Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Barden Timothy Claude"'
Autor:
Jia Lei, Joon Jung, Sylvie G. Bernier, Joel D. Moore, Glen Rennie, Mermerian Ara, Nicholas Robert Perl, Thomas Wai-Ho Lee, Andrew Carvalho, Barden Timothy Claude, Peter Germano, Jenny Tobin, Colleen Hudson, Renee Deming, Rajesh R. Iyengar, Takashi Nakai, G-Yoon Jamie Im, Paul A. Renhowe, Daniel P. Zimmer, Elise Kim
Publikováno v:
Bioorganicmedicinal chemistry letters. 40
Soluble guanylate cyclase (sGC) is a clinically validated therapeutic target in the treatment of pulmonary hypertension. Modulators of sGC have the potential to treat diseases that are affected by dysregulation of the NO-sGC-cGMP signal transduction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9de2bad2e2d41649c98451bf1e9a94
https://pubmed.ncbi.nlm.nih.gov/33662540
https://pubmed.ncbi.nlm.nih.gov/33662540
Autor:
Jenny Tobin, Albert T. Profy, Ali R. Banijamali, Mark G. Currie, James Wakefield, Jaime L. Masferrer, G. Todd Milne, Daniel P. Zimmer, Andrew Carvalho, Peter Germano, Barden Timothy Claude
Publikováno v:
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives, Vol 8, Iss 2, Pp n/a-n/a (2020)
Pharmacology Research & Perspectives, Vol 8, Iss 2, Pp n/a-n/a (2020)
The pharmacokinetics (PK), metabolism, excretion, mass balance, and tissue distribution of [14C]praliciguat were evaluated following oral administration of a 3‐mg/kg dose in Sprague‐Dawley rats and in a quantitative whole‐body autoradiography (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b3e4df24159164c127118e8e21c0b4
http://europepmc.org/articles/PMC7171252
http://europepmc.org/articles/PMC7171252
Autor:
Ara Mermerian, Karthik Iyer, Takashi Nakai, Daniel P. Zimmer, Thomas W.-H. Lee, Kimberly Kafadar Long, Peter Germano, Sylvie G. Bernier, Joon Jung, Chrissie Segal, Yueh-Tyng Chien, G. Todd Milne, G-Yoon Jamie Im, Sarah Jacobson, Jenny Tobin, Barden Timothy Claude, Joy Miyashiro, Nicholas Robert Perl, Paul Allan Renhowe, Courtney Shea, James Jia, Rajesh R. Iyengar, James E. Sheppeck, Rennie Glen Robert
Publikováno v:
BMC Pharmacology & Toxicology
Discovery of IWP-051, a novel orally bioavailable soluble guanylate cyclase stimulator with sustained and dose-dependent hemodynamic effects Takashi Nakai, Nicholas R Perl, Rajesh R Iyengar, Ara Mermerian, G-Yoon J Im, Thomas W-H Lee, Glen R Rennie,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb868ebda744713069bdf24ee150fb37
http://europepmc.org/articles/PMC4565103
http://europepmc.org/articles/PMC4565103