Ustekinumab induction and maintenance therapy in refractory Crohn's disease

Autor: Sandborn, Wj, Gasink, C, Gao, Ll, Blank, Ma, Johanns, J, Guzzo, C, Sands, Be, Hanauer, Sb, Targan, S, Rutgeerts, P, Ghosh, S, de Villiers WJ, Panaccione, R, Greenberg, G, Schreiber, S, Lichtiger, S, Feagan, Bg, Haas, T, Kaser, A, Vogelsang, H, Brown, S, Florin, T, Gibson, Pg, Hetzel, D, Leong, R, Pavli, P, Radford-Smith, G, Sparrow, M, Baert, F, D'Haens, G, D'Heygere, F, Franchimont, D, Louis, E, Mana, F, Moreels, T, Vermeire, S, Anderson, F, Axler, J, Greenbloom, S, Bitton, A, Fedorak, Rn, Larkai, E, Marshall, J, Singh, R, Abitbol, V, Allez, M, Lemann, M, Bonaz, B, Colombel, Jf, Dupas, Jl, Hebuterne, X, Laharie, D, Lerebours, E, Moreau, J, Bokemeyer, B, Holler, B, Howaldt, Sp, Krummenerl, T, Kucharzik, T, Ochsenkühn, T, Raedler, A, Schiefke, I, Seidler, U, Sturm, A, Zeitz, M, Eliakim, A, Fishman, S, Konikoff, Fm, Lavy, A, Niv, Y, Nussinson, E, Rachmilewitz, D, Andriulli, A, Annese, V, Biancone, L, Corazza, Gr, Danese, S, Sturniolo, Gc, Terrosu, G, Sorrentino, D, Hommes, Dw, Jansen, Jm, Otten, Mh, Pierik, M, Ponsioen, Cy, Stokkers, P, van Bodegraven AA, Van der Woude, J, Calvet Calvo, X, Casellas, F, Garcia López, S, Garcia-Planella, E, Ginard-Vincens, D, López San Román, A, Muñoz Nuñez, F, Pérez Gisbert, J, Vera, Mi, Rodrigo, J, Riestra-Menendez, S, Arnott, I, Bloom, S, Campbell, Ss, Harbord, Mw, Mansfield, Jc, Nwokolo, C, Parkes, M, Probert, Cs, Aberra, Fn, Abraham, Bp, Abreu, Mt, Amontree, Js, Barish, Cf, Barto, Ae, Behm, B, Birbara, Ca, Bologna, S, Dryden GW Jr, Eisner, Ms, Ertan, A, Fogel, R, Gagneja, Hk, Ginsburg, P, Goff, Js, Gordon, G, Hamilton, Jw, Hanson, Js, Hardi, R, Hemaidan, A, Higgins, P, Holderman, W, Hornbuckle, K, Ibegbu, E, Isaacs, Kl, Katz, Ja, Katz, S, Kaufman, Bp, Kavanaugh, Af, Khurana, Sk, Lashner, B, Lawrence, S, Hansen, Rn, Lee, S, Leighton, Ja, Leman, Bi, Levenson, Sd, Lowe, Je, Marcuard, Sp, Matsuyama, Rm, Mcnair, Ae, Melmed, G, Miller, Km, Miner PB Jr, Mutlu, Ea, Keshavarzian, A, Narayen, V, Noar, Md, Patel, Ph, Patrick, Tj, Peck, A, Peterson, Ka, Phillips, Rw, Picco, Mf, Randall, C, Richards, Rj, Safdi, Ma, Scherl, Eh, Schwartz, Da, Schwartz, Hi, Schwartz, Jl, Sedghi, S, Shafran, I, Siegel, Ca, Sninsky, Ca, Stern, M, Suiter, D, Swaminath, A, Terdiman, Jp, Mahadevan, U, Thomson, C, Valentine, J, Vasudeva, R, Vecchio, Ja, Wolf, Dc, Yajnik, V, Yabkowski, J, Yen, E.

Publikováno v: New England journal of medicine, 367(16), 1519-1528. Massachussetts Medical Society
NEW ENGLAND JOURNAL OF MEDICINE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

BACKGROUND In patients with Crohn's disease, the efficacy of ustekinumab, a human monoclonal antibody against interleukin-12 and interleukin-23, is unknown. METHODS We evaluated ustekinumab in adults with moderate-to-severe Crohn's disease that was r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61da68785d51749a18aadbbf4b6659fb
https://pure.amc.nl/en/publications/ustekinumab-induction-and-maintenance-therapy-in-refractory-crohns-disease(84ddd6f0-9401-4834-97b2-0878006f55e3).html

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Safety, Pharmacokinetics, and Efficacy of Olorinab, a Peripherally Acting, Highly Selective, Full Agonist of the Cannabinoid Receptor 2, in a Phase 2a Study of Patients With Chronic Abdominal Pain Associated With Crohn's Disease.

