Inducible hepatic expression of CREBH mitigates diet-induced obesity, insulin resistance, and hepatic steatosis in mice.

Autor: Krumm CS; Division of Gastroenterology & Hepatology, Joan & Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, New York, USA., Xu X; Division of Gastroenterology & Hepatology, Joan & Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, New York, USA., Bare CJ; Division of Gastroenterology & Hepatology, Joan & Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, New York, USA., Holman CD; Division of Gastroenterology & Hepatology, Joan & Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, New York, USA., Kersten S; Nutrition, Metabolism, and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, the Netherlands., Dow LE; Division of Hematology & Medical Oncology, Joan & Sanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medical College, New York, New York, USA., Lee AH; Department of Pathology & Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA., Cohen DE; Division of Gastroenterology & Hepatology, Joan & Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, New York, USA. Electronic address: dcohen@med.cornell.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2021 Jul; Vol. 297 (1), pp. 100815. Date of Electronic Publication: 2021 May 21.

Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity.

Autor: Sinden DS; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA.; Cardiovascular Research Institute, Weill Cornell Medical College, New York, New York, USA., Holman CD; Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, New York, USA., Bare CJ; Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, New York, USA., Sun X; Cardiovascular Research Institute, Weill Cornell Medical College, New York, New York, USA., Gade AR; Cardiovascular Research Institute, Weill Cornell Medical College, New York, New York, USA., Cohen DE; Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, New York, USA., Pitt GS; Cardiovascular Research Institute, Weill Cornell Medical College, New York, New York, USA.

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2019 Oct; Vol. 33 (10), pp. 11579-11594. Date of Electronic Publication: 2019 Jul 24.

Nutritional Support from the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice.

Autor: Staffas A; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Burgos da Silva M; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Slingerland AE; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Lazrak A; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Bare CJ; Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY 10021, USA., Holman CD; Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY 10021, USA., Docampo MD; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunology and Microbial Pathogenesis, Weill Cornell Medical College, New York, NY 10065, USA., Shono Y; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Durham B; Human Oncology and Pathogenesis Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Pickard AJ; Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Cross JR; Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Stein-Thoeringer C; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Velardi E; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Tsai JJ; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Jahn L; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Jay H; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Lieberman S; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Smith OM; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Pamer EG; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Medical College, New York, NY 10065, USA; Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Lucille Castori Center for Microbes, Inflammation, and Cancer, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Peled JU; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Medical College, New York, NY 10065, USA; Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Cohen DE; Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY 10021, USA., Jenq RR; Departments of Genomic Medicine and Stem Cell Transplantation Cellular Therapy, Division of Cancer Medicine, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA., van den Brink MRM; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Medical College, New York, NY 10065, USA; Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: vandenbm@mskcc.org.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2018 Apr 11; Vol. 23 (4), pp. 447-457.e4. Date of Electronic Publication: 2018 Mar 22.

Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.

Autor: Kazak L; Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Cell Biology, Harvard University Medical School, Boston, MA 02115, USA. Electronic address: lawrence.kazak@mcgill.ca., Chouchani ET; Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Cell Biology, Harvard University Medical School, Boston, MA 02115, USA., Lu GZ; Dana-Farber Cancer Institute, Boston, MA 02115, USA., Jedrychowski MP; Department of Cell Biology, Harvard University Medical School, Boston, MA 02115, USA., Bare CJ; Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Mina AI; Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Kumari M; Division of Endocrinology, Beth Israel Deaconess Medical Center and Department of Genetics, Harvard Medical School, Boston, MA 02215, USA., Zhang S; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Vuckovic I; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Laznik-Bogoslavski D; Dana-Farber Cancer Institute, Boston, MA 02115, USA., Dzeja P; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Banks AS; Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Rosen ED; Division of Endocrinology, Beth Israel Deaconess Medical Center and Department of Genetics, Harvard Medical School, Boston, MA 02215, USA., Spiegelman BM; Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Cell Biology, Harvard University Medical School, Boston, MA 02115, USA. Electronic address: bruce_spiegelman@dfci.harvard.edu.

Publikováno v: Cell metabolism [Cell Metab] 2017 Oct 03; Vol. 26 (4), pp. 660-671.e3. Date of Electronic Publication: 2017 Aug 24.

Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease.

