Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Barbara-Anne Martin"'
Autor:
Douglas E. Wood, Robert B. Nelson, Barbara G. Sahagan, Xingrong Liu, Lei Zhang, Nikolay Pozdnyakov, Jeffrey Van Deusen, Karl E.G. Richter, James E. Finley, Christine P. Parker, Karen J. Coffman, Michael Aaron Brodney, Barbara-Anne Martin, David D. Auperin, Joel B. Schachter, Dane R. Liston, Michael J. Karmilowicz, Tracy M. Brown, Barbara Tate, Christine E. Oborski, Sharon A. Sokolowski, Stacey L. Becker, Bronk Brian Scott, Thomas A. Lanz, Carol D. Hicks, Charles E. Nolan, Kathleen M. Wood
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2637-2640
A novel series of tetralin containing amino imidazoles, derived from modification of the corresponding phenyl acetic acid derivatives is described. Replacement of the amide led to identification of a potent series of tetralin-amino imidazoles with ro
Autor:
Kathleen M. Wood, Ping Du, Karen J. Coffman, Karl E.G. Richter, Sharon A. Sokolowski, Barbara-Anne Martin, Dane R. Liston, Barbara Tate, Douglas E. Wood, Tracy M. Brown, Michael Aaron Brodney, Carol D. Hicks, Charles E. Nolan, Nikolay Pozdnyakov, James E. Finley, Christine E. Oborski, Stacey L. Becker, Thomas A. Lanz, Kieran F. Geoghegan
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 334:269-277
PF-3084014 [(S)-2-((S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-3-ylamino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide] is a novel gamma-secretase inhibitor that reduces amyloid-beta (Abeta) production with an in vitro
Autor:
Barbara-Anne Martin, Claudine A. Louis, Adriana J. Meszaros, Jonathan S. Reichner, Balduino Mastrofrancesco, Jorge E. Albina, William L. Henry
Publikováno v:
The American Journal of Pathology. 154:1097-1104
Tissue injury initiates a temporally ordered sequence of local cellular and metabolic responses presumably necessary for successful repair. Previous investigations demonstrated that metabolic evidence for nitric oxide synthase (NOS) activity is detec
Autor:
Nikolay Pozdnyakov, Karen J. Coffman, Bronk Brian Scott, Douglas E. Wood, Xingrong Liu, Karl E.G. Richter, Dane R. Liston, James E. Finley, Sharon A. Sokolowski, Barbara Tate, Thomas A. Lanz, Michael Aaron Brodney, Christine E. Oborski, Jeffrey Van Deusen, Stacey L. Becker, Carol D. Hicks, Charles E. Nolan, Kathleen M. Wood, Michael J. Karmilowicz, Barbara-Anne Martin, Joel B. Schachter, Christine P. Parker, Robert B. Nelson, David D. Auperin, Barbara G. Sahagan, Tracy M. Brown
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(9)
The synthesis and structure–activity relationship (SAR) of a novel series of di-substituted imidazoles, derived from modification of DAPT, are described. Subsequent optimization led to identification of a highly potent series of inhibitors that con
Autor:
Chandra B. Gamlath, Barbara G. Sahagan, Kevin Cherry, Christine E. Oborski, Dane R. Liston, Charles F. Ebbinghaus, Barbara-Anne Martin, Michael L. Corman, Yuhpyng L. Chen
Publikováno v:
ChemInform. 39
The thiazole-diamide series (1) has been identified as highly potent γ-secretase inhibitors. Several representative compounds showed IC50 values of
Autor:
Christine E. Oborski, Kevin Cherry, Barbara-Anne Martin, Barbara G. Sahagan, Yuhpyng L. Chen, Michael L. Corman, Chandra B. Gamlath, Dane R. Liston, Charles F. Ebbinghaus
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(20)
The thiazole-diamide series (1) has been identified as highly potent gamma-secretase inhibitors. Several representative compounds showed IC(50) values of0.3 nM. The synthesis and SAR, as well as a radiolabeled synthesis of [(3)H]-2a, are described.