Outcomes with intensive treatment for acute myeloid leukemia: an analysis of two decades of data from the HARMONY Alliance.

Autor: Sobas MA; Department of Hematology, Blood Neoplasm and Bone Marrow Transplantation, Wroclaw Medical University., Turki AT; Department of Hematology and Oncology, Marienhospital University Hospital, Ruhr-University Bochum, Bochum., Ramiro AV; Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain; Cancer Research Center of Salamanca (USAL-CSIC), Salamanca., Hernández-Sánchez A; Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain; Cancer Research Center of Salamanca (USAL-CSIC), Salamanca, Spain; Hematology Department, University Hospital of Salamanca, Salamanca., Elicegui JM; Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain; Cancer Research Center of Salamanca (USAL-CSIC), Salamanca., González T; Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain; Cancer Research Center of Salamanca (USAL-CSIC), Salamanca., Melchor RA; Hematology Department, University Hospital of Salamanca, Salamanca., Abáigar M; Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain; Cancer Research Center of Salamanca (USAL-CSIC), Salamanca., Tur L; GMV Innovating Solutions, Valencia., Dall'Olio D; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italia., Sträng E; Department of Hematology, Oncology and Cancer Immunology, Campus Virchow, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin., Tettero JM; Department of Hematology, Amsterdam University Medical Center location Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Castellani G; Department of Medical and Surgical Sciences - DIMEC, University of Bologna, Bologna., Benner A; Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg., Döhner K; Department of Internal Medicine III, University Hospital Ulm, Ulm., Thiede C; Department of Internal Medicine I, University Hospital Dresden, Dresden., Metzeler KH; Department for Hematology, Cell Therapy and Hemostaseology, University of Leipzig Medical Center, Leipzig., Haferlach T; MLL Munich Leukemia Laboratory, Munich., Damm F; Department of Hematology, Oncology and Cancer Immunology, Campus Virchow, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg., Ayala R; Hematology Department, Hospital Universitario 12 de Octubre, Complutense University CNIO Madrid., Martínez-López J; Hematology Department, Hospital Universitario 12 de Octubre, Complutense University CNIO Madrid., Mills KI; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast., Sierra J; Hospital Santa Creu Sant Pau, Barcelona., Lehmann S; Uppsala University Hospital, Uppsala., Porta MGD; IRCCS Humanitas Research Hospital, via Manzoni 56, 20089 Rozzano, Milan, Italy; and Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Milan., Mayer J; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Masaryk University., Reinhardt D; Department of Pediatrics III, University Hospital Essen, University Duisburg-Essen, Essen., Medina RV; GMV Innovating Solutions, Valencia., Schulze-Rath R; Bayer AG, Pharmaceuticals Division, Berlin., Barbus M; AbbVie Deutschland GmbH and Co KG, Wiesbaden., Hernández-Rivas JM; Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain; Hematology Department, University Hospital of Salamanca, Salamanca., Huntly BJP; Department of Haematology and Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge., Ossenkoppele G; Center, Amsterdam UMC,location VUMC, Netherlands., Döhner H; Department of Internal Medicine III, University Hospital Ulm, Ulm., Bullinger L; Department of Hematology, Oncology and Cancer Immunology, Campus Virchow, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg. lars.bullinger@charite.de.

Publikováno v: Haematologica [Haematologica] 2024 Nov 07. Date of Electronic Publication: 2024 Nov 07.

Covering Hierarchical Dirichlet Mixture Models on binary data to enhance genomic stratifications in onco-hematology.

Autor: Dall'Olio D; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italia., Sträng E; Department of Hematology, Oncology and Cancer Immunology, Campus Virchow, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Turki AT; Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany.; Department of Hematology and Oncology, Marienhospital University Hospital, Ruhr-University Bochum, Bochum, Germany., Tettero JM; Department of Hematology, Amsterdam UMC location Vrije Universiteit, Amsterdam, the Netherlands., Barbus M; AbbVie Deutschland GmbH & Co KG, Wiesbaden, Germany., Schulze-Rath R; Bayer AG, Berlin, Germany., Elicegui JM; Molecular Genetics in Oncohematology, Institute of Biomedical Research of Salamanca, Salamanca, Spain., Matteuzzi T; Department of Physics and Astronomy, University of Florence, Sesto Fiorentino, Italy., Merlotti A; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italia.; Physics and Astronomy Department, University of Bologna, Bologna, Italy., Carota L; Department of Medical and Surgical Sciences-DIMEC, University of Bologna, Bologna, Italy., Sala C; Department of Medical and Surgical Sciences-DIMEC, University of Bologna, Bologna, Italy., Della Porta MG; Comprehensive Cancer Center, IRCCS Humanitas Clinical and Research Center and Department of Biomedical Sciences, Humanitas University, Milan, Italy., Giampieri E; Department of Medical and Surgical Sciences-DIMEC, University of Bologna, Bologna, Italy., Hernández-Rivas JM; Molecular Genetics in Oncohematology, Institute of Biomedical Research of Salamanca, Salamanca, Spain.; Hematology Department, University Hospital of Salamanca, Salamanca, Spain.; Cancer Research Center of Salamanca, Salamanca, Spain., Bullinger L; Department of Hematology, Oncology and Cancer Immunology, Campus Virchow, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Castellani G; Department of Medical and Surgical Sciences-DIMEC, University of Bologna, Bologna, Italy.

