Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Barbra H. Stewart"'
Autor:
Zhijian Zhu, O. Helen Chan, Om Prakash Goel, Huai-Gu Chen, Barbra H. Stewart, Linda A Stilgenbauer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1121-1124
In the preparation of phosphate prodrugs of PD154075, several strategies of linking a phosphate group to the indole moiety were studied. A novel linker, p-hydroxymethylbenzoyloxymethoxycarbonyl, was discovered to provide the phosphate prodrug of PD15
Publikováno v:
Pharmaceutical Research. 17:209-215
Purpose. The purpose of this study was to elucidate the mechanismsby which an HMG-CoA reductase inhibitor, atorvastatin (an organicacid with a pKa of 4.46), was transported in the secretory and absorptivedirections across Caco-2 cell monolayers.
Autor:
Hyo Kyung Han, Go Saito, Julie K. Rhie, Doo Man Oh, Barbra H. Stewart, Gordon L. Amidon, Cheng Pang Hsu
Publikováno v:
Journal of Pharmaceutical Sciences. 88:347-350
The present study characterized Chinese hamster ovary cells overexpressing a human intestinal peptide transporter, CHO/hPEPT1 cells, as an in vitro model for peptidomimetic drugs. The kinetic parameters of Gly-Sar uptake were determined in three diff
Publikováno v:
Pharmaceutical Research. 16:519-526
Purpose. The purpose of this study was to determine if the intestinal transport of pregabalin (isobutyl -γ-aminobutyric acid, isobutyl GAB A), a new anticonvulsant drug, was mediated by amino acid carriers with affinity for large neutral amino acids
Autor:
O. Helen Chan, Barbra H. Stewart
Publikováno v:
Journal of Pharmaceutical Sciences. 87:1471-1478
Publikováno v:
Life Sciences. 63:1599-1609
Endothelins are potent vasoconstrictor peptides which have a wide range of tissue distribution and three receptor subtypes (ET A , ET B and ET C ). Among the linear hexapeptide ET A /ET B receptor antagonists, PD 145065 (Ac- D -Bhg- L -Leu- L -Asp- L
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 17:851-861
An automated solid-phase extraction workstation was used to develop, characterize and validate two separate HPLC methods for quantifying drugs in plasma. Method development was facilitated by workstation functions which allowed wash solvents of varyi
Publikováno v:
Pharmaceutical Research. 15:1401-1406
Purpose. The feasibility of using hydrophobicity measurements as screens for intracellular availability in T-cells or intestinal permeability in Caco-2 cells was examined.
Autor:
Roman Herrera, Elizabeth A. Lunney, Kimberly Suzanne Para, Narayanan Surendran, James H. Fergus, Aurash Shahripour, Mark Stephen Plummer, Susan E. Hubbell, Christine Humblet, Barbra H. Stewart, Tomi K. Sawyer, Alan R. Saltiel, Charles J. Stankovic, James S. Marks
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1909-1914
Incorporation of 4-phosphonodifluoromethyl-phenylalanine (F2Pmp) and 4-phosphono-phenylalanine into SH2 targeted peptides and peptidomimetic ligands was found to effect binding affinity and selectivity of these ligands toward the Src and Abl SH2 doma
Autor:
Eric L. Reyner, Hussein Hallak, S. J. Haleen, Joseph Thomas Repine, Kathleen M. Welch, Donnelle M. Walker, Billy R. Reisdorph, M. A. Flynn, Annette Marian Doherty, Barbra H. Stewart, William C. Patt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:297-302
Continued SAR around our ETA selective series of butenolide antagonists, for example PD156707 (1) has yielded a new series of subnanomolar ETA selective antagonists. Depending upon solution pH, 1 exists as the ring closed butenolide form (shown) or a