5, and IL-13, is considered the central molecular mechanism underlying asthma, and Th2 cytokines are emerging therapeutic targets. However, clinical studies increasingly suggest that asthma is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2dd70f927f7e34219de5147c2b379c
https://doi.org/10.1164/rccm.200903-0392oc
https://doi.org/10.1164/rccm.200903-0392oc
Autor:
Zora Modrusan, David Stokoe, Lin Ge, William M. Lin, Levi A. Garraway, John Chant, Barmak Modrek, Eva Lin, Steve Guerrero, Ajay Pandita, Thinh Pham, Howard M. Stern, Somasekar Seshagiri, Paul Waring, Guy Cavet, Peng Yue, Sankar Mohan
Publikováno v:
Molecular Cancer Research. 7:1244-1252
Although activating mutations and gains in copy number are key mechanisms for oncogene activation, the relationship between the two is not well understood. In this study, we focused on KRAS copy gains and mutations in non–small cell lung cancer. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe07e28e7a577dad094d35c86edda7e
https://doi.org/10.1158/1541-7786.mcr-08-0532
https://doi.org/10.1158/1541-7786.mcr-08-0532
Autor:
Christopher Lee, Barmak Modrek
Publikováno v:
Nature Genetics. 34:177-180
One of the most interesting opportunities in comparative genomics is to compare not only genome sequences but additional phenomena, such as alternative splicing, using orthologous genes in different genomes to find similarities and differences betwee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac98a4564403f1a89dcd81c15a30065f
https://doi.org/10.1038/ng1159
https://doi.org/10.1038/ng1159
Publikováno v:
Nucleic Acids Research. 31:101-105
Recently, genomics analyses have demonstrated that alternative splicing is widespread in mammalian genomes (30-60% of genes reported to have multiple isoforms), and may be one of their most important mechanisms of functional regulation. However, by c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0665f12062213d00eca36c0fced45a2
https://doi.org/10.1093/nar/gkg029
https://doi.org/10.1093/nar/gkg029
Publikováno v:
Nucleic Acids Research. 30:3754-3766
We have developed an automated method for discovering tissue-specific regulation of alternative splicing through a genome-wide analysis of expressed sequence tags (ESTs). Using this approach, we have identified 667 tissue-specific alternative splice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c46cc4374ea6de1865cfe3c8b743eed
https://doi.org/10.1093/nar/gkf492
https://doi.org/10.1093/nar/gkf492
Autor:
Barmak Modrek, Christopher Lee
Publikováno v:
Nature Genetics. 30:13-19
Recent genome-wide analyses of alternative splicing indicate that 40-60% of human genes have alternative splice forms, suggesting that alternative splicing is one of the most significant components of the functional complexity of the human genome. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb21ea561a65cb4bb2127d2466f9e2e5
https://doi.org/10.1038/ng0102-13
https://doi.org/10.1038/ng0102-13
Autor:
Grazyna Fedorowicz, Hilary Clark, Sarah K. Kummerfeld, Barmak Modrek, Prescott G. Woodruff, Lawren C. Wu, Joseph R. Arron, Alexander R. Abbas, David F. Choy, John V. Fahy, Zora Modrusan
Publikováno v:
C21. MECHANISMS OF TH2 INFLAMMATION IN THE LUNG.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a76c2f9df195e641cb31a5d3a47b564
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4028
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4028
Publikováno v:
Journal of proteome research. 3(1)
We have constructed a database of alternatively spliced protein forms (ASP), consisting of 13,384 protein isoform sequences of 4422 human genes (www.bioinformatics.ucla.edu/ASP). We identified fifty protein domain types that were selectively removed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0edd3f45673016bf44c8048c1cd74c
https://pubmed.ncbi.nlm.nih.gov/14998157
https://pubmed.ncbi.nlm.nih.gov/14998157