Expression of Microbial Enzymes in Mammalian Astrocytes to Modulate Lactate Release

Autor: Barbara Vaccari Cardoso, Iliana Barrera, Valentina Mosienko, Alexander V. Gourine, Sergey Kasparov, Anja G. Teschemacher

Publikováno v: Brain Sciences, Vol 11, Iss 8, p 1056 (2021)

Astrocytes support and modulate neuronal activity through the release of L-lactate. The suggested roles of astrocytic lactate in the brain encompass an expanding range of vital functions, including central control of respiration and cardiovascular pe

Externí odkaz: https://doaj.org/article/4f826c2125b64a93bb57886438dc22e8

Reducing l‐lactate release from hippocampal astrocytes by intracellular oxidation increases novelty induced activity in mice

Autor: Valentina Mosienko, Sergey Kasparov, Olga Mychko, Mikhail V. Pletnikov, Anja G. Teschemacher, Barbara Vaccari Cardoso, Chantelle E. Terrillion, A. V. Shevelkin

Publikováno v: Glia

Astrocytes are in control of metabolic homeostasis in the brain and support and modulate neuronal function in various ways. Astrocyte‐derived l‐lactate (lactate) is thought to play a dual role as a metabolic and a signaling molecule in inter‐ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd8e0e088c1ff3d455e94991637fb6d
http://europepmc.org/articles/PMC8576740

Glio- and neuro-protection by prosaposin is mediated by orphan G-protein coupled receptors GPR37L1 and GPR37

Autor: Beihui Liu, Barbara Vaccari Cardoso, Anja G. Teschemacher, Daria Prokudina, Valentina Mosienko, Sergey Kasparov, M. J. Huentelman

Publikováno v: Glia
Liu, B, Mosienko, V, Vaccari Cardoso, B, Prokudina, D, Huentelman, M, Teschemacher, A & Kasparov, S 2018, ' Glio- and neuro-protection by prosaposin is mediated by orphan G-protein coupled receptors GPR37L1 and GPR37 ', Glia . https://doi.org/10.1002/glia.23480

Discovery of neuroprotective pathways is one of the major priorities for neuroscience. Astrocytes are natural neuroprotectors and it is likely that brain resilience can be enhanced by mobilizing their protective potential. Among G‐protein coupled r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8712c67f32f6849da4c7e4979acedc81
https://pubmed.ncbi.nlm.nih.gov/30260505