Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Barbara W. Bernstein"'
Autor:
Jianjie Mi, Alisa E Shaw, Chi W Pak, Keifer P Walsh, Laurie S Minamide, Barbara W Bernstein, Thomas B Kuhn, James R Bamburg
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83609 (2013)
Filament bundles (rods) of cofilin and actin (1:1) form in neurites of stressed neurons where they inhibit synaptic function. Live-cell imaging of rod formation is hampered by the fact that overexpression of a chimera of wild type cofilin with a fluo
Externí odkaz:
https://doaj.org/article/6b6af92becf44f2bb4468f3c52a3554d
Autor:
James R. Bamburg, Barbara W. Bernstein
Publikováno v:
Cytoskeleton. 73:477-497
Cytoskeletal abnormalities and synaptic loss, typical of both familial and sporadic Alzheimer disease (AD), are induced by diverse stresses such as neuroinflammation, oxidative stress, and energetic stress, each of which may be initiated or enhanced
Autor:
J. R. Jensen, James R. Bamburg, Alisa E. Shaw, Michael T. Maloney, Ian T. Marsden, Barbara W. Bernstein, Kevin C. Flynn, Claire Goldsbury, Ineka T. Whiteman, O'Neil Wiggan, Laurie S. Minamide, Richard C. Davis, Chi W. Pak
Publikováno v:
Current Alzheimer Research. 7:241-250
Dephosphorylation (activation) of cofilin, an actin binding protein, is stimulated by initiators of neuronal dysfunction and degeneration including oxidative stress, excitotoxic glutamate, ischemia, and soluble forms of beta-amyloid peptide (Abeta).
Autor:
Barbara W. Bernstein, James R. Bamburg
Publikováno v:
Trends in Cell Biology. 20:187-195
Recent findings have significantly expanded our understanding of the regulation of actin depolymerizing factor (ADF)/cofilin proteins and the profound multifaceted impact that these well-established regulators of actin dynamics have on cell biology.
Autor:
James R. Bamburg, Barbara W. Bernstein
Publikováno v:
Cell Motility and the Cytoskeleton. 58:96-103
The cytoskeletal protein actin is the main building material of the ever-changing structures that underlie directed cell migration in response to external cues [Small et al., 2002]. But how the cell coordinates the disassembly of filaments and their
Publikováno v:
Radiation Research. 157:26-31
It has been known for many years that caffeine reduces or eliminates the G2-phase cell cycle delay normally seen in human HeLa cells or Chinese hamster ovary (CHO) cells after exposure to X or gamma rays. In light of our recent demonstration of a con
Autor:
Barbara W. Bernstein, James R. Bamburg
Publikováno v:
Current Biology. 20:R360-R362
SummaryMical, a redox enzyme, binds the cytoplasmic domain of the semaphorin receptor plexin A and mediates semaphorin-signaled collapse of the actin cytoskeleton. Recent work now shows that Mical's ability to bind actin filaments and destabilize the
Autor:
Michael D. Brown, Barbara W. Bernstein, Laurie S. Minamide, Elizabeth A. Soda, Kyoko Okada, John R. Jensen, James R. Bamburg, Thomas Kuhn, Peter J. Meberg
Publikováno v:
Journal of Neurobiology. 44:126-144
Growth cone motility and navigation in response to extracellular signals are regulated by actin dynamics. To better understand actin involvement in these processes we determined how and in what form actin reaches growth cones, and once there, how act
Publikováno v:
Trends in Biochemical Sciences. 25:19-23
The assembly and disassembly (i.e. turnover) of actin filaments in response to extracellular signals underlie a wide variety of basic cellular processes such as cell division, endocytosis and motility. The bulk turnover of subunits is 100-200 times f
Autor:
Hiroshi Abe, W. B. Painter, Hui Chen, Barbara W. Bernstein, James R. Bamburg, Laurie S. Minamide
Publikováno v:
Cell Motility and the Cytoskeleton. 47:319-336
The ADF/cofilin (AC) proteins are necessary for the high rates of actin filament turnover seen in vivo. Their regulation is complex enough to underlie the precision in filament dynamics needed by stimulated cells. Disassembly of actin by AC proteins