RON is not a prognostic marker for resectable pancreatic cancer

Autor: Tactacan, Carole M, Chang, David K, Cowley, Mark J, Humphrey, Emily S, Jianmin, Wu, Gill, Anthony J, Chou, Angela, Nones, Katia, Grimmond, Sean M, Sutherland, Robert L, Biankin, Andrew V, Daly, Roger J, Biankin, Av, Johns, Al, Mawson, A, Chang, Dk, Scarlett, Cj, Brancato, Ma, Rowe, Sj, Simpson, Sl, Martyn-Smith, M, Chantrill, La, Chin, Vt, Chou, A, Cowley, Mj, Caplan, W, Humphris, Jl, Jones, Md, Mead, R, Nagrial, Am, Pajic, M, Pettit, J, Pinese, M, Rooman, I, Wu, Jun, Daly, Rj, Musgrove, Ea, Sutherland, Rl, Grimmond, Sm, Waddell, N, Kassahn, Ks, Miller, Dk, Wilson, Pj, Patch, Am, Song, S, Harliwong, I, Idrisoglu, S, Nourse, C, Nourbakhsh, E, Manning, S, Wani, S, Gongora, M, Anderson, Michela, Holmes, O, Leonard, C, Taylor, D, Wood, JOHN STEPHAN, Xu, C, Nones, K, Fink, Julika, Christ, A, Bruxner, T, Cloonan, N, Newell, F, Pearson, Jv, Samra, Js, Gill, Aj, Nickpavlakis, Guminski, A, Toon, C, Asghari, R, Merrett, Nd, Pavey, Da, Das, A, Cosman, Ph, Ismail, K, O'Connor, C, Lam, Vw, Mcleod, D, Pleass, Hc, James, V, Kench, Jg, Cooper, Cl, Joseph, D, Sandroussi, C, Crawford, M, Texler, M, Forrest, C, Laycock, A, Epari, Kp, Ballal, M, Fletcher, Dr, Mukhedkar, S, Spry, Na, Deboer, B, Chai, M, Feeney, K, Zeps, N, Beilin, M, Nguyen, Nq, Ruszkiewicz, Ar, Worthley, C, Tan, Cp, Debrencini, T, Chen, J, Brooke-Smith, Me, Papangelis, V, Tang, H, Barbour, Ap, Clouston, Ad, Martin, P, O'Rourke, Tj, Chiang, A, Fawcett, Jw, Slater, K, Yeung, S, Hatzifotis, M, Hodgkinson, P, Christophi, C, Nikfarjam, M, Eshleman, Jr, Hruban, Rh, Maitra, A, Iacobuzio-Donahue, Ca, Schulick, Rd, Wolfgang, Cl, Morgan, Ra, Scarpa, A, Lawlor, Rt, Beghelli, S, Corbo, V, Scardoni, M, Bassi, C, Tempero, Ma.

Publikováno v: BMC Cancer, Vol 12, Iss 1, p 395 (2012)
BMC Cancer

Background The receptor tyrosine kinase RON exhibits increased expression during pancreatic cancer progression and promotes migration, invasion and gemcitabine resistance of pancreatic cancer cells in experimental models. However, the prognostic sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282ade2f86adcce4d0711d5878efb69c
https://eprints.gla.ac.uk/155543/1/155543.pdf

Spatial intra-tumour heterogeneity and treatment-induced genomic evolution in oesophageal adenocarcinoma: implications for prognosis and therapy.

