Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Barbra LaRue"'
Autor:
Francis J. Castellino, Barbra LaRue, Berislav V. Zlokovic, Zhihui Zhong, Rashid Deane, Abhay P. Sagare
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 29:25-33
Activated protein C (APC), a serine-protease with anticoagulant, anti-inflammatory, and cytoprotective activities, is neuroprotective and holds potential to treat different neurologic disorders. It is unknown whether APC crosses the blood—brain bar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a8c16a2a1f26edb8e8d649336b14ac
https://doi.org/10.1038/jcbfm.2008.117
https://doi.org/10.1038/jcbfm.2008.117
Autor:
Zhihui Zhong, Rashid Deane, Michael Chopp, John H. Griffin, Dong Liu, Zhang Li, Anthony L. Petraglia, Berislav V. Zlokovic, Sanjay B. Maggirwar, Meenakshisundaram Thiyagarajan, Zhenhua Wu, José A. Fernández, Tong Cheng, Barbra LaRue
Publikováno v:
Nature Medicine. 12:1278-1285
Brain hemorrhage is a serious complication of tissue plasminogen activator (tPA) therapy for ischemic stroke. Here we report that activated protein C (APC), a plasma serine protease with systemic anticoagulant, anti-inflammatory and antiapoptotic act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f540a54c277d4e1e58e36dfde393fe7
https://doi.org/10.1038/nm1498
https://doi.org/10.1038/nm1498
Autor:
Katie Hamm, Zhenhua Wu, Barbra LaRue, Margaret Parisi, Huang Guo, Berislav V. Zlokovic, Abhay P. Sagare, David M. Holtzman, Rashid Deane
Publikováno v:
The Journal of Neuroscience. 25:11495-11503
The role of blood–brain barrier (BBB) transport in clearance of amyloid β-peptide (Aβ) by Aβ immunotherapy is not fully understood. To address this issue, we studied the effects of peripherally and centrally administered Aβ-specific IgG on BBB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b7bd35bea3b99b171e8d91c4787f1d
https://doi.org/10.1523/jneurosci.3697-05.2005
https://doi.org/10.1523/jneurosci.3697-05.2005
Autor:
Suzana Jovanovic, Berislav V. Zlokovic, Calvin Maurer, Elizabeth Hogg, Rashid Deane, Barbra LaRue, Abhay P. Sagare, Lawrence M. Maness
Publikováno v:
Journal of Neuroscience Methods. 138:233-242
The role of transport exchanges of neuroactive solutes across the blood–brain barrier (BBB) is increasingly recognized. To take full advantage of genetically altered mouse models of neurodegenerative disorders for BBB transport studies, we adapted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0acaca21d73494a6ccef0f0835016d1
https://doi.org/10.1016/j.jneumeth.2004.04.026
https://doi.org/10.1016/j.jneumeth.2004.04.026
Autor:
Hong Wei Hu, Xiaomei Song, Huang Guo, Zhenhua Wu, Katie Hamm, Shi Du Yan, Barbra LaRue, Berislav V. Zlokovic, Rashid Deane, Peter J. Lenting, Feng Xu, William E. Van Nostrand, Patricia P. Spijkers, Abhay P. Sagare, Judianne Davis, Margaret Parisi
Publikováno v:
Neuron. 43(3):333-344
LRP (low-density lipoprotein receptor-related protein) is linked to Alzheimer's disease (AD). Here, we report amyloid beta-peptide Abeta40 binds to immobilized LRP clusters II and IV with high affinity (Kd = 0.6-1.2 nM) compared to Abeta42 and mutant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d35c1a9546d26333f98a6bbd971ec69
Autor:
Barbra LaRue, Nathan T. Ross, Rachal Love, Günter Fritz, Nicole Paquette, Richard J. Deane, Benjamin L. Miller, Berislav V. Zlokovic, Alan E. Friedman, Meenakshisundaram Thiyagarajan, Abhay P. Sagare, Robert D. Bell, Rashid Deane, Sheldon Perry, Troy J. Zarcone, Itender Singh
Publikováno v:
The Journal of clinical investigation. 122(4)
In Alzheimer disease (AD), amyloid β peptide (Aβ) accumulates in plaques in the brain. Receptor for advanced glycation end products (RAGE) mediates Aβ-induced perturbations in cerebral vessels, neurons, and microglia in AD. Here, we identified a h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d7eaa01e33c5f6683113782da500cb
https://pubmed.ncbi.nlm.nih.gov/22691133
https://pubmed.ncbi.nlm.nih.gov/22691133