Výsledky vyhledávání - "Barbora Dvorakova"

Akademický článek

Evaluation of miRNA detection methods for the analytical characteristic necessary for clinical utilization

Autor: Iveta Krepelkova, Tereza Mrackova, Jana Izakova, Barbora Dvorakova, Lenka Chalupova, Robert Mikulik, Ondrej Slaby, Milan Bartos, Viktor Ruzicka

Publikováno v: BioTechniques, Vol 66, Iss 6, Pp 277-284 (2019)

miRNAs are promising biomarkers but methods for their measurement are not clear. We therefore examined three miRNA detection technologies and considered the analytical characteristics essential for clinical utilization. TaqMan assays, SplintR-qPCR an

Externí odkaz: https://doaj.org/article/1049580bdc60438bb2bbcf594b3bf65e

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Evaluation of miRNA detection methods for the analytical characteristics necessary for clinical utilization

Autor: Milan Bartos, Robert Mikulik, Tereza Mrackova, Lenka Chalupova, Jana Izakova, Ondrej Slaby, Iveta Krepelkova, Barbora Dvorakova, Viktor Ruzicka

Publikováno v: Biotechniques
BioTechniques

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5266dd6835d35d6bc2a1eea47c847f26
https://is.muni.cz/publication/1590516

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Abstract LB-388: New clinical diagnostic approach for miRNA quantification using the Chlorella virus DNA ligase

Autor: Tereza Mrackova, Milan Bartos, Zlata Stastna, Michaela Adamcova, Ondrej Slaby, Barbora Dvorakova, Viktor Ruzicka, Iveta Hynstova

Publikováno v: Cancer Research. 78:LB-388

miRNAs have an immense potential to serve as diagnostic, prognostic and prediction biomarkers in the whole field of oncology. Their utilization in liquid biopsy as a non-invasive diagnostic tool is very promising as well. However, to our knowledge, n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b6bc899e96883b8559a9ab4b924c5cf
https://doi.org/10.1158/1538-7445.am2018-lb-388

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Chimera of IL-2 Linked to Light Chain of anti-IL-2 mAb Mimics IL-2/anti-IL-2 mAb Complexes Both Structurally and Functionally

Autor: Marek Kovar, Barbora Dvorakova, Petra Votavova, Helena Chmelova, Jakub Tomala, Martina Kabesova, Jirina Kovarova, Blanka Rihova

Publikováno v: ACS Chemical Biology. 8:871-876

IL-2/anti-IL-2 mAb immunocomplexes were described to have dramatically higher activity than free IL-2 in vivo. We designed protein chimera consisting of IL-2 linked to light chain of anti-IL-2 mAb S4B6 through flexible oligopeptide spacer (Gly(4)Ser)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce43377d59f9644dc2409a30ae9819f
https://doi.org/10.1021/cb3007242

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Activation of the Interleukin-6/STAT3 Antiapoptotic Pathway in Esophageal Cells by Bile Acids and Low pH: Relevance to Barrett's Esophagus

Autor: Katerina Dvorak, Sylvan B. Green, Lois Ramsey, Richard E. Sampliner, Harinder S. Garewal, Harris Bernstein, Barbora Dvorakova, Anil Prasad, Bohuslav Dvorak, Melissa Chavarria, Hana Holubec, Cara L. Crowley-Weber, Claire M. Payne, Carol Bernstein

Publikováno v: Clinical Cancer Research. 13:5305-5313

Objectives: The molecular factors contributing to the development of Barrett's esophagus (BE) are unclear. Our previous studies showed that BE tissues secrete interleukin-6 (IL-6) and express proteins associated with IL-6 signaling, including IL-6 re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40409f5f7a5eb3c7c6eaff8ef339540f
https://doi.org/10.1158/1078-0432.ccr-07-0483

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Bile acids in combination with low pH induce oxidative stress and oxidative DNA damage: relevance to the pathogenesis of Barrett's oesophagus

Autor: Katerina Dvorak, Naihsuan C. Guy, Melissa Chavarria, Sylvan B. Green, Richard E. Sampliner, Carol Bernstein, Harinder S. Garewal, Lois Ramsey, Harris Bernstein, Barbora Dvorakova, Claire M. Payne, Amanda Condon, Hana Holubec, Anil Prasad

Publikováno v: Gut. 56:763-771

Background: Barrett’s oesophagus is a premalignant condition associated with an increased risk for the development of oesophageal adenocarcinoma (ADCA). Previous studies indicated that oxidative damage contributes to the development of ADCA. Object

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635792183b87d68e045a6d2047922277
https://doi.org/10.1136/gut.2006.103697

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ChemInform Abstract: The Preparation of Various New Heterocyclic Compounds via Cyclization of Substituted Derivatives of Phenacyl Esters of Hydrazonoacetic Acid

Autor: Barbora Dvorakova, Antonín Lyčka, Radek Melnicky, Pavel Hradil, Martin Grepl, Lubomir Kvapil, Valerio Bertolasi

Publikováno v: ChemInform. 45

The acid-mediated Fischer-indole synthesis type cyclization of hydrazones (I) and (V) is studied resulting in the formation of indoles (II) and (VI).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6415415571dd0d437c913570af10706a
https://doi.org/10.1002/chin.201406135

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Esophageal acid exposure at pHor = 2 is more common in Barrett's esophagus patients and is associated with oxidative stress

Autor: Harris Bernstein, Harinder S. Garewal, M. Chavarria, Katerina Dvorak, Barbora Dvorakova, Carol Bernstein, Ronnie Fass, Claire M. Payne, R. Dekel

Publikováno v: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. 19(5)

Barrett's esophagus (BE) patients demonstrate a higher distal esophageal acid exposure profile than other gastroesophageal reflux disease patients. Cellular oxidative stress has been proposed to contribute to the development of BE and esophageal aden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86b4cdab7d70008d553d133457177d1
https://pubmed.ncbi.nlm.nih.gov/16984534

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Deoxycholate-induced colitis is markedly attenuated in Nos2 knockout mice in association with modulation of gene expression profiles

Autor: Eugene W. Gerner, Katerina Dvorak, Claire M. Payne, Harris Bernstein, Hana Holubec, Jose L. Padilla-Torres, David G. Besselsen, Natalia A. Ignatenko, Karen A. Blohm-Mangone, Carol Bernstein, Barbora Dvorakova, Harinder S. Garewal

Publikováno v: Digestive diseases and sciences. 52(3)

Nos2 knockout mice were compared to wild-type mice for susceptibility to colitis in response to a diet supplemented with deoxycholate, a bile acid increased in the colon of individuals on a high-fat diet. Wild-type mice fed a fat-related diet, supple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a068bbe34f3dbc5479d969b1853947fb
https://pubmed.ncbi.nlm.nih.gov/17253130

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Crypt-restricted loss and decreased protein expression of cytochrome C oxidase subunit I as potential hypothesis-driven biomarkers of colon cancer risk

Autor: Harris Bernstein, Katerina Dvorak, Claire M. Payne, Megan Wilson, Hana Holubec, Monique Dall'Agnol, James Warneke, Harinder S. Garewal, Carol Bernstein, Barbora Dvorakova, Sylvan B. Green

Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 14(9)

There is an increasing demand for the development of intermediate biomarkers to assess colon cancer risk. We previously determined that a live cell bioassay, which assesses apoptosis resistance in the nonneoplastic colonic mucosa, detects ∼50% of p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a55adf42f68e0bd144539ea23f302bbb
https://pubmed.ncbi.nlm.nih.gov/16172211

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