Mucus concentration-dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis.

Autor: Kato T; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Respiratory Medicine, University of Tokyo, Tokyo, Japan., Radicioni G; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Papanikolas MJ; Department of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Stoychev GV; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Markovetz MR; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Aoki K; Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA., Porterfield M; Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA., Okuda K; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Barbosa Cardenas SM; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Gilmore RC; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Morrison CB; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Ehre C; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Burns KA; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., White KK; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Brennan TA; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Goodell HP; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Thacker H; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Loznev HT; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Forsberg LJ; Protein Expression and Purification Core, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Nagase T; Department of Respiratory Medicine, University of Tokyo, Tokyo, Japan., Rubinstein M; Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA., Randell SH; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Tiemeyer M; Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA., Hill DB; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Kesimer M; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., O'Neal WK; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Ballard ST; Department of Physiology and Cell Biology, University of South Alabama, Mobile, AL, USA., Freeman R; Department of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Button B; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Boucher RC; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Publikováno v: Science advances [Sci Adv] 2022 Apr; Vol. 8 (13), pp. eabm9718. Date of Electronic Publication: 2022 Apr 01.