Výsledky vyhledávání - "Barbara W Young"

CCS1477: A Novel Small Molecule Inhibitor of p300/CBP Bromodomain for the Treatment of Acute Myeloid Leukaemia and Multiple Myeloma

Autor: Neil Anthony Pegg, Gary J. Spencer, Barbara W Young, Nigel Brooks, Meera Raja, Tim C. P. Somervaille

Publikováno v: Blood. 134:2560-2560

E1A binding protein (p300) and CREB binding protein (CBP) are two closely related histone acetyl transferases with oncogenic roles in acute myeloid leukaemia (AML) and multiple myeloma (MM). Here we describe the pre-clinical characterization of CCS14

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b4b4e08bac50ac92d6ebf7f634e163f
https://doi.org/10.1182/blood-2019-124707

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TLR7 stimulation of APCs results in inhibition of IL-5 through type I IFN and Notch signaling pathways in human peripheral blood mononuclear cells

Autor: Hiroyuki Matsui, Carolyn Jones, Andrew J. Leishman, Clare Murray, Susan Edwards, Mark Biffen, Hideyuki Tomizawa, Barbara W. Young

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 190(6)

TLR7 agonists modulate Th2 immune responses through mechanisms that have not been fully elucidated. Suppression of IL-5 production from Ag- or phytohemagglutinin-stimulated human PBMCs by the TLR7 antedrug AZ12441970 was mediated via type I IFN–dep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f58cd48768304cc809f9286d74b466b
https://pubmed.ncbi.nlm.nih.gov/23382558

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