Publikováno v: PLoS computational biology [PLoS Comput Biol] 2024 Feb 02; Vol. 20 (2), pp. e1011299. Date of Electronic Publication: 2024 Feb 02 (Print Publication: 2024).

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Classification and Prognostic Stratification Based on Genomic Features in Myelodysplastic and Myeloproliferative Neoplasm- and Their Overlapping Conditions.

Autor: Lee, Jong-Mi^1,2 (AUTHOR) jongmi1226@catholic.ac.kr, Lee, Ginkyeng³ (AUTHOR) gin_lee@puzzle-ai.com, Kim, Taeksang³ (AUTHOR) voidbag@gmail.com, Ahn, Ari⁴ (AUTHOR) 0124ari@catholic.ac.kr, Jung, Jin^1,2 (AUTHOR) jiinj@catholic.ac.kr, Kim, Yoo-Jin⁵ (AUTHOR) yoojink@catholic.ac.kr, Park, Silvia⁵ (AUTHOR) silvia.park@catholic.ac.kr, Kwag, Daehun⁵ (AUTHOR) kdh@catholic.ac.kr, Lee, Sung-Eun⁵ (AUTHOR) lee86@catholic.ac.kr, Park, Sung-Soo⁵ (AUTHOR) sspark@catholic.ac.kr, Kim, Tong-Yoon⁶ (AUTHOR) tyk@catholic.ac.k, Cho, Bin⁷ (AUTHOR) chobinkr@catholic.ac.kr, Chung, Nack-Gyun⁷ (AUTHOR) cngped@catholic.ac.kr, Lee, Jae Wook⁷ (AUTHOR) dashwood@catholic.ac.kr, Yoo, Jae Won⁷ (AUTHOR) hoiring0209@gmail.com, Jo, Suejung⁷ (AUTHOR) j.crystal1107@gmail.com, Kim, Yonggoo^1,2 (AUTHOR) yonggoo@catholic.ac.kr, Kim, Myungshin^1,2 (AUTHOR) microkim@catholic.ac.kr

Publikováno v: Cancers. Dec2024, Vol. 16 Issue 23, p4121. 14p.

Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype.

Autor: Wu Y; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Fletcher M; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Gu Z; Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Wang Q; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Costa B; Division of Signal Transduction and Growth Control, DKFZ/ZMBH Alliance, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Bertoni A; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Man KH; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Schlotter M; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Felsberg J; Medical Faculty, Institute of Neuropathology, Heinrich Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany.; German Cancer Consortium (DKTK), Partner site Essen/Düsseldorf, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Mangei J; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Barbus M; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Gaupel AC; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Wang W; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Weiss T; Department of Neurology and Brain Tumor Center, University Hospital Zurich, Frauenklinikstrasse 26, CH-8091, Zurich, Switzerland., Eils R; Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Weller M; Department of Neurology and Brain Tumor Center, University Hospital Zurich, Frauenklinikstrasse 26, CH-8091, Zurich, Switzerland., Liu H; Division of Molecular Neurogenetics, DKFZ-ZMBH Alliance, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Reifenberger G; Medical Faculty, Institute of Neuropathology, Heinrich Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany.; German Cancer Consortium (DKTK), Partner site Essen/Düsseldorf, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Korshunov A; Department of Neuropathology, University of Heidelberg, Im Neuenheimer Feld 220, 69120, Heidelberg, Germany.; Clinical Cooperation Unit, Neuropathology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 220-221, 69120, Heidelberg, Germany., Angel P; Division of Signal Transduction and Growth Control, DKFZ/ZMBH Alliance, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Lichter P; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; German Cancer Consortium (DKTK), Partner site Essen/Düsseldorf, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Herrmann C; Health Data Science Unit, Medical Faculty Heidelberg, Im Neuenheimer Feld 267, 69120, Heidelberg, Germany. carl.herrmann@bioquant.uni-heidelberg.de., Radlwimmer B; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. b.radlwimmer@dkfz.de.

Publikováno v: Nature communications [Nat Commun] 2020 Dec 18; Vol. 11 (1), pp. 6434. Date of Electronic Publication: 2020 Dec 18.