Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques

Autor: King, Hannah A. D., Joyce, M. Gordon, Lakhal-Naouar, Ines, Ahmed, Aslaa, Cincotta, Camila Macedo, Subra, Caroline, Peachman, Kristina K., Hack, Holly R., Chen, Rita E., Thomas, Paul V., Chen, Wei-Hung, Sankhala, Rajeshwer S., Hajduczki, Agnes, Martinez, Elizabeth J., Peterson, Caroline E., Chang, William C., Choe, Misook, Smith, Clayton, Headley, Jarrett A., Elyard, Hanne A., Cook, Anthony, Anderson, Alexander, Wuertz, Kathryn McGuckin, Dong, Ming, Swafford, Isabella, Case, James B., Currier, Jeffrey R., Lal, Kerri G., Amare, Mihret F., Dussupt, Vincent, Molnar, Sebastian, Daye, Sharon P., Zeng, Xiankun, Barkei, Erica K., Alfson, Kendra, Staples, Hilary M., Carrion, Ricardo, Krebs, Shelly J., Paquin-Proulx, Dominic, Karasavvas, Nicos, Polonis, Victoria R., Jagodzinski, Linda L., Vasan, Sandhya, Scott, Paul T., Huang, Yaoxing, Nair, Manoj S., Ho, David D., de Val, Natalia, Diamond, Michael S., Lewisi, Mark G., Rao, Mangala, Matyas, Gary R., Gromowski, Gregory D., Peel, Sheila A., Michael, Nelson L., Modjarrad, Kayvon, Bolton, Diane L.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2021 Sep . 118(38), 1-11.

Externí odkaz: https://www.jstor.org/stable/27075662

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A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with B.1.1.7 and B.1.351 virus variants in Syrian golden hamsters.

Autor: Wuertz KM; U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA., Barkei EK; Veterinary Pathology Division, Walter Reed Army Institute of Research, Silver Spring, Maryland USA., Chen WH; Emerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA., Martinez EJ; Emerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA., Lakhal-Naouar I; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA.; Diagnostics Countermeasures Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA., Jagodzinski LL; Diagnostics Countermeasures Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA., Paquin-Proulx D; U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA., Gromowski GD; Virus Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA., Swafford I; U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA., Ganesh A; U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA.; Oak Ridge Institute of Science and Education, Oak Ridge, Tennessee USA., Dong M; U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA., Zeng X; Pathology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland USA., Thomas PV; Emerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA., Sankhala RS; Emerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA., Hajduczki A; Emerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA., Peterson CE; Emerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA., Kuklis C; Virus Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA., Soman S; Virus Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA., Wieczorek L; U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA., Zemil M; U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA., Anderson A; Emerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA.; Oak Ridge Institute of Science and Education, Oak Ridge, Tennessee USA., Darden J; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA.; Diagnostics Countermeasures Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA., Hernandez H; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA.; Diagnostics Countermeasures Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA., Grove H; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA.; Diagnostics Countermeasures Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA., Dussupt V; U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA., Hack H; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA.; Diagnostics Countermeasures Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA., de la Barrera R; Pilot Bioproduction Facility, Walter Reed Army Institute of Research, Silver Spring, Maryland USA., Zarling S; Pilot Bioproduction Facility, Walter Reed Army Institute of Research, Silver Spring, Maryland USA., Wood JF; Pilot Bioproduction Facility, Walter Reed Army Institute of Research, Silver Spring, Maryland USA., Froude JW; Pilot Bioproduction Facility, Walter Reed Army Institute of Research, Silver Spring, Maryland USA., Gagne M; Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland USA., Henry AR; Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland USA., Mokhtari EB; Virus Persistence and Dynamics Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland USA., Mudvari P; Virus Persistence and Dynamics Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland USA., Krebs SJ; U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA., Pekosz AS; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland USA., Currier JR; Virus Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA., Kar S; BioQual, Inc., Rockville, Maryland USA., Porto M; BioQual, Inc., Rockville, Maryland USA., Winn A; BioQual, Inc., Rockville, Maryland USA., Radzyminski K; BioQual, Inc., Rockville, Maryland USA., Lewis MG; BioQual, Inc., Rockville, Maryland USA., Vasan S; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA., Suthar M; Emory Vaccine Center, Department of Pediatrics, Emory School of Medicine, Atlanta, Georgia USA., Polonis VR; U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA., Matyas GR; U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA., Boritz EA; Virus Persistence and Dynamics Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland USA., Douek DC; Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland USA., Seder RA; Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland USA., Daye SP; One Health Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland USA., Rao M; U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA., Peel SA; Diagnostics Countermeasures Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA., Joyce MG; Emerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA.; These authors contributed equally., Bolton DL; U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA.; These authors contributed equally., Michael NL; Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA.; These authors contributed equally., Modjarrad K; Emerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA.; These authors contributed equally.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2021 Jun 16. Date of Electronic Publication: 2021 Jun 16.

Efficacy of a Broadly Neutralizing SARS-CoV-2 Ferritin Nanoparticle Vaccine in Nonhuman Primates.

Autor: Joyce MG, King HAD, Naouar IE, Ahmed A, Peachman KK, Cincotta CM, Subra C, Chen RE, Thomas PV, Chen WH, Sankhala RS, Hajduczki A, Martinez EJ, Peterson CE, Chang WC, Choe M, Smith C, Lee PJ, Headley JA, Taddese MG, Elyard HA, Cook A, Anderson A, McGuckin-Wuertz K, Dong M, Swafford I, Case JB, Currier JR, Lal KG, O'Connell RJ, Molnar S, Nair MS, Dussupt V, Daye SP, Zeng X, Barkei EK, Staples HM, Alfson K, Carrion R, Krebs SJ, Paquin-Proulx D, Karasavva N, Polonis VR, Jagodzinski LL, Amare MF, Vasan S, Scott PT, Huang Y, Ho DD, de Val N, Diamond MS, Lewis MG, Rao M, Matyas GR, Gromowski GD, Peel SA, Michael NL, Bolton DL, Modjarrad K

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2021 Mar 25. Date of Electronic Publication: 2021 Mar 25.