Výsledky vyhledávání - "Barbora Malecova"

Akademický článek

Dynamics of cellular states of fibro-adipogenic progenitors during myogenesis and muscular dystrophy

Autor: Barbora Malecova, Sole Gatto, Usue Etxaniz, Magda Passafaro, Amy Cortez, Chiara Nicoletti, Lorenzo Giordani, Alessio Torcinaro, Marco De Bardi, Silvio Bicciato, Francesca De Santa, Luca Madaro, Pier Lorenzo Puri

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Fibro-adipogenic progenitors (FAPs) resident in skeletal muscle are involved in both regeneration and maladaptive processes. Here, the authors identify subpopulations of FAPs with biological activities implicated in physiological muscle repair that a

Externí odkaz: https://doaj.org/article/a4ca33e25f2e4918b9bcaecc28dae436

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Targeted tissue delivery of RNA therapeutics using antibody–oligonucleotide conjugates (AOCs)

Autor: Barbora Malecova, Rob S Burke, Michael Cochran, Michael D Hood, Rachel Johns, Philip R Kovach, Venkata R Doppalapudi, Gulin Erdogan, J Danny Arias, Beatrice Darimont, Christopher D Miller, Hanhua Huang, Andrew Geall, Husam S Younis, Arthur A Levin

Publikováno v: Nucleic Acids Research.

Although targeting TfR1 to deliver oligonucleotides to skeletal muscle has been demonstrated in rodents, effectiveness and pharmacokinetic/pharmacodynamic (PKPD) properties remained unknown in higher species. We developed antibody–oligonucleotide c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e257c1cb5d93c7540c6e8125093ab60d
https://doi.org/10.1093/nar/gkad415

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Akademický článek

Muscle-relevant genes marked by stable H3K4me2/3 profiles and enriched MyoD binding during myogenic differentiation.

Autor: Huanhuan Cui, Vikas Bansal, Marcel Grunert, Barbora Malecova, Alessandra Dall'Agnese, Lucia Latella, Sole Gatto, Tammy Ryan, Kerstin Schulz, Wei Chen, Cornelia Dorn, Pier Lorenzo Puri, Silke R Sperling

Publikováno v: PLoS ONE, Vol 12, Iss 6, p e0179464 (2017)

Post-translational modifications of histones play a key role in the regulation of gene expression during development and differentiation. Numerous studies have shown the dynamics of combinatorial regulation by transcription factors and histone modifi

Externí odkaz: https://doaj.org/article/f32d63eabccb4d259cc60d9c53e249b9

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Akademický článek

Epigenetic Reprogramming of Human Embryonic Stem Cells into Skeletal Muscle Cells and Generation of Contractile Myospheres

Autor: Sonia Albini, Paula Coutinho, Barbora Malecova, Lorenzo Giordani, Alex Savchenko, Sonia Vanina Forcales, Pier Lorenzo Puri

Publikováno v: Cell Reports, Vol 3, Iss 3, Pp 661-670 (2013)

Direct generation of a homogeneous population of skeletal myoblasts from human embryonic stem cells (hESCs) and formation of three-dimensional contractile structures for disease modeling in vitro are current challenges in regenerative medicine. Previ

Externí odkaz: https://doaj.org/article/1a08573400e94c8bb31245094c338b91

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Akademický článek

TBP/TFIID-dependent activation of MyoD target genes in skeletal muscle cells

Autor: Barbora Malecova, Alessandra Dall'Agnese, Luca Madaro, Sole Gatto, Paula Coutinho Toto, Sonia Albini, Tammy Ryan, Làszlò Tora, Pier Lorenzo Puri

Publikováno v: eLife, Vol 5 (2016)

Change in the identity of the components of the transcription pre-initiation complex is proposed to control cell type-specific gene expression. Replacement of the canonical TFIID-TBP complex with TRF3/TBP2 was reported to be required for activation o

Externí odkaz: https://doaj.org/article/cc4c05f27354405b9bad96eec246992b

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Dynamics of cellular states of fibro-adipogenic progenitors during myogenesis and muscular dystrophy

Autor: Amy Cortez, Chiara Nicoletti, Silvio Bicciato, Lorenzo Giordani, Usue Etxaniz, Luca Madaro, Marco De Bardi, Pier Lorenzo Puri, Barbora Malecova, Alessio Torcinaro, Magda Passafaro, Sole Gatto, Francesca De Santa

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications

Fibro-adipogenic progenitors (FAPs) are currently defined by their anatomical position, expression of non-specific membrane-associated proteins, and ability to adopt multiple lineages in vitro. Gene expression analysis at single-cell level reveals th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c45feb352ca1915a6e127caa5e2f8d5
http://hdl.handle.net/11573/1191021

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Taspase1 processing alters TFIIA cofactor properties in the regulation of TFIID

Autor: Diane Frances Lee, Thomas Oelgeschläger, James J. Hsieh, Valentina S Caputo, Barbora Malecova

Publikováno v: Transcription. 6:21-32

TFIIA is an important positive regulator of TFIID, the primary promoter recognition factor of the basal RNA polymerase II transcription machinery. TFIIA antagonises negative TFIID regulators such as negative cofactor 2 (NC2), promotes specific bindin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afebceb831b6d242247bd81b5369c1b7
https://doi.org/10.1080/21541264.2015.1052178

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Single Cell Gene Expression Profiling of Skeletal Muscle-Derived Cells

Autor: Sole, Gatto, Pier Lorenzo, Puri, Barbora, Malecova

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1556

Single cell gene expression profiling is a fundamental tool for studying the heterogeneity of a cell population by addressing the phenotypic and functional characteristics of each cell. Technological advances that have coupled microfluidic technologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::155a6b2397678bfa411024e020a0693f
https://pubmed.ncbi.nlm.nih.gov/28247351

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