Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Barbora Vyhlidalova"'
Autor:
Karolína Ondrová, Iveta Zůvalová, Barbora Vyhlídalová, Kristýna Krasulová, Eva Miková, Radim Vrzal, Petr Nádvorník, Binod Nepal, Sandhya Kortagere, Martina Kopečná, David Kopečný, Marek Šebela, Fraydoon Rastinejad, Hua Pu, Miroslav Soural, Katharina Maria Rolfes, Thomas Haarmann-Stemmann, Hao Li, Sridhar Mani, Zdeněk Dvořák
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The human aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is a pivotal regulator of human physiology and pathophysiology. Allosteric inhibition of AhR was previously thought to be untenable. Here, we identify
Externí odkaz:
https://doaj.org/article/269654521e354a11b792e6976398f868
Autor:
Sridhar Mani, Karolina Poulikova, Saraswathi Vishveshwara, Satyanarayana R. Pondugula, Zdenek Dvorak, Kodye L. Abbott, Eva Jiskrova, Barbora Vyhlidalova, Aneesh Chandran, Chloe S. Chaudhury
Publikováno v:
Molecular Pharmacology. 95:324-334
Activation of human pregnane X receptor (hPXR) has been associated with induction of chemoresistance. It has been proposed that such chemoresistance via cytochrome P450/drug transporters can be reversed with the use of antagonists that specifically a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500f02543079469970892c230ee54976
https://doi.org/10.1124/mol.118.114587
https://doi.org/10.1124/mol.118.114587
Autor:
Zdeněk Dvořák, Felix Kopp, Cait M Costello, Jazmin S Kemp, Hao Li, Aneta Vrzalová, Martina Štěpánková, Iveta Bartoňková, Eva Jiskrová, Karolína Poulíková, Barbora Vyhlídalová, Lars U Nordstroem, Chamini V Karunaratne, Harmit S Ranhotra, Kyu Shik Mun, Anjaparavanda P Naren, Iain A Murray, Gary H Perdew, Julius Brtko, Lucia Toporova, Arne Schön, Bret D Wallace, William G Walton, Matthew R Redinbo, Katherine Sun, Amanda Beck, Sandhya Kortagere, Michelle C Neary, Aneesh Chandran, Saraswathi Vishveshwara, Maria M Cavalluzzi, Giovanni Lentini, Julia Yue Cui, Haiwei Gu, John C March, Shirshendu Chatterjee, Adam Matson, Dennis Wright, Kyle L Flannigan, Simon A Hirota, Ryan Balfour Sartor, Sridhar Mani
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 4, Pp 1-19 (2020)
Abstract The human PXR (pregnane X receptor), a master regulator of drug metabolism, has essential roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have substantial off‐target toxicity. Based on prior work that esta
Externí odkaz:
https://doaj.org/article/3bc1d75f8f9149f2b831e9fe3ca8d3bb