The flagellin FliC of Clostridium difficile is responsible for pleiotropic gene regulation during in vivo infection.

Autor: Amira Barketi-Klai, Marc Monot, Sandra Hoys, Sylvie Lambert-Bordes, Sarah A Kuehne, Nigel Minton, Anne Collignon, Bruno Dupuy, Imad Kansau

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e96876 (2014)

Clostridium difficile is the main agent responsible for hospital acquired antibiotic associated diarrhoea. In recent years, epidemic strains have emerged causing more severe infections. Whilst C. difficile has two major virulence factors, toxins TcdA

Externí odkaz: https://doaj.org/article/aac4d9af67094a46939704320fb7a8c5

Deciphering Adaptation Strategies of the Epidemic Clostridium difficile 027 Strain during Infection through In Vivo Transcriptional Analysis.

Autor: Kansau, Imad¹, Barketi-Klai, Amira¹, Monot, Marc², Hoys, Sandra¹, Dupuy, Bruno², Janoir, Claire¹, Collignon, Anne¹ anne.collignon@u-psud.fr

Publikováno v: PLoS ONE. 6/28/2016, Vol. 11 Issue 6, p1-13. 13p.

Deciphering Adaptation Strategies of the Epidemic Clostridium difficile 027 Strain during Infection through In Vivo Transcriptional Analysis

Autor: Marc Monot, Imad Kansau, Sandra Hoys, Amira Barketi-Klai, Bruno Dupuy, Claire Janoir, Anne Collignon

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2016, 11 (6), pp.e0158204. ⟨10.1371/journal.pone.0158204⟩
PLoS ONE, Vol 11, Iss 6, p e0158204 (2016)
PLoS ONE, 2016, 11 (6), pp.e0158204. ⟨10.1371/journal.pone.0158204⟩

International audience; Clostridium difficile is responsible for a wide spectrum of infection from asymptomatic carriage to severe, relapsing colitis. Since 2003, C. difficile infections have increased with a higher morbidity and mortality due to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c1c9083211a113903e9badc50182c6
http://europepmc.org/articles/PMC4924792

The role of flagella in Clostridium difficile pathogenesis:comparison between a non-epidemic and an epidemicstrain

Autor: Baban, Soza T., Kuehne, Sarah A., Barketi-Klai, Amira, Cartman, Stephen T., Kelly, Michelle L., Hardie, Kim R., Kansau, Imad, Collignon, Anne, Minton, Nigel P.

Clostridium difficile is a major cause of healthcare-associated infection and inflicts a considerable financial burden on healthcare systems worldwide. Disease symptoms range from self-limiting diarrhoea to fatal pseudomembranous colitis. Whilst C. d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::c89b0d55bdd05d130cbbb40dc2dc6861
https://nottingham-repository.worktribe.com/file/717615/1/PMID-24086268.pdf

Surface-layer (S-layer) of human and animal Clostridium difficile strains and their behaviour in adherence to epithelial cells and intestinal colonization

Autor: Imad Kansau, Amira Barketi-Klai, Patrizia Spigaglia, Sandra Janezic, Paola Mastrantonio, Fabrizio Barbanti, Maja Rupnik, Anne Collignon

Publikováno v: Journal of Medical Microbiology
Journal of Medical Microbiology, Society for General Microbiology, 2013, 63, pp.1386-1393. ⟨10.1099/jmm.0.056556-0⟩

Clostridium difficile is a frequent cause of severe, recurrent post-antibiotic diarrhoea and pseudomembranous colitis. The surface layer (S-layer) is the predominant outer surface component of C. difficile which is involved in pathogen–host interac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb54860cf1235eef1327716df624eca
https://hal.inrae.fr/hal-02651482