Autor: Brosda S; Frazer Institute, The University of Queensland, 37 Kent Street, Woolloongabba, QLD, 4102, Australia. s.brosda@uq.edu.au., Aoude LG; Frazer Institute, The University of Queensland, 37 Kent Street, Woolloongabba, QLD, 4102, Australia., Bonazzi VF; Frazer Institute, The University of Queensland, 37 Kent Street, Woolloongabba, QLD, 4102, Australia., Patel K; Frazer Institute, The University of Queensland, 37 Kent Street, Woolloongabba, QLD, 4102, Australia., Lonie JM; Frazer Institute, The University of Queensland, 37 Kent Street, Woolloongabba, QLD, 4102, Australia., Belle CJ; Frazer Institute, The University of Queensland, 37 Kent Street, Woolloongabba, QLD, 4102, Australia., Newell F; QIMR Berghofer Medical Research Institute, Herston, QLD, 4006, Australia., Koufariotis LT; QIMR Berghofer Medical Research Institute, Herston, QLD, 4006, Australia., Addala V; QIMR Berghofer Medical Research Institute, Herston, QLD, 4006, Australia., Naeini MM; QIMR Berghofer Medical Research Institute, Herston, QLD, 4006, Australia.; Garvan Institute of Medical Research, Darlinghurst, NSW, 2010, Australia.; Faculty of Medicine, St Vincent's Clinical School, University of New South Wales, Sydney, NSW, 2052, Australia., Pearson JV; QIMR Berghofer Medical Research Institute, Herston, QLD, 4006, Australia., Krause L; Frazer Institute, The University of Queensland, 37 Kent Street, Woolloongabba, QLD, 4102, Australia.; Microba Life Sciences, Brisbane, QLD, 4000, Australia., Waddell N; QIMR Berghofer Medical Research Institute, Herston, QLD, 4006, Australia., Barbour AP; Frazer Institute, The University of Queensland, 37 Kent Street, Woolloongabba, QLD, 4102, Australia.; Princess Alexandra Hospital, Woolloongabba, QLD, 4102, Australia.

Publikováno v: Genome medicine [Genome Med] 2024 Jul 17; Vol. 16 (1), pp. 90. Date of Electronic Publication: 2024 Jul 17.

The oesophageal adenocarcinoma tumour immune microenvironment dictates outcomes with different modalities of neoadjuvant therapy - results from the AGITG DOCTOR trial and the cancer evolution biobank.

Autor: Lonie JM; Surgical Oncology Group, Frazer Institute, The University of Queensland, Brisbane, QLD, Australia., Brosda S; Surgical Oncology Group, Frazer Institute, The University of Queensland, Brisbane, QLD, Australia., Bonazzi VF; Surgical Oncology Group, Frazer Institute, The University of Queensland, Brisbane, QLD, Australia., Aoude LG; Surgical Oncology Group, Frazer Institute, The University of Queensland, Brisbane, QLD, Australia., Patel K; Surgical Oncology Group, Frazer Institute, The University of Queensland, Brisbane, QLD, Australia., Brown I; Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.; Envoi Specialist Pathologists, Brisbane, QLD, Australia.; Department of Pathology, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia., Sharma S; Medlab Pathology, Sydney, NSW, Australia.; Medical Genomics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Lampe G; Department of Anatomical Pathology, Central Laboratory Pathology Queensland, Brisbane, QLD, Australia., Addala V; Medical Genomics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Koufariotis LT; Medical Genomics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Wood S; Medical Genomics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Waddell N; Medical Genomics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Dolcetti R; Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.; Translational and Clinical Immunotherapy, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia.; Department of Microbiology and Immunology, The University of Melbourne, Melbourne, VIC, Australia., Barbour AP; Surgical Oncology Group, Frazer Institute, The University of Queensland, Brisbane, QLD, Australia.; Department of Surgery, Princess Alexandra Hospital, Brisbane, QLD, Australia.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Oct 12; Vol. 14, pp. 1220129. Date of Electronic Publication: 2023 Oct 12 (Print Publication: 2023).

C-reactive protein is a prognostic biomarker in pancreatic ductal adenocarcinoma patients.

Autor: Bonazzi VF; Frazer Institute, The University of Queensland, Woolloongabba, Queensland, Australia., Aoude LG; Frazer Institute, The University of Queensland, Woolloongabba, Queensland, Australia., Brosda S; Frazer Institute, The University of Queensland, Woolloongabba, Queensland, Australia., Bradford JJ; Frazer Institute, The University of Queensland, Woolloongabba, Queensland, Australia., Lonie JM; Frazer Institute, The University of Queensland, Woolloongabba, Queensland, Australia., Loffler KA; Frazer Institute, The University of Queensland, Woolloongabba, Queensland, Australia.; College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia., Gartside MG; Frazer Institute, The University of Queensland, Woolloongabba, Queensland, Australia., Patel K; Frazer Institute, The University of Queensland, Woolloongabba, Queensland, Australia., Mukhopadhyay P; QIMR, Berghofer Medical Research Institute, Herston, Queensland, Australia., Keane C; Mater Research Institute-UQ, South Brisbane, Queensland, Australia., Gebski V; NHMRC Clinical Trials Centre, Camperdown, New South Wales, Australia., Kench JG; Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.; University of Sydney Central Clinical School, Camperdown, New South Wales, Australia., Goldstein D; University of NSW Prince of Wales Clinical School, Randwick, New South Wales, Australia., Waddell N; QIMR, Berghofer Medical Research Institute, Herston, Queensland, Australia., Barbour AP; Frazer Institute, The University of Queensland, Woolloongabba, Queensland, Australia.; Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.

