Analysis of cellular water content in T cells reveals a switch from slow metabolic water gain to rapid water influx prior to cell division

Autor: Saragovi, A., Zilberman, T., Yasur, G., Turjeman, K., Abramovich, I., Kuchersky, M., Gottlieb, E., Barenholz, Y., Berger, M.

Publikováno v: In Journal of Biological Chemistry April 2022 298(4)

Nano-mupirocin as tumor-targeted antibiotic: Physicochemical, immunotoxicological and pharmacokinetic characterization, and effect on gut microbiome.

Autor: Cern A; Laboratory of Membrane and Liposome Research, Department of Biochemistry, The Hebrew University of Jerusalem, Israel. Electronic address: ahuva.cern@mail.huji.ac.il., Skoczen SL; Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, MD, USA., Snapp KS; Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, MD, USA., Hod A; Laboratory of Membrane and Liposome Research, Department of Biochemistry, The Hebrew University of Jerusalem, Israel., Zilbersheid D; Laboratory of Membrane and Liposome Research, Department of Biochemistry, The Hebrew University of Jerusalem, Israel., Bavli Y; Laboratory of Membrane and Liposome Research, Department of Biochemistry, The Hebrew University of Jerusalem, Israel., Alon-Maimon T; The Institute of Dental Sciences, The Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel., Bachrach G; The Institute of Dental Sciences, The Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel., Wei X; School of Pharmacy, Shanghai Jiao Tong University, China., Berman B; Microbiology & Molecular Genetics Department, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Yassour M; Microbiology & Molecular Genetics Department, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel; The Rachel and Selim Benin School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel., Cedrone E; Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, MD, USA., Neun BW; Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, MD, USA., Dobrovolskaia MA; Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, MD, USA., Clogston JD; Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, MD, USA., Stern ST; Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, MD, USA., Barenholz Y; Laboratory of Membrane and Liposome Research, Department of Biochemistry, The Hebrew University of Jerusalem, Israel.

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2024 Sep; Vol. 373, pp. 713-726. Date of Electronic Publication: 2024 Aug 02.

Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions.

Autor: Anchordoquy T; Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, the University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, United States., Artzi N; Brigham and Woman's Hospital, Department of Medicine, Division of Engineering in Medicine, Harvard Medical School, Boston, Massachusetts 02215, United States.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02215, United States.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02215, United States., Balyasnikova IV; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States., Barenholz Y; Membrane and Liposome Research Lab, IMRIC, Hebrew University Hadassah Medical School, Jerusalem 9112102, Israel., La-Beck NM; Department of Immunotherapeutics and Biotechnology, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, Texas 79601, United States., Brenner JS; Departments of Medicine and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Chan WCW; Institute of Biomedical Engineering, University of Toronto, Rosebrugh Building, 164 College Street, Toronto, Ontario M5S 3G9, Canada.; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada., Decuzzi P; Laboratory of Nanotechnology for Precision Medicine, Italian Institute of Technology, 16163 Genova, Italy., Exner AA; Departments of Radiology and Biomedical Engineering, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, United States., Gabizon A; The Helmsley Cancer Center, Shaare Zedek Medical Center and The Hebrew University of Jerusalem-Faculty of Medicine, Jerusalem, 9103102, Israel., Godin B; Department of Nanomedicine, Houston Methodist Research Institute, Houston, Texas 77030, United States.; Department of Obstetrics and Gynecology, Houston Methodist Hospital, Houston, Texas 77030, United States.; Department of Obstetrics and Gynecology, Weill Cornell Medicine College (WCMC), New York, New York 10065, United States.; Department of Biomedical Engineering, Texas A&M, College Station, Texas 7784,3 United States., Lai SK; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27599, United States., Lammers T; Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, Center for Biohybrid Medical Systems, University Hospital RWTH Aachen, 52074 Aachen, Germany., Mitchell MJ; Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Moghimi SM; School of Pharmacy, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.; Translational and Clinical Research Institute, Faculty of Health and Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, U.K.; Colorado Center for Nanomedicine and Nanosafety, University of Colorado Anschutz Medical Center, Aurora, Colorado 80045, United States., Muzykantov VR; Department of Systems Pharmacology and Translational Therapeutics, The Perelman School of Medicine, The University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Peer D; Laboratory of Precision Nanomedicine, Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 69978, Israel.; Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv, 69978, Israel.; Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, 69978, Israel.; Cancer Biology Research Center, Tel Aviv University, Tel Aviv, 69978, Israel., Nguyen J; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27599, United States., Popovtzer R; Faculty of Engineering and the Institute of Nanotechnology & Advanced Materials, Bar-Ilan University, 5290002 Ramat Gan, Israel., Ricco M; Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, the University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, United States., Serkova NJ; Department of Radiology, University of Colorado Cancer Center, Anschutz Medical Campus, Aurora, Colorado 80045, United States., Singh R; Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27101, United States.; Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina 27101, United States., Schroeder A; Department of Chemical Engineering, Technion, Israel Institute of Technology, Haifa 32000, Israel., Schwendeman AA; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48108; Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan 48108, United States., Straehla JP; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts 02115 United States.; Koch Institute for Integrative Cancer Research at MIT, Cambridge Massachusetts 02139 United States., Teesalu T; Laboratory of Precision and Nanomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411 Tartu, Estonia., Tilden S; Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, the University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, United States., Simberg D; Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, the University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, United States.

