Genome-scale metabolic network of human carotid plaque reveals the pivotal role of glutamine/glutamate metabolism in macrophage modulating plaque inflammation and vulnerability

Autor: Han Jin, Cheng Zhang, Jan Nagenborg, Peter Juhasz, Adele V. Ruder, Cornelis J. J. M. Sikkink, Barend M. E. Mees, Olivia Waring, Judith C. Sluimer, Dietbert Neumann, Pieter Goossens, Marjo M. P. C. Donners, Adil Mardinoglu, Erik A. L. Biessen

Publikováno v: Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-17 (2024)

Abstract Background Metabolism is increasingly recognized as a key regulator of the function and phenotype of the primary cellular constituents of the atherosclerotic vascular wall, including endothelial cells, smooth muscle cells, and inflammatory c

Externí odkaz: https://doaj.org/article/abf30882fa56414492f4965ea2f6957e

Antithrombotic Therapy for Symptomatic Peripheral Arterial Disease: A Systematic Review and Network Meta-Analysis

Autor: Loes H. Willems, Dominique P. M. S. M. Maas, Kees Kramers, Michel M. P. J. Reijnen, Niels P. Riksen, Hugo Ten Cate, Rozemarijn J. van der Vijver-Coppen, Gert J. de Borst, Barend M. E. Mees, Clark J. Zeebregts, Gerjon Hannink, Michiel C. Warlé

Publikováno v: Drugs, 82, 12, pp. 1287-1302
Drugs, 82, 1287-1302

Contains fulltext : 282329.pdf (Publisher’s version ) (Open Access) BACKGROUND: High-quality evidence from trials directly comparing single antiplatelet therapies in symptomatic peripheral arterial disease (PAD) to dual antiplatelet therapies or ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca6a91307df9b6d49fc022eaa86e310
https://doi.org/10.1007/s40265-022-01756-6

Human and murine fibroblast single-cell transcriptomics reveals fibroblast clusters are differentially affected by ageing and serum cholesterol

Autor: Kim van Kuijk, Ian R McCracken, Renée J H A Tillie, Sebastiaan E J Asselberghs, Dlzar A Kheder, Stan Muitjens, Han Jin, Richard S Taylor, Ruud Wichers Schreur, Christoph Kuppe, Ross Dobie, Prakesh Ramachandran, Marion J Gijbels, Lieve Temmerman, Phoebe M Kirkwoord, Joris Luyten, Yanming Li, Heidi Noels, Pieter Goossens, John R Wilson-Kanamori, Leon J Schurgers, Ying H Shen, Barend M E Mees, Erik A L Biessen, Neil C Henderson, Rafael Kramann, Andrew H Baker, Judith C Sluimer

Publikováno v: van Kuijk, K, McCracken, I, Tillie, RJHA, Asselberghs, SEJ, Kheder, DA, Muitjens, S, Jin, H, Taylor, R S, Wichers Schreur, R, Kuppe, C, Dobie, R, Ramachandran, P, Gijbels, M J, Temmerman, L, Kirkwoord, PM, Luyten, J, Li, Y, Noels, H, Goossens, P, Wilson-Kanamori, J R, Schurgers, L J, Shen, YH, Mees, BME, Biessen, E A L, Henderson, N C, Kramann, R, Baker, A H & Sluimer, J 2023, ' Human and murine fibroblast single cell transcriptomics reveals fibroblast clusters are differentially affected by ageing, and serum cholesterol ', Cardiovascular Research . https://doi.org/10.1093/cvr/cvad016

Aims Specific fibroblast markers and in-depth heterogeneity analysis are currently lacking, hindering functional studies in cardiovascular diseases (CVDs). Here, we established cell-type markers and heterogeneity in murine and human arteries and stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4284963a76fbdd9b58b41521f19806b5
https://doi.org/10.1093/cvr/cvad016

Association of Hospital Volume with Perioperative Mortality of Endovascular Repair of Complex Aortic Aneurysms: A Nationwide Cohort Study

Autor: Anna J, Alberga, Gerdine C I, von Meijenfeldt, Vinamr, Rastogi, Jorg L, de Bruin, Jan J, Wever, Joost A, van Herwaarden, Jaap F, Hamming, Constantijn E V B, Hazenberg, Jan, van Schaik, Barend M E, Mees, Maarten J, van der Laan, Clark J, Zeebregts, Geert W H, Schurink, Hence J M, Verhagen

Publikováno v: Annals of surgery.

We evaluate nationwide perioperative outcomes of complex EVAR and assess the volume-outcome association of complex EVAR.Endovascular treatment with fenestrated (FEVAR) or branched (BEVAR) endografts is progressively used for excluding complex aortic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6da9dadf43c7d4456d0a069e72a59dcb
https://pubmed.ncbi.nlm.nih.gov/34913891

Towards individualized follow-up protocols after endovascular aortic aneurysm repair

Autor: Johanna, Laturnus, Nelson, Oliveira, Frederico, Basto Gonçalves, Geert W, Schurink, Hence, Verhagen, Michael J, Jacobs, Barend M E, Mees

Publikováno v: The Journal of cardiovascular surgery. 57(2)

Endovascular aneurysm repair (EVAR) has become the primary treatment option for elective abdominal aortic aneurysms. However, a significant number of patients require secondary interventions to maintain adequate aneurysm exclusion and ultimately prev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f1b989b94bada7b508203d9ae692eb36
https://pubmed.ncbi.nlm.nih.gov/26745264