Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Barbara Thaler"'
Autor:
Catarina Pinto, Ksenija Slavic-Obradovic, Daniela Fürweger, Barbara Thaler, Abdallah Souabni, Sebastian Carotta, Martin Aichinger, Ulrich Reiser, Maria Antonietta Impagnatiello, Iñigo Tirapu
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106381- (2023)
Summary: Small molecule IAP antagonists - SMAC mimetics (SM) - are being developed as an anticancer therapy. SM therapy was demonstrated not only to sensitize tumor cells to TNFα-mediated cell death but also to exert immunostimulatory properties. Th
Externí odkaz:
https://doaj.org/article/68266ad8652247818e6f91fc5012f708
Autor:
Leticia Corrales, Susanne Hipp, Katharina Martin, Nicolas Sabarth, Iñigo Tirapu, Klaus Fuchs, Barbara Thaler, Christian Walterskirchen, Kathrin Bauer, Markus Fabits, Michael Bergmann, Carina Binder, Paolo ML. Chetta, Anne B. Vogt, Paul J. Adam
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Colorectal cancer (CRC) is one of the most common cancers worldwide and demands more effective treatments. We sought to identify tumor selective CRC antigens and their therapeutic potential for cytotoxic T-cell targeting by transcriptomic and immunoh
Externí odkaz:
https://doaj.org/article/4e657dd29c1a4cc39eab8fbf55b96587
Autor:
Philipp J. Hohensinner, Julia Mayer, Julia Kichbacher, Julia Kral-Pointner, Barbara Thaler, Christoph Kaun, Lena Hell, Patrick Haider, Marion Mussbacher, Johannes A. Schmid, Stefan Stojkovic, Svitlana Demyanets, Michael B. Fischer, Kurt Huber, Katharina Wöran, Christian Hengstenberg, Walter S. Speidl, Rudolf Oehler, Ingrid Pabinger, Johann Wojta
Publikováno v:
Haematologica, Vol 106, Iss 2 (2020)
Macrophages are versatile cells that can be polarized by the tissue environment to fulfill required needs. Proinflammatory polarization is associated with increased tissue degradation and propagation of inflammation whereas alternative polarization w
Externí odkaz:
https://doaj.org/article/c88174e20a0542a79f36b73e83873944
Autor:
Philipp J. Hohensinner, Adelheid Panzenböck, Robert J. Parmer, Nagyung Baik, Kurt Huber, Johann Wojta, Walter S. Speidl, Gersina Rega-Kaun, Manfred Prager, Johanna Baumgartner, Christoph Kaun, Stefan Stojkovic, Svitlana Demyanets, Barbara Thaler, Ihor Huk, Lindsey A. Miles, Michael B. Fischer
Publikováno v:
Blood. 134:561-567
Membrane-bound plasmin is used by immune cells to degrade extracellular matrices, which facilitates migration. The plasminogen receptor Plg-RKT is expressed by immune cells, including monocytes and macrophages. Among monocytes and macrophages, distin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::317bc0415f94e934b554d0b28a2fa0e3
https://doi.org/10.1182/blood.2018850420
https://doi.org/10.1182/blood.2018850420
Autor:
Walter S. Speidl, Lena Hell, Patrick Haider, Christian Schörgenhofer, Philipp J. Hohensinner, Johanna Baumgartner, Christian Hengstenberg, Michael B. Fischer, Barbara Thaler, Bernd Jilma, Johann Wojta, Kurt Huber, Konstantin A. Krychtiuk
Publikováno v:
Thrombosis and Haemostasis. 119:1394-1402
Monocytes are activated in inflammatory conditions via a variety of cytokine receptors as well as in a procoagulatory setting through thrombin, acting upon protease-activated receptors (PARs). This study investigated the expression pattern of PAR1 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7eef8138d79bc7ae73aec6edfea266a
https://doi.org/10.1055/s-0039-1692219
https://doi.org/10.1055/s-0039-1692219
Autor:
Christian Schoergenhofer, Bernd Jilma, Barbara Thaler, Georg Gelbenegger, Gernot Schabbauer, Marion Mussbacher, Petra Jilma-Stohlawetz, Nina Buchtele, Johann Wojta, Michael Schwameis
Publikováno v:
Thrombosis and Haemostasis. 118:1176-1184
The protease-activated receptor-1 (PAR-1) is critically involved in the co-activation of coagulation and inflammatory responses. Vorapaxar is a reversible, orally active, low molecular weight, competitive antagonist of PAR-1.We investigated the effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35dca05c5f7e95bc3bc6f70d5290bcab
https://doi.org/10.1055/s-0038-1655767
https://doi.org/10.1055/s-0038-1655767
Autor:
Konstantin A. Krychtiuk, Arezu Aliabadi, Barbara Thaler, Johann Wojta, Philipp J. Hohensinner, Christoph Kaun, Kurt Huber, Nikol Takacs, Andreas Zuckermann, Stefan Pfaffenberger
Publikováno v:
Apoptosis
The role of uPA in tissue remodeling and cell migration is already well established. In addition, uPA was reported to stabilize p53, a key cell cycle control, DNA repair and apoptosis initiation protein. We aimed to determine the role of uPA-uPAR sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51a421805bc572f32c593fd54f66929
http://europepmc.org/articles/PMC5486847
http://europepmc.org/articles/PMC5486847
Publikováno v:
International Journal of Cardiology. 231:47-53
Background Monocytes form an important part of the human innate immune system by taking part in inflammatory reactions. With time, monocytes have gained interest in the role they may play during the event of myocardial infarction (MI). The current pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904961025f0970dd822ebb84e254f9de
https://doi.org/10.1016/j.ijcard.2016.12.182
https://doi.org/10.1016/j.ijcard.2016.12.182
Autor:
Barbara Thaler
Publikováno v:
Wiener klinische Wochenschrift. 132:110-111
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5732e32a1d5659245746ded3d260d125
https://doi.org/10.1007/s00508-020-01620-1
https://doi.org/10.1007/s00508-020-01620-1
Autor:
Patrick Sulzgruber, Günther Laufer, Barbara Steinlechner, Tatjana Fleck, A Pilz, Lorenz Koller, J Wojta, Barbara Thaler, Alexander Niessner, Niema Kazem
Publikováno v:
European Heart Journal. 40
Background Post-operative atrial fibrillation (POAF) is assumed as a complex and multifactorial interaction of different pathogenic factors. Data suggests an inflammatory process as a main trigger of this specific type of atrial fibrillation. CD8+ T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c5acb9d98061da61e43c402917c4c99
https://doi.org/10.1093/eurheartj/ehz748.0639
https://doi.org/10.1093/eurheartj/ehz748.0639