Autor: Allen GI; Department of Statistics and Electrical and Computer Engineering, Rice University, Houston, TX, USA., Amoroso N; Dipartimento di Fisica 'M. Merlin', Università degli studi di Bari 'A. Moro', Bari, Italy; Sezione di Bari, Istituto Nazionale di Fisica Nucleare, Bari, Italy., Anghel C; Ontario Institute for Cancer Research, Informatics and Bio-computing Program, MaRS Centre, Toronto, ON, Canada., Balagurusamy V; IBM Computational Biology Center, IBM Research, NY, USA., Bare CJ; Sage Bionetworks, Seattle, WA, USA., Beaton D; School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, USA., Bellotti R; Dipartimento di Fisica 'M. Merlin', Università degli studi di Bari 'A. Moro', Bari, Italy; Sezione di Bari, Istituto Nazionale di Fisica Nucleare, Bari, Italy., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Boehme KL; Department of Biology, Brigham Young University, Provo, UT, USA., Boutros PC; Ontario Institute for Cancer Research, Informatics and Bio-computing Program, MaRS Centre, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Canada., Caberlotto L; The Microsoft Research, University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy., Caloian C; Ontario Institute for Cancer Research, Informatics and Bio-computing Program, MaRS Centre, Toronto, ON, Canada., Campbell F; Department of Statistics and Electrical and Computer Engineering, Rice University, Houston, TX, USA., Chaibub Neto E; Sage Bionetworks, Seattle, WA, USA., Chang YC; Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan., Chen B; Quantitative Biomedical Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Chen CY; Department of Bio-Industrial Mechatronics Engineering, National Taiwan University, Taipei, Taiwan., Chien TY; Innovation Center for Big Data and Digital Convergence, Yuan Ze University, Taoyuan, Taiwan., Clark T; Department of Neurology, Massachusetts General Hospital, Cambridge, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA., Das S; Department of Neurology, Massachusetts General Hospital, Cambridge, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA., Davatzikos C; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA., Deng J; School of Computer Science, Fudan University, Shanghai, Shanghai, China; Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, Shanghai, China., Dillenberger D; IBM Computational Biology Center, IBM Research, NY, USA., Dobson RJ; NIHR Biomedical Research Centre for Mental Health, Kings College London, London, UK; Institute of Psychiatry, Psychology and Neuroscience, MRC Social, Genetic and Developmental Psychiatry Centre, Kings College London, London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, London WC1E 6BT, UK., Dong Q; School of Computer Science, Fudan University, Shanghai, Shanghai, China; Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, Shanghai, China., Doshi J; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA., Duma D; Department of Pediatrics-Neurology, Baylor College of Medicine, Houston, TX, USA., Errico R; Università degli Studi di Genova, Genova, Italy., Erus G; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA., Everett E; Department of Statistics and Electrical and Computer Engineering, Rice University, Houston, TX, USA., Fardo DW; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Biostatistics, University of Kentucky, Lexington, KY, USA., Friend SH; Sage Bionetworks, Seattle, WA, USA., Fröhlich H; Bonn-Aachen International Center for IT, University of Bonn, Bonn, Germany., Gan J; Department of Statistics and Electrical and Computer Engineering, Rice University, Houston, TX, USA., St George-Hyslop P; Cambridge Institute for Medical Research, University of Cambridge and University of Toronto, Cambridge, CB2, UK., Ghosh SS; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA., Glaab E; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg., Green RC; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Broad Institute and Harvard Medical School, Boston, MA, USA., Guan Y; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA; Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA., Hong MY; Department of Bio-Industrial Mechatronics Engineering, National Taiwan University, Taipei, Taiwan., Huang C; Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Hwang J; Department of Computer science and Statistics, Daegu University, Gyeongsan-si, Gyeongsangbuk-do, Republic of Korea., Ibrahim J; Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Inglese P; Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK., Iyappan A; Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Department for Bioinformatics, Schloss Birlinghoven, Sankt Augustin, Germany; Bonn-Aachen International Center for IT, University of Bonn, Bonn, Germany., Jiang Q; Department of Statistics and Electrical and Computer Engineering, Rice University, Houston, TX, USA., Katsumata Y; Department of Biostatistics, University of Kentucky, Lexington, KY, USA., Kauwe JS; Department of Biology, Brigham Young University, Provo, UT, USA. Electronic address: kauwe@byu.edu., Klein A; Sage Bionetworks, Seattle, WA, USA. Electronic address: arno@binarybottle.com., Kong D; Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Krause R; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg., Lalonde E; Ontario Institute for