PTPRZ1-Targeting RNA CAR T Cells Exert Antigen-Specific and Bystander Antitumor Activity in Glioblastoma.

Autor: Martinez Bedoya D; Brain Tumor and Immune Cell Engineering Laboratory, Agora Cancer Research Center, Lausanne, Switzerland.; Swiss Cancer Center Léman (SCCL), Lausanne, Switzerland.; Center for Translational Research in Onco-Hematology, University of Geneva, Geneva, Switzerland., Marinari E; Brain Tumor and Immune Cell Engineering Laboratory, Agora Cancer Research Center, Lausanne, Switzerland.; Swiss Cancer Center Léman (SCCL), Lausanne, Switzerland.; Center for Translational Research in Onco-Hematology, University of Geneva, Geneva, Switzerland., Davanture S; Brain Tumor and Immune Cell Engineering Laboratory, Agora Cancer Research Center, Lausanne, Switzerland.; Swiss Cancer Center Léman (SCCL), Lausanne, Switzerland.; Center for Translational Research in Onco-Hematology, University of Geneva, Geneva, Switzerland., Castillo Cantero L; Brain Tumor and Immune Cell Engineering Laboratory, Agora Cancer Research Center, Lausanne, Switzerland.; Swiss Cancer Center Léman (SCCL), Lausanne, Switzerland.; Center for Translational Research in Onco-Hematology, University of Geneva, Geneva, Switzerland., Erraiss S; Brain Tumor and Immune Cell Engineering Laboratory, Agora Cancer Research Center, Lausanne, Switzerland.; Swiss Cancer Center Léman (SCCL), Lausanne, Switzerland.; Center for Translational Research in Onco-Hematology, University of Geneva, Geneva, Switzerland., Dockerill M; Department of Organic Chemistry, NCCR Chemical Biology, Faculty of Science, University of Geneva, Geneva, Switzerland., Barluenga S; Department of Organic Chemistry, NCCR Chemical Biology, Faculty of Science, University of Geneva, Geneva, Switzerland., Winssinger N; Department of Organic Chemistry, NCCR Chemical Biology, Faculty of Science, University of Geneva, Geneva, Switzerland., Schaller K; Division of Neurosurgery, Department of Clinical Neurosciences, Geneva University Hospital, Geneva, Switzerland., Bijlenga P; Division of Neurosurgery, Department of Clinical Neurosciences, Geneva University Hospital, Geneva, Switzerland., Momjian S; Division of Neurosurgery, Department of Clinical Neurosciences, Geneva University Hospital, Geneva, Switzerland., Voize C; Department of Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.; Center of Experimental Therapeutics, Department of Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.; Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland., Tissot SR; Department of Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.; Center of Experimental Therapeutics, Department of Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.; Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland., Kandalaft LE; Department of Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.; Center of Experimental Therapeutics, Department of Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.; Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland., Hammel P; Geneva Antibody Facility, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Cosson P; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Walker PR; Brain Tumor and Immune Cell Engineering Laboratory, Agora Cancer Research Center, Lausanne, Switzerland.; Swiss Cancer Center Léman (SCCL), Lausanne, Switzerland.; Center for Translational Research in Onco-Hematology, University of Geneva, Geneva, Switzerland., Dutoit V; Brain Tumor and Immune Cell Engineering Laboratory, Agora Cancer Research Center, Lausanne, Switzerland.; Swiss Cancer Center Léman (SCCL), Lausanne, Switzerland.; Center for Translational Research in Onco-Hematology, University of Geneva, Geneva, Switzerland., Migliorini D; Brain Tumor and Immune Cell Engineering Laboratory, Agora Cancer Research Center, Lausanne, Switzerland.; Swiss Cancer Center Léman (SCCL), Lausanne, Switzerland.; Center for Translational Research in Onco-Hematology, University of Geneva, Geneva, Switzerland.; Department of Oncology, Geneva University Hospital, Geneva, Switzerland.

Publikováno v: Cancer immunology research [Cancer Immunol Res] 2024 Dec 03; Vol. 12 (12), pp. 1718-1735.

Duplex formation and secondary structure of {\gamma}-PNA observed by NMR and CD

Autor: Viéville, J. M. P., Barluenga, S., Winssinger, N., Delsuc, M-A.

Peptide Nucleic Acids (PNA) are non-natural oligonucleotides mimics. {\gamma}-PNA backbone are formed by standard nucleic acids nucleobases connected by a neutral N-(2-aminoethyl)glycine backbone linked by a peptide bond. In this study, we use Nuclea

Externí odkaz: http://arxiv.org/abs/1505.05616

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A mating mechanism to generate diversity for the Darwinian selection of DNA-encoded synthetic molecules.

Autor: Vummidi BR; Department of Organic Chemistry, NCCR Chemical Biology, Faculty of Science, University of Geneva, Geneva, Switzerland., Farrera-Soler L; Department of Organic Chemistry, NCCR Chemical Biology, Faculty of Science, University of Geneva, Geneva, Switzerland., Daguer JP; Department of Organic Chemistry, NCCR Chemical Biology, Faculty of Science, University of Geneva, Geneva, Switzerland., Dockerill M; Department of Organic Chemistry, NCCR Chemical Biology, Faculty of Science, University of Geneva, Geneva, Switzerland., Barluenga S; Department of Organic Chemistry, NCCR Chemical Biology, Faculty of Science, University of Geneva, Geneva, Switzerland., Winssinger N; Department of Organic Chemistry, NCCR Chemical Biology, Faculty of Science, University of Geneva, Geneva, Switzerland. Nicolas.Winssinger@unige.ch.

Publikováno v: Nature chemistry [Nat Chem] 2022 Feb; Vol. 14 (2), pp. 141-152. Date of Electronic Publication: 2021 Dec 06.

Withaferin A, a polyfunctional pharmacophore that includes covalent engagement of IPO5, is an inhibitor of influenza A replication.

Autor: Patouret R; Department of Organic Chemistry, Faculty of Science, NCCR Chemical Biology, University of Geneva, 1211 Geneva, Switzerland., Barluenga S; Department of Organic Chemistry, Faculty of Science, NCCR Chemical Biology, University of Geneva, 1211 Geneva, Switzerland., Winssinger N; Department of Organic Chemistry, Faculty of Science, NCCR Chemical Biology, University of Geneva, 1211 Geneva, Switzerland. Electronic address: nicolas.winssinger@unige.ch.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2022 Sep 01; Vol. 69, pp. 116883. Date of Electronic Publication: 2022 Jun 18.