trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo.

Autor: Aron ZD; Microbiotix, Inc. One Innovation Dr., Worcester, MA, USA., Mehrani A; Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL, USA., Hoffer ED; Department of Biochemistry and Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, GA, USA., Connolly KL; Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA., Srinivas P; Department of Biochemistry and Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, GA, USA.; Molecular & Systems Pharmacology Graduate Program, Emory University, Atlanta, GA, USA., Torhan MC; Microbiotix, Inc. One Innovation Dr., Worcester, MA, USA., Alumasa JN; Department of Biochemistry & Molecular Biology, Penn State University, University Park, PA, USA., Cabrera M; Department of Biochemistry & Molecular Biology, Penn State University, University Park, PA, USA., Hosangadi D; Department of Biochemistry & Molecular Biology, Penn State University, University Park, PA, USA., Barbor JS; Microbiotix, Inc. One Innovation Dr., Worcester, MA, USA., Cardinale SC; Microbiotix, Inc. One Innovation Dr., Worcester, MA, USA., Kwasny SM; Microbiotix, Inc. One Innovation Dr., Worcester, MA, USA., Morin LR; Microbiotix, Inc. One Innovation Dr., Worcester, MA, USA., Butler MM; Microbiotix, Inc. One Innovation Dr., Worcester, MA, USA., Opperman TJ; Microbiotix, Inc. One Innovation Dr., Worcester, MA, USA., Bowlin TL; Microbiotix, Inc. One Innovation Dr., Worcester, MA, USA., Jerse A; Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA., Stagg SM; Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL, USA.; Institute of Molecular Biophysics, Florida State University, Tallahassee, FL, USA., Dunham CM; Department of Biochemistry and Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, GA, USA. cmdunha@emory.edu., Keiler KC; Department of Biochemistry & Molecular Biology, Penn State University, University Park, PA, USA. kkeiler@psu.edu.

Publikováno v: Nature communications [Nat Commun] 2021 Mar 19; Vol. 12 (1), pp. 1799. Date of Electronic Publication: 2021 Mar 19.