Publikováno v: Asia-Pacific journal of clinical oncology [Asia Pac J Clin Oncol] 2023 Jul 06. Date of Electronic Publication: 2023 Jul 06.

Heritable defects in telomere and mitotic function selectively predispose to sarcomas.

Autor: Ballinger ML; Garvan Institute of Medical Research, Sydney 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney 2010, Australia., Pattnaik S; Garvan Institute of Medical Research, Sydney 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney 2010, Australia., Mundra PA; Garvan Institute of Medical Research, Sydney 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney 2010, Australia., Zaheed M; Hereditary Cancer Centre, Prince of Wales Hospital, Sydney 2031, Australia., Rath E; Garvan Institute of Medical Research, Sydney 2010, Australia., Priestley P; Hartwig Medical Foundation, 1098 XH Amsterdam, Netherlands.; Hartwig Medical Foundation Australia, Sydney 2000, Australia., Baber J; Hartwig Medical Foundation, 1098 XH Amsterdam, Netherlands.; Hartwig Medical Foundation Australia, Sydney 2000, Australia., Ray-Coquard I; Department of Adult Medical Oncology, Centre Leon Berard, University Claude Bernard, 69373 Lyon, France., Isambert N; Centre Georges Francois Leclerc, 21000 Dijon, France., Causeret S; Centre Georges Francois Leclerc, 21000 Dijon, France., van der Graaf WTA; Sarcoma Unit, The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK., Puri A; Department of Orthopedic Oncology, Tata Memorial Hospital, Mumbai, Maharashtra 400012, India., Duffaud F; la Timone University Hospital, 13005 Marseille, France., Le Cesne A; Gustave Roussy, 94805 Villejuif, France., Seddon B; Sarcoma Unit, University College Hospital, London NW1 2BU, UK., Chandrasekar C; Liverpool University Hospitals NHS Foundation Trust, Liverpool L7 8XP, UK., Schiffman JD; Division of Pediatric Hematology/Oncology, Department of Pediatrics, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA., Brohl AS; Sarcoma Department, Moffitt Cancer Center, Tampa, FL 33612, USA., James PA; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne 3010, Australia.; Parkville Familial Cancer Centre, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne 3000, Australia., Kurtz JE; Centre Hospitalier Universitaire Hautepierre, 67200 Strasbourg, France., Penel N; Centre Oscar Lambret, 59000 Lille, France., Myklebost O; Western Norway Familial Cancer Centre, Haukeland University Hospital, 5021 Bergen, Norway.; Department of Clinical Science, University of Bergen, 5007 Bergen, Norway.; Institute for Cancer Research, Oslo University Hospital, N-0424 Oslo, Norway., Meza-Zepeda LA; Institute for Cancer Research, Oslo University Hospital, N-0424 Oslo, Norway., Pickett H; Children's Medical Research Institute, The University of Sydney, Westmead 2145, Australia., Kansara M; Garvan Institute of Medical Research, Sydney 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney 2010, Australia., Waddell N; QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia., Kondrashova O; QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia., Pearson JV; QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia., Barbour AP; Faculty of Medicine. The University of Queensland, Brisbane 4072, Australia., Li S; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne 3010, Australia.; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton 3800, Australia.; Murdoch Children's Research Institute, Royal Children's Hospital, Parkville 3051, Australia., Nguyen TL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne 3010, Australia., Fatkin D; St Vincent's Clinical School, University of New South Wales, Sydney 2010, Australia.; Molecular Cardiology Division, Victor Chang Cardiac Research Institute, Darlinghurst 2010, Australia.; Cardiology Department, St Vincent's Hospital, Sydney 2010, Australia., Graham RM; St Vincent's Clinical School, University of New South Wales, Sydney 2010, Australia.; Molecular