La Sarcolipine, un régulateur de l'ATPase-Ca2+ SERCA1a : études in silico

Autor: Barbot, Thomas

La Sarcolipine (SLN) est un hélice transmembranaire de 31 résidus dont la function est de reguler l’ATPase-Ca2+ SERCA1a. Ce régulateur peut subir une modification post-traductionnelle chez certaines espèces. Par exemple, chez le lapin, il est p

Externí odkaz: http://www.theses.fr/2018SACLS130/document

Sarcolipin alters SERCA1a interdomain communication by impairing binding of both calcium and ATP

Autor: Montigny, Cédric, Huang, Dong Liang, Beswick, Veronica, Barbot, Thomas, Jaxel, Christine, le Maire, Marc, Zheng, Ji-Shen, Jamin, Nadège

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2021, 11 (1), pp.1641. ⟨10.1038/s41598-021-81061-6⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports, 2021, 11 (1), pp.1641. ⟨10.1038/s41598-021-81061-6⟩

Number: 1 Publisher: Nature Publishing Group; International audience; Sarcolipin (SLN), a single-spanning membrane protein, is a regulator of the sarco-endoplasmic reticulum Ca$^{2+}$-ATPase (SERCA1a). Chemically synthesized SLN, palmitoylated or not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::57e4d74b80b97ae1724adf96a0d2aeb2
https://hal.archives-ouvertes.fr/hal-03129096/document

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Sarcolipin alters SERCA1a interdomain communication by impairing binding of both calcium and ATP.

Autor: Montigny C; CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, 91198, Gif-sur-Yvette, France. cedric.montigny@i2bc.paris-saclay.fr., Huang DL; Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China., Beswick V; CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, 91198, Gif-sur-Yvette, France.; Department of Physics, Evry-Val-d'Essonne University, 91025, Evry, France., Barbot T; CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, 91198, Gif-sur-Yvette, France., Jaxel C; CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, 91198, Gif-sur-Yvette, France., le Maire M; CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, 91198, Gif-sur-Yvette, France., Zheng JS; Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China. jszheng@ustc.edu.cn., Jamin N; CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, 91198, Gif-sur-Yvette, France.

Publikováno v: Scientific reports [Sci Rep] 2021 Jan 15; Vol. 11 (1), pp. 1641. Date of Electronic Publication: 2021 Jan 15.