Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Barbay Jk"'
Synthesis and biological evaluation of novel pyridazinone-based alpha4 integrin receptor antagonists
Autor:
Yong Gong, Barbay Jk, Dennis J. Hlasta, Stephen M. Prouty, Scott A. Ballentine, Patricia Andrade-Gordon, Alexey B. Dyatkin, William Hageman, John A. Masucci, Rosemary J. Santulli, M. C. Fisher, Pamela J. Hornby, Wei He, N. H. Wallace, Bruce P. Damiano, Craig R. Schneider, Tamara A. Miskowski, Edward S. Kimball, Bruce E. Maryanoff
Publikováno v:
Journal of medicinal chemistry. 49(11)
A novel series of pyridazinone-functionalized phenylalanine analogues was prepared and evaluated for inhibition of cellular adhesion mediated by alpha4beta1/VCAM-1 and alpha4beta7/MAdCAM-1 interactions. Concise syntheses were developed and applied fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab6d43b8982876cebeb4e969ff606aa
https://pubmed.ncbi.nlm.nih.gov/16722660
https://pubmed.ncbi.nlm.nih.gov/16722660
Akademický článek
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Akademický článek
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Autor:
Tichenor MS; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Wiener JJM; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Rao NL; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Bacani GM; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Wei J; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Pooley Deckhut C; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Barbay JK; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Kreutter KD; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Chang L; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Clancy KW; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Murrey HE; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Wang W; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Ahn K; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Huber M; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Rex E; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Coe KJ; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Wu J; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Rui H; Janssen Research & Development, 4560 Jinke Road, Pudong New Area, Shanghai 201319, P. R. China., Sepassi K; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Gaudiano M; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium., Bekkers M; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium., Cornelissen I; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium., Packman K; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium., Seierstad M; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Xiouras C; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium., Bembenek SD; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Alexander R; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Milligan C; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Balasubramanian S; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Lebsack AD; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Venable JD; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Philippar U; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium., Edwards JP; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Hirst G; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2022 Nov 10; Vol. 65 (21), pp. 14326-14336. Date of Electronic Publication: 2022 Oct 31.
Autor:
Tichenor MS; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Wiener JJM; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Rao NL; Janssen Research & Development, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Pooley Deckhut C; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Barbay JK; Janssen Research & Development, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Kreutter KD; Janssen Research & Development, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Bacani GM; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Wei J; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Chang L; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Murrey HE; Janssen Research & Development, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Wang W; Janssen Research & Development, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Ahn K; Janssen Research & Development, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Huber M; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Rex E; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Coe KJ; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Wu J; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Seierstad M; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Bembenek SD; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Leonard KA; Janssen Research & Development, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Lebsack AD; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Venable JD; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Edwards JP; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
Publikováno v:
ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Apr 05; Vol. 12 (5), pp. 782-790. Date of Electronic Publication: 2021 Apr 05 (Print Publication: 2021).
Autor:
Barbay JK; Discovery Immunology, Janssen Research and Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, United States. Electronic address: kbarbay@its.jnj.com., Cummings MD; Discovery Sciences, Janssen Research and Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, United States. Electronic address: mcummin1@its.jnj.com., Abad M; Discovery Sciences, Janssen Research and Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, United States., Castro G; Discovery Immunology, Janssen Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, United States., Kreutter KD; Discovery Immunology, Janssen Research and Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, United States., Kummer DA; Discovery Immunology, Janssen Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, United States., Maharoof U; Discovery Immunology, Janssen Research and Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, United States., Milligan C; Discovery Sciences, Janssen Research and Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, United States., Nishimura R; Discovery Immunology, Janssen Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, United States., Pierce J; Discovery Immunology, Janssen Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, United States., Schalk-Hihi C; Discovery Sciences, Janssen Research and Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, United States., Spurlino J; Discovery Sciences, Janssen Research and Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, United States., Tanis VM; Discovery Immunology, Janssen Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, United States., Urbanski M; Discovery Immunology, Janssen Research and Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, United States., Venkatesan H; Discovery Immunology, Janssen Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, United States., Wang A; Discovery Immunology, Janssen Research and Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, United States., Woods C; Discovery Immunology, Janssen Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, United States., Wolin R; Discovery Immunology, Janssen Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, United States., Xue X; Discovery Immunology, Janssen Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, United States., Edwards JP; Discovery Immunology, Janssen Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, United States., Fourie AM; Discovery Immunology, Janssen Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, United States., Leonard K; Discovery Immunology, Janssen Research and Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, United States.
Publikováno v:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Dec 01; Vol. 27 (23), pp. 5277-5283. Date of Electronic Publication: 2017 Oct 16.
Autor:
Shook BC; Janssen Research & Development, LLC, Welsh and McKean Roads, PO Box 776, Spring House, PA 19477, USA. bshook@its.jnj.com, Chakravarty D, Barbay JK, Wang A, Leonard K, Alford V, Powell MT, Rassnick S, Scannevin RH, Carroll K, Wallace N, Crooke J, Ault M, Lampron L, Westover L, Rhodes K, Jackson PF
Publikováno v:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 May 01; Vol. 23 (9), pp. 2688-91. Date of Electronic Publication: 2013 Feb 27.
Autor:
Shook BC; Janssen Research and Development, L.L.C., Welsh and McKean Roads, P.O. Box 776, Spring House, Pennsylvania 19477, United States. bshook@its.jnj.com, Rassnick S, Wallace N, Crooke J, Ault M, Chakravarty D, Barbay JK, Wang A, Powell MT, Leonard K, Alford V, Scannevin RH, Carroll K, Lampron L, Westover L, Lim HK, Russell R, Branum S, Wells KM, Damon S, Youells S, Li X, Beauchamp DA, Rhodes K, Jackson PF
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2012 Feb 09; Vol. 55 (3), pp. 1402-17. Date of Electronic Publication: 2012 Jan 26.
Autor:
Shook BC; Johnson & Johnson Pharmaceutical Research and Development, L.L.C., Welsh and McKean Roads, PO Box 776, Spring House, PA 19477, United States. bshook@its.jnj.com, Rassnick S, Chakravarty D, Wallace N, Ault M, Crooke J, Barbay JK, Wang A, Leonard K, Powell MT, Alford V, Hall D, Rupert KC, Heintzelman GR, Hansen K, Bullington JL, Scannevin RH, Carroll K, Lampron L, Westover L, Russell R, Branum S, Wells K, Damon S, Youells S, Beauchamp D, Li X, Rhodes K, Jackson PF
Publikováno v:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 May 01; Vol. 20 (9), pp. 2868-71. Date of Electronic Publication: 2010 Mar 07.
Autor:
Gong Y; Johnson & Johnson Pharmaceutical Research and Development, Spring House, PA 19477-0776, USA. ygong@prdus.jnj.com, Barbay JK, Buntinx M, Li J, Wauwe JV, Claes C, Lommen GV, Hornby PJ, He W
Publikováno v:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Jul 15; Vol. 18 (14), pp. 3852-5. Date of Electronic Publication: 2008 Jun 20.