Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Barbora Valcikova"'
Autor:
Pavlína Kosztyu, Iva Slaninová, Barbora Valčíková, Amandine Verlande, Petr Müller, Jan J. Paleček, Stjepan Uldrijan
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Mdm2 and MdmX are related proteins serving in the form of the Mdm2 homodimer or Mdm2/MdmX heterodimer as an E3 ubiquitin ligase for the tumor suppressor p53. The dimerization is required for the E3 activity and is mediated by the conserved RING domai
Externí odkaz:
https://doaj.org/article/8d7027099b474166bebd2289da2b02c5
Autor:
Georgios Valianatos, Barbora Valcikova, Katerina Growkova, Amandine Verlande, Jitka Mlcochova, Lenka Radova, Monika Stetkova, Michaela Vyhnakova, Ondrej Slaby, Stjepan Uldrijan
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185801 (2017)
MdmX overexpression contributes to the development of cancer by inhibiting tumor suppressor p53. A switch in the alternative splicing of MdmX transcript, leading to the inclusion of exon 6, has been identified as the primary mechanism responsible for
Externí odkaz:
https://doaj.org/article/388e2b6385c949e7a4f75a34a9d44a06