Publikováno v: ACS nano [ACS Nano] 2024 Jun 04; Vol. 18 (22), pp. 13983-13999. Date of Electronic Publication: 2024 May 20.

Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccines.

Autor: Szebeni J; Nanomedicine Research and Education Center, Institute of Translational Medicine, Semmelweis University, Budapest, Hungary.; SeroScience LCC, Budapest, Hungary.; Department of Nanobiotechnology and Regenerative Medicine, Faculty of Health, Miskolc University, Miskolc, Hungary., Storm G; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University, Utrecht, the Netherlands.; Department of Biomaterials Science and Technology, University of Twente, Enschede, the Netherlands.; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Ljubimova JY; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, USA., Castells M; Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Phillips EJ; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Turjeman K; Laboratory of Membrane and Liposome Research, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel., Barenholz Y; Laboratory of Membrane and Liposome Research, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel., Crommelin DJA; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University, Utrecht, the Netherlands., Dobrovolskaia MA; Nanotechnology Characterization Laboratory, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, MD, USA. marina@mail.nih.gov.

Publikováno v: Nature nanotechnology [Nat Nanotechnol] 2022 Apr; Vol. 17 (4), pp. 337-346. Date of Electronic Publication: 2022 Apr 07.

Insights into the Structure of Comirnaty Covid-19 Vaccine: A Theory on Soft, Partially Bilayer-Covered Nanoparticles with Hydrogen Bond-Stabilized mRNA-Lipid Complexes.

Autor: Szebeni J; Nanomedicine Research and Education Center, Department of Translational Medicine, Semmelweis University, Budapest 1089, Hungary.; Department of Nanobiotechnology and Regenerative Medicine, Faculty of Health Sciences, Miskolc University, Miskolc 2880, Hungary.; School of Chemical Engineering and Translational Nanobioscience Research Center, Sungkyunkwan University, Suwon 16419, Korea., Kiss B; Department of Biophysics and Radiation Biology, Semmelweis University, Budapest 1094, Hungary.; Hungarian Centre of Excellence for Molecular Medicine (HCEMM), In Vivo Imaging Advanced Core Facility, Budapest 1094, Hungary.; ELKH-SE Biophysical Virology Research Group, Budapest 1094, Hungary., Bozó T; Department of Biophysics and Radiation Biology, Semmelweis University, Budapest 1094, Hungary.; Hungarian Centre of Excellence for Molecular Medicine (HCEMM), In Vivo Imaging Advanced Core Facility, Budapest 1094, Hungary., Turjeman K; The Laboratory of Membrane and Liposome Research, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem 9112102, Israel., Levi-Kalisman Y; Institute of Life Sciences and the Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel., Barenholz Y; The Laboratory of Membrane and Liposome Research, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem 9112102, Israel., Kellermayer M; Department of Biophysics and Radiation Biology, Semmelweis University, Budapest 1094, Hungary.; Hungarian Centre of Excellence for Molecular Medicine (HCEMM), In Vivo Imaging Advanced Core Facility, Budapest 1094, Hungary.; ELKH-SE Biophysical Virology Research Group, Budapest 1094, Hungary.

Publikováno v: ACS nano [ACS Nano] 2023 Jul 25; Vol. 17 (14), pp. 13147-13157. Date of Electronic Publication: 2023 Jul 07.