Autor: Yacyshyn BR; Department of Gastroenterology, University of Cincinnati, Cincinnati, Ohio, USA., Hanauer S; Department of Gastroenterology and Hepatology, Northwestern University, Chicago, Illinois, USA., Klassen P; Arena Pharmaceuticals Inc., Research and Development, San Diego, California, USA., English BA; Arena Pharmaceuticals Inc., Clinical Development, San Diego, California, USA., Stauber K; Arena Pharmaceuticals Inc., Nonclinical Development and Clinical Pharmacology, San Diego, California, USA., Barish CF; Department of Gastroenterology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Gilder K; Arena Pharmaceuticals Inc., Biostatistics and Data Management, San Diego, California, USA., Turner S; Arena Pharmaceuticals Inc., Olorinab Global Program Lead, San Diego, California, USA., Higgins PDR; Department of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA.

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A phase III study evaluating the efficacy and safety of remimazolam (CNS 7056) compared with placebo and midazolam in patients undergoing colonoscopy.

Autor: Rex DK; Indiana University School of Medicine, Indianapolis, Indianapolis., Bhandari R; Delta Research Partners, Monroe, Louisiana., Desta T; Precision Research Institute, San Diego., DeMicco MP; Advanced Clinical Research Institute, Anaheim., Schaeffer C; Precision Research Institute, Chula Vista, California., Etzkorn K; Borland-Groover Clinic, Jacksonville, Florida., Barish CF; Wake Research Associates, Raleigh, North Carolina., Pruitt R; Nashville Medical Research Institute, Nashville, Tennessee., Cash BD; University of South Alabama, Mobile, Alabama., Quirk D; Thomas Jefferson Medical College, Philadelphia, Pennsylvania., Tiongco F; Gastroenterology Associates of Tidewater, Chesapeake, Virginia., Sullivan S; Department of Medicine, University of Colorado, Denver, Colorado., Bernstein D; Hofstra Northwell School of Medicine, Hempstead, New York.

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Epitope-specific immunotherapy targeting CD4-positive T cells in coeliac disease: two randomised, double-blind, placebo-controlled phase 1 studies.

Autor: Goel G; Division of Gastroenterology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., King T; Department of Gastroenterology, Auckland City Hospital, Auckland, New Zealand., Daveson AJ; School of Medicine, University of Queensland, Brisbane, QLD, Australia., Andrews JM; Department of Gastroenterology & Hepatology, Royal Adelaide Hospital, Adelaide, SA, Australia., Krishnarajah J; Linear Clinical Research, Nedlands, WA, Australia., Krause R; ClinSearch, Chattanooga, TN, USA., Brown GJE; Department of Gastroenterology, Alfred Hospital, Prahran, VIC, Australia., Fogel R; Clinical Research Institute of Michigan, Chesterfield, MI, USA., Barish CF; University of North Carolina School of Medicine, Chapel Hill, NC, USA; Wake Gastroenterology and Wake Research Associates, Raleigh, NC, USA., Epstein R; Atlantic Digestive Specialists, Portsmouth, NH, USA., Kinney TP; Ridgeview Medical Center, Waconia, MN, USA., Miner PB Jr; Oklahoma Foundation for Digestive Research, Oklahoma City, OK, USA., Tye-Din JA; Immunology Division, Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia; Murdoch Children's Research Institute and Department of Gastroenterology, Royal Melbourne Hospital, Parkville, VIC, Australia., Girardin A; Immunology Division, Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Taavela J; Tampere Center for Child Health Research and Department of Pediatrics, University of Tampere Faculty of Medicine and Life Sciences and Tampere University Hospital, Tampere, Finland., Popp A; Tampere Center for Child Health Research and Department of Pediatrics, University of Tampere Faculty of Medicine and Life Sciences and Tampere University Hospital, Tampere, Finland; Alfred Rusescu Institute for Mother and Child Care and Carol Davila University of Medicine and Pharmacy, Bucharest, Romania., Sidney J; Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA., Mäki M; Tampere Center for Child Health Research and Department of Pediatrics, University of Tampere Faculty of Medicine and Life Sciences and Tampere University Hospital, Tampere, Finland., Goldstein KE; ImmusanT, Cambridge, MA, USA., Griffin PH; ImmusanT, Cambridge, MA, USA., Wang S; ImmusanT, Cambridge, MA, USA., Dzuris JL; ImmusanT, Cambridge, MA, USA., Williams LJ; ImmusanT, Cambridge, MA, USA., Sette A; Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA., Xavier RJ; Division of Gastroenterology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Sollid LM; Centre for Immune Regulation, KG Jebsen Coeliac Disease Research Centre, and Department of Immunology, University of Oslo, Oslo, Norway; Oslo University Hospital-Rikshospitalet, Oslo, Norway., Jabri B; Department of Pediatrics, Department of Medicine, University of Chicago, Chicago, IL, USA., Anderson RP; ImmusanT, Cambridge, MA, USA. Electronic address: bob@immusant.com.

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