Cancer Research, Informatics and Bio-computing Program, MaRS Centre, Toronto, ON, Canada., Lauria M; The Microsoft Research, University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy., Lee E; Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Lin X; Ontario Institute for Cancer Research, Informatics and Bio-computing Program, MaRS Centre, Toronto, ON, Canada., Liu Z; Department of Statistics and Electrical and Computer Engineering, Rice University, Houston, TX, USA., Livingstone J; Ontario Institute for Cancer Research, Informatics and Bio-computing Program, MaRS Centre, Toronto, ON, Canada., Logsdon BA; Sage Bionetworks, Seattle, WA, USA., Lovestone S; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK., Ma TW; Quantitative Biomedical Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Malhotra A; Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Department for Bioinformatics, Schloss Birlinghoven, Sankt Augustin, Germany; Bonn-Aachen International Center for IT, University of Bonn, Bonn, Germany., Mangravite LM; Sage Bionetworks, Seattle, WA, USA. Electronic address: lara.mangravite@sagebase.org., Maxwell TJ; Computational Biology Institute, The George Washington University, Ashburn, VA, USA., Merrill E; Department of Neurology, Massachusetts General Hospital, Cambridge, MA, USA., Nagorski J; Department of Statistics and Electrical and Computer Engineering, Rice University, Houston, TX, USA., Namasivayam A; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg., Narayan M; Department of Statistics and Electrical and Computer Engineering, Rice University, Houston, TX, USA., Naz M; Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Department for Bioinformatics, Schloss Birlinghoven, Sankt Augustin, Germany; Bonn-Aachen International Center for IT, University of Bonn, Bonn, Germany., Newhouse SJ; NIHR Biomedical Research Centre for Mental Health, Kings College London, London, UK; Department of Biostatistics, Kings College London, London, UK., Norman TC; Sage Bionetworks, Seattle, WA, USA., Nurtdinov RN; Department of Neuroimmunology, Foundation Institut de Recerca, Hospital Universitari Vall d'Hebron, Barcelona, Spain., Oyang YJ; Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan., Pawitan Y; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Peng S; School of Computer Science, Fudan University, Shanghai, Shanghai, China; Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, Shanghai, China., Peters MA; Sage Bionetworks, Seattle, WA, USA. Electronic address: mette.peters@sagebase.org., Piccolo SR; Department of Biology, Brigham Young University, Provo, UT, USA., Praveen P; The Microsoft Research, University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy; Bonn-Aachen International Center for IT, University of Bonn, Bonn, Germany., Priami C; The Microsoft Research, University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy., Sabelnykova VY; Ontario Institute for Cancer Research, Informatics and Bio-computing Program, MaRS Centre, Toronto, ON, Canada., Senger P; Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Department for Bioinformatics, Schloss Birlinghoven, Sankt Augustin, Germany., Shen X; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK; MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Simmons A; NIHR Biomedical Research Centre for Mental Health, Kings College London, London, UK., Sotiras A; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA., Stolovitzky G; Genetics and Genomics Sciences Department, Icahn School of Medicine at Mount Sinai, New York, NY, USA; IBM Computational Biology Center, IBM Research, NY, USA., Tangaro S; Sezione di Bari, Istituto Nazionale di Fisica Nucleare, Bari, Italy., Tateo A; Dipartimento di Fisica 'M. Merlin', Università degli studi di Bari 'A. Moro', Bari, Italy., Tung YA; Genome and systems biology degree program, National Taiwan University, Taipei, Taiwan., Tustison NJ; Department of Radiology and Medical Imaging, The University of Virginia, Charlottesville, VA, USA., Varol E; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA., Vradenburg G; Global CEO Initiative on Alzheimer's disease, Washington, DC, USA., Weiner MW; Radiology, Medicine, Psychiatry, and Neurology, UCSF, SFVAMC, San Francisco, CA, USA., Xiao G; Quantitative Biomedical Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Xie L; Department of Computer Science, Hunter College, The City University of New York, New York, NY, USA., Xie Y; Quantitative Biomedical Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Xu J; Quantitative Biomedical Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Yang H; Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Zhan X; Quantitative Biomedical Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Zhou Y; Quantitative Biomedical Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Zhu F; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Zhu H; Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Zhu S; School of Computer Science, Fudan University, Shanghai, Shanghai, China; Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, Shanghai, China; Centre for Computational Systems Biology, Fudan University, Shanghai, China.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2016 Jun; Vol. 12 (6), pp. 645-53. Date of Electronic Publication: 2016 Apr 11.