DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors.

Autor: Ostroverkhova D; Department of Pathology and Molecular Medicine, School of Medicine, Queen's University, Kingston, ON, Canada., Tyryshkin K; Department of Pathology and Molecular Medicine, School of Medicine, Queen's University, Kingston, ON, Canada., Beach AK; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA., Moore EA; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA., Masoudi-Sobhanzadeh Y; Department of Pathology and Molecular Medicine, School of Medicine, Queen's University, Kingston, ON, Canada., Barbari SR; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA., Rogozin IB; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA., Shaitan KV; Lomonosov Moscow State University, Moscow, Russia., Panchenko AR; Department of Pathology and Molecular Medicine, School of Medicine, Queen's University, Kingston, ON, Canada. Electronic address: anna.panchenko@queensu.ca., Shcherbakova PV; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: pshcherb@unmc.edu.

Publikováno v: Cell reports [Cell Rep] 2024 Jan 23; Vol. 43 (1), pp. 113655. Date of Electronic Publication: 2024 Jan 13.

Compensation for the absence of the catalytically active half of DNA polymerase ε in yeast by positively selected mutations in CDC28.

Autor: Stepchenkova EI; Laboratory of Mutagenesis and Genetic Toxicology, Vavilov Institute of General Genetics, Saint-Petersburg Branch, Russian Academy of Sciences, Saint-Petersburg 199034, Russia.; Department of Genetics and Biotechnology, Saint-Petersburg State University, Saint-Petersburg 199034, Russia.; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA., Zhuk AS; ITMO University, Saint-Petersburg 191002, Russia., Cui J; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA., Tarakhovskaya ER; Laboratory of Mutagenesis and Genetic Toxicology, Vavilov Institute of General Genetics, Saint-Petersburg Branch, Russian Academy of Sciences, Saint-Petersburg 199034, Russia.; Department of Plant Physiology and Biochemistry, Saint-Petersburg State University, Saint-Petersburg 199034, Russia., Barbari SR; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA., Shcherbakova PV; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA., Polev DE; Research Resource Center 'Biobank,' Research Park, Saint-Petersburg State University, Saint-Petersburg 198504, Russia., Fedorov R; Department of Mathematics, University of Pittsburgh, PA 15213, USA., Poliakov E; Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA., Rogozin IB; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA., Lada AG; Department of Microbiology and Molecular Genetics, University of California Davis, Davis, CA 92697, USA., Pavlov YI; Department of Genetics and Biotechnology, Saint-Petersburg State University, Saint-Petersburg 199034, Russia.; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.; Department of Microbiology and Pathology, University of Nebraska Medical Center, Omaha, NE 68198, USA.; Department of Genetics Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Publikováno v: Genetics [Genetics] 2021 Jun 24; Vol. 218 (2).

Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae .

Autor: Barbari SR; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198., Kane DP; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198., Moore EA; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198., Shcherbakova PV; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198 pshcherb@unmc.edu.

Publikováno v: G3 (Bethesda, Md.) [G3 (Bethesda)] 2018 Mar 02; Vol. 8 (3), pp. 1019-1029. Date of Electronic Publication: 2018 Mar 02.

Identification of Potential Phytochemicals Against Cyclin-Dependent Kinase 1 and Cyclin-Dependent Kinase 2: A Molecular Docking and Molecular Dynamic Approach.

Autor: PAWAR, SWARANJALI¹, SHINDE, SHALINI¹, CHAVAN, POOJA¹, RATHOD, S.¹ sanket.rathod-copk@bvp.edu.in, CHOUDHARI, P.¹, ARVINDEKAR, SNEHAL¹, PATIL, S.²

Publikováno v: Indian Journal of Pharmaceutical Sciences. Jan/Feb2024, Vol. 86 Issue 1, p322-329. 8p.

DNA 损伤修复变异与三阴性乳腺癌辅助 治疗的相关性研究.

Autor: 王雪¹, 岳健¹, 康一坤², 高崧淋², 袁芃¹ yuanpeng01@hotmail.com

Publikováno v: Chinese Journal of Oncology. Sep2023, Vol. 45 Issue 9, p787-795. 9p.