Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Barbara Wetzer"'
Autor:
Barbara Wetzer, Daniel Scherman, Christophe Masson, Nathalie Mignet, Michel Bessodes, Marie Garinot, Philippe Mailhe
Publikováno v:
Journal of Controlled Release. 99:423-434
The synthesis and properties of pH-sensitive polyethylene glycol (PEG) lipids are described. The sensitivity of these conjugates to slightly acidic pH was clearly related to the structure of the orthoester linkage involved. It was found that pH-sensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b55c51e5a0977c9543809db35a6d6b
https://doi.org/10.1016/j.jconrel.2004.07.016
https://doi.org/10.1016/j.jconrel.2004.07.016
Autor:
Mathias Lösche, Uwe B. Sleytr, Barbara Wetzer, Paul B. Howes, Dietmar Pum, Kristian Kjaer, Markus J. Weygand
Publikováno v:
The Journal of Physical Chemistry B. 106:5793-5799
Structural details of the coupling of bacterial surface (S)-layers to the phospholipid, dipalmitoylphosphatidylethanolamine (DPPE), have been characterized using X-ray and neutron reflectometry. We studied the binding andrecrystallization of S-protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70f362d5acc2adf3a3291f3d0330d4f6
https://doi.org/10.1021/jp0146418
https://doi.org/10.1021/jp0146418
Autor:
Barbara WETZER, Gerardo BYK, Marc FREDERIC, Marc AIRIAU, Francis BLANCHE, Bruno PITARD, Daniel SCHERMAN
Publikováno v:
Biochemical Journal. 356:747-756
One of the main challenges of gene therapy remains the increase of gene delivery into eukaryotic cells. We tested whether intracellular DNA release, an essential step for gene transfer, could be facilitated by using reducible cationic DNA-delivery ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::740982b46171edbbfbdf7ee46922461c
https://doi.org/10.1042/bj3560747
https://doi.org/10.1042/bj3560747
Autor:
Nathalie Mignet, Daniel Scherman, Marie Jose Egron, Nicolas Leforestier, Alain Quenot, Françoise Leclercq, Barbara Wetzer, Jean Herscovici
Publikováno v:
Organic Letters. 3:1893-1896
[see structure]. We report the synthesis of new cationic lipids. These amphiphiles present a hydrophobic domain connected to a guanidinium entity by an unsaturated glycoside scaffold. The synthetic strategy using amide or acetal linkage led to variou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82259636fd2f8bcdfc9755681bc5d251
https://doi.org/10.1021/ol0159423
https://doi.org/10.1021/ol0159423
Autor:
Barbara Wetzer, Pierre Lehn, Michelle Hauchecorne, Jean-Louis Rigaud, Bruno Pitard, Christophe Masson, Noufissa Oudrhiri, Jean-Marie Lehn, Daniel Scherman, Olivier Lambert, Eric Vivien, Jean-Pierre Vigneron
Publikováno v:
The Journal of Gene Medicine. 3:478-487
Background Colloidal stability of lipid/DNA aggregates is a major requirement for cationic lipid-mediated transfection which is particularly difficult to fulfil at the high DNA concentrations used for in vivo gene delivery. Thus, we have investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701dcaaaa9b2432cb88281e8ceccf0c4
https://doi.org/10.1002/jgm.211
https://doi.org/10.1002/jgm.211
Autor:
Barbara Wetzer, Jaqueline Friedmann, Mathias Lösche, Kristian Kjaer, Dietmar Pum, Markus J. Weygand, Paul B. Howes, Uwe B. Sleytr, Manfred Schalke
Publikováno v:
Journal of Materials Chemistry. 10:141-148
The coupling of bacterial S-layer proteins to phospholipid membranes has been studied in molecular detail with respect to, particularly, the lipid headgroups. Emphasis has been laid on two of the best characterized protein species, the S-layer protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8da1346b4cac70d6e0251b2367499643
https://doi.org/10.1039/a905196a
https://doi.org/10.1039/a905196a
Autor:
Andreas Offenhäusser, Axel Sinner, Barbara Wetzer, Wolfgang Knoll, Uwe B. Sleytr, Erika Györvary
Publikováno v:
Scopus-Elsevier
Supported lipid bilayers on planar silicon substrates have been formed using crystalline bacterial cell surface (S-layer) protein as support onto which DMPC (pure or mixture with 30 mol % cholesterol) or DPPC bilayers were deposited. Lateral diffusio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb7418266a6c3ed3dcf89a4a501a5b2
https://doi.org/10.1021/la980827v
https://doi.org/10.1021/la980827v
Autor:
Marie Jose Egron, Barbara Wetzer, Nathalie Mignet, Alain Quenot, Jean Herscovici, Daniel Scherman, Françoise Leclercq, Nicolas Leforestier
Publikováno v:
ChemInform. 32
We report the synthesis of new cationic lipids. These amphiphiles present a hydrophobic domain connected to a guanidinium entity by an unsaturated glycoside scaffold. The synthetic strategy using amide or acetal linkage led to various mono- and bicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03b665edafe56c4a49ca8c9a38e46556
https://doi.org/10.1002/chin.200150206
https://doi.org/10.1002/chin.200150206
Publikováno v:
Methods in enzymology. 373
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f6aec43dd3e91319b11b6b84c4ad8690
https://pubmed.ncbi.nlm.nih.gov/14714415
https://pubmed.ncbi.nlm.nih.gov/14714415
Publisher Summary This chapter deals with the cationic lipids developed and investigated as an alternative to viral vectors for gene therapy. They are able to associate with the DNA by ionic attraction and protect it from nucleases in biological medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25a6c75deb68cd2554ed9c16a41dfd1a
https://doi.org/10.1016/s0076-6879(03)73023-7
https://doi.org/10.1016/s0076-6879(03)73023-7
