Výsledky vyhledávání - "Barbara T. Navé"

Poor fetal nutrition causes long-term changes in expression of insulin signaling components in adipocytes

Autor: Barbara T. Navé, George Davey Smith, C. L. Wang, Peter R. Shepherd, Susan E. Ozanne, Johannes B. Prins

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 273:E46-E51

Insulin action on adipocytes was studied in the offspring of mothers who had been fed either a control (20% protein) or a low (8%)-protein diet during pregnancy and lactation. Adipocytes isolated from low-protein offspring had significantly higher ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d8362e10c1287797ab7e9d80fa335f
https://doi.org/10.1152/ajpendo.1997.273.1.e46

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Phorbol esters stimulate phosphatidylinositol 3,4,5-trisphosphate production in 3T3-L1 adipocytes: implications for stimulation of glucose transport

Autor: Kenneth Siddle, Barbara T. Navé, Peter R. Shepherd

Publikováno v: Biochemical Journal. 318:203-205

The effects of insulin and phorbol 12-myristate 13-acetate (PMA) on the levels of cellular phosphoinositides were investigated in 3T3-L1 adipocytes. Stimulation for 4 min with PMA (1 µ M) or insulin (10 nM) increased levels of PtdIns(3,4,5) P 3 appr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c3ffe37294ca1b27d898a88fac3083
https://doi.org/10.1042/bj3180203

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Emerging therapeutic targets in chronic heart failure: part I

Autor: Volker Roenicke, Stéphane Leclair, Anke Hoffmann, Michael Becker, Tania Szado, Thomas Kirsch, Oliver Stoss, Barbara T Navé, Thomas Henkel

Publikováno v: Expert opinion on therapeutic targets. 6(6)

Chronic heart failure (CHF) is a life threatening disease with an enormous medical requirement. Approximately 15 million people worldwide suffer from CHF. The prevalence will inevitably increase due to the ageing population. Nevertheless, current tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda503015923fe8e1b043cdb10e89c35
https://pubmed.ncbi.nlm.nih.gov/12472378

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Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP-kinase and phosphorylation of protein kinase-B in human skeletal muscle: implications for glucose metabolism

Autor: Christopher G. Proud, H. Wallberg-Henriksson, Jorge Rincon, E.J. Foulstone, R.J. Haigh, K. Siddle, Peter R. Shepherd, Barbara T. Navé, Juleen R. Zierath

Publikováno v: Diabetologia. 40(10)

Isolated skeletal muscle from healthy individuals was used to evaluate the role of phosphoinositide 3-kinase (PI 3-kinase) in insulin signalling pathways regulating mitogen activated protein kinase (MAP-kinase) and protein kinase-B and to investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb45a565cb5dd4c4317355bef9c9525
https://pubmed.ncbi.nlm.nih.gov/9349598

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Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting

Autor: Stephen R. Orr, Amanda C. Hayward, E M Bailyes, Barbara T. Navé, Maria A. Soos, Kenneth Siddle

The insulin receptor (IR) and type 1 insulin-like growth factor (IGF-I) receptor (IGFR) are both widely expressed in mammalian tissues, and are known to be capable of heteromeric assembly as insulin/IGF hybrid receptors, in addition to the classicall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346dfe8c060f334e1d626def3ed31dd9
https://europepmc.org/articles/PMC1218783/

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Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle

Autor: Lorraine A. Nolte, A. Paul Bevan, Kenneth Siddle, Jorge Rincon, Peter R. Shepherd, Juleen R. Zierath, Barbara T. Navé, Harriet Wallberg-Henriksson

Publikováno v: The Journal of biological chemistry. 272(30)

The role of phosphoinositide 3-kinase (PI 3-kinase) in insulin signaling was evaluated in human skeletal muscle. Insulin stimulated both antiphosphotyrosine-precipitable PI 3-kinase activity and 3-O-methylglucose transport in isolated skeletal muscle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56c8af796cdc6c15626190721424f4e
https://pubmed.ncbi.nlm.nih.gov/9228082

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Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes

Autor: R.J. Haigh, Amanda C. Hayward, K. Siddle, Peter R. Shepherd, Barbara T. Navé

To understand how the stimulation of phosphoinositide 3-kinase (PI 3-kinase) by different growth factors can activate different subsets of downstream responses, growth-factor regulation of PI 3-kinase activity at different intracellular locations was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311876cedd95e79e801730fa8490610b
https://europepmc.org/articles/PMC1217588/

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