Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Barbora Valčíková"'
Autor:
Pavlína Kosztyu, Iva Slaninová, Barbora Valčíková, Amandine Verlande, Petr Müller, Jan J. Paleček, Stjepan Uldrijan
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Mdm2 and MdmX are related proteins serving in the form of the Mdm2 homodimer or Mdm2/MdmX heterodimer as an E3 ubiquitin ligase for the tumor suppressor p53. The dimerization is required for the E3 activity and is mediated by the conserved RING domai
Externí odkaz:
https://doaj.org/article/8d7027099b474166bebd2289da2b02c5
Autor:
Herbert Waldmann, Jana Flegel, Slava Ziegler, Barbora Valčíková, Stjepan Uldrijan, Sonja Sievers, Michaela Hylsová, Apirat Chaikuad, Stefan Knapp, Benedict-Tilman Berger, Lukáš Maier, Martin Schröder, Vaclav Nemec, Karel Souček, Stanislav Drápela, Kamil Paruch
Publikováno v:
Angewandte Chemie International Edition. 58:1062-1066
Reported is the identification of the furo[3,2-b]pyridine core as a novel scaffold for potent and highly selective inhibitors of cdc-like kinases (CLKs) and efficient modulators of the Hedgehog signaling pathway. Initially, a diverse target compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bceadfff059ca612ae335cd672c7a8a
https://doi.org/10.1002/anie.201810312
https://doi.org/10.1002/anie.201810312
Autor:
Panagiotis Alexiou, Monika Štětková, Kateřina Growková, Veronika Palušová, Vladimír Rotrekl, Barbora Valčíková, Amandine Verlande, Petr Fojtík, Vladimír Kryštof, Stjepan Uldrijan, Radek Jorda, Václav Hejret
Publikováno v:
Cell Death and Disease, Vol 11, Iss 9, Pp 1-14 (2020)
Cell Death & Disease
Cell Death & Disease
The identification of the essential role of cyclin-dependent kinases (CDKs) in the control of cell division has prompted the development of small-molecule CDK inhibitors as anticancer drugs. For many of these compounds, the precise mechanism of actio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9496955d4cd1493e310b028fabe55c7c
https://doi.org/10.1038/s41419-020-02971-3
https://doi.org/10.1038/s41419-020-02971-3
Autor:
Monika Stetkova, Michaela Vyhnakova, Barbora Valčíková, Jitka Mlčochová, Amandine Verlande, Lenka Radová, Ondrej Slaby, Stjepan Uldrijan, Katerina Growkova, Georgios Valianatos
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 10, p e0185801 (2017)
PLoS ONE, Vol 12, Iss 10, p e0185801 (2017)
MdmX overexpression contributes to the development of cancer by inhibiting tumor suppressor p53. A switch in the alternative splicing of MdmX transcript, leading to the inclusion of exon 6, has been identified as the primary mechanism responsible for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d03d1da9b9b9fa250d9e0bd23cfc8a
http://europepmc.org/articles/PMC5626491
http://europepmc.org/articles/PMC5626491
Autor:
Julien Douet, Caterina Fusilli, Matthias Van Haele, Stjepan Uldrijan, Marcus Buschbeck, Oriana Lo Re, Barbora Valčíková, Manlio Vinciguerra, Francesca Rappa, Illar Pata, Tommaso Mazza, Tania Roskams, Sura Wanessa Santos Rocha, Jana Pindjakova, Raymond S. Yeung, Christina Alves Peixoto
Publikováno v:
Hepatology (Baltimore, Md.). 67(2)
Hepatocellular carcinomas (HCC) contain a subpopulation of cancer stem cells (CSCs), which exhibit stem cellâlike features and are responsible for tumor relapse, metastasis, and chemoresistance. The development of effective treatments for HCC wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74fef1a7a30fd97dc2f12a58710e80a5
https://pubmed.ncbi.nlm.nih.gov/28913935
https://pubmed.ncbi.nlm.nih.gov/28913935
Autor:
Georgios Valianatos, Barbora Valcikova, Katerina Growkova, Amandine Verlande, Jitka Mlcochova, Lenka Radova, Monika Stetkova, Michaela Vyhnakova, Ondrej Slaby, Stjepan Uldrijan
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185801 (2017)
MdmX overexpression contributes to the development of cancer by inhibiting tumor suppressor p53. A switch in the alternative splicing of MdmX transcript, leading to the inclusion of exon 6, has been identified as the primary mechanism responsible for
Externí odkaz:
https://doaj.org/article/388e2b6385c949e7a4f75a34a9d44a06