Cardiology Division, Victor Chang Cardiac Research Institute, Darlinghurst 2010, Australia., Giannoulatou E; St Vincent's Clinical School, University of New South Wales, Sydney 2010, Australia.; Computational Genomics Division, Victor Chang Cardiac Research Institute, Sydney 2010, Australia., Green MJ; School of Psychiatry, University of New South Wales, Sydney 2052, Australia.; Neuorscience Research Australia, Sydney 2031, Australia., Kaplan W; Garvan Institute of Medical Research, Sydney 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney 2010, Australia., Ravishankar S; Garvan Institute of Medical Research, Sydney 2010, Australia., Copty J; Garvan Institute of Medical Research, Sydney 2010, Australia., Powell JE; Garvan Institute of Medical Research, Sydney 2010, Australia.; UNSW Cellular Genomics Futures Institute, University of New South Wales, Sydney 2052, Australia., Cuppen E; Hartwig Medical Foundation, 1098 XH Amsterdam, Netherlands., van Eijk K; Department of Neurology, University Medical Centre Utrecht Brain Center, Utrecht University, 3584 CX Utrecht, Netherlands., Veldink J; Department of Neurology, University Medical Centre Utrecht Brain Center, Utrecht University, 3584 CX Utrecht, Netherlands., Ahn JH; Department of Oncology, Asan Medical Centre, Seoul 05505, South Korea., Kim JE; Department of Oncology, Asan Medical Centre, Seoul 05505, South Korea., Randall RL; Department of Orthopaedic Surgery, University of California, Davis Health, Sacramento, CA 95817, USA., Tucker K; Hereditary Cancer Centre, Prince of Wales Hospital, Sydney 2031, Australia., Judson I; Sarcoma Unit, The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK., Sarin R; Cancer Genetics Unit, ACTREC, Tata Memorial Centre, Mumbai, Maharashtra 410210, India., Ludwig T; Université de Brest, Inserm, EFS, UMR 1078, GGB, CHU de Brest, 29200 Brest, France., Genin E; Université de Brest, Inserm, EFS, UMR 1078, GGB, CHU de Brest, 29200 Brest, France., Deleuze JF; Centre National de Recherche en Génomique Humaine, Institut de Génomique, 91057 Evry, France., Haber M; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Kensington 2033, Australia., Marshall G; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Kensington 2033, Australia.; Kids Cancer Centre, Sydney Children's Hospital, Randwick 2031, Australia., Cairns MJ; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan 2308, Australia.; Centre for Brain and Mental Health Research, The Hunter Medical Research Institute, Newcastle 2305, Australia., Blay JY; Department of Adult Medical Oncology, Centre Leon Berard, University Claude Bernard, 69373 Lyon, France., Thomas DM; Garvan Institute of Medical Research, Sydney 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney 2010, Australia., Tattersall M, Neuhaus S, Lewis C, Tucker K, Carey-Smith R, Wood D, Porceddu S, Dickinson I, Thorne H, James P, Ray-Coquard I, Blay JY, Cassier P, Le Cesne A, Duffaud F, Penel N, Isambert N, Kurtz JE, Puri A, Sarin R, Ahn JH, Kim JE, Ward I, Judson I, van der Graaf W, Seddon B, Chandrasekar C, Rickar R, Hennig I, Schiffman J, Randall RL, Silvestri A, Zaratzian A, Tayao M, Walwyn K, Niedermayr E, Mang D, Clark R, Thorpe T, MacDonald J, Riddell K, Mar J, Fennelly V, Wicht A, Zielony B, Galligan E, Glavich G, Stoeckert J, Williams L, Djandjgava L, Buettner I, Osinki C, Stephens S, Rogasik M, Bouclier L, Girodet M, Charreton A, Fayet Y, Crasto S, Sandupatla B, Yoon Y, Je N, Thompson L, Fowler T, Johnson B, Petrikova G, Hambridge T, Hutchins A, Bottero D, Scanlon D, Stokes-Denson J, Génin E, Campion D, Dartigues JF, Deleuze JF, Lambert JC, Redon R, Ludwig T, Grenier-Boley B, Letort S, Lindenbaum P, Meyer V, Quenez O, Dina C, Bellenguez C, Le Clézio CC, Giemza J, Chatel S, Férec C, Le Marec H, Letenneur L, Nicolas G, Rouault K

Publikováno v: Science (New York, N.Y.) [Science] 2023 Jan 20; Vol. 379 (6629), pp. 253-260. Date of Electronic Publication: 2023 Jan 19.