Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Barbara Studamire"'
Autor:
Barbara Studamire, Stephen P. Goff
Publikováno v:
Viruses, Vol 2, Iss 5, Pp 1110-1145 (2010)
Retroviral infections cause a variety of cancers in animals and a number of diverse diseases in humans such as leukemia and acquired immune deficiency syndrome. Productive and efficient proviral integration is critical for retroviral function and is
Externí odkaz:
https://doaj.org/article/c5c67a91dfa64551aa42c11b44a3d347
Autor:
G. V. T. Swapna, Sriram Aiyer, Nirav Malani, Frederic D. Bushman, Matthew R. Plumb, James M. Aramini, William M. Schneider, Monica J. Roth, Mustafa H. Ghanem, Barbara Studamire, Ross C. Larue, Amit Sharma, Mamuka Kvaratskhelia, Gaetano T. Montelione
Publikováno v:
Nucleic Acids Research
We report alterations to the murine leukemia virus (MLV) integrase (IN) protein that successfully result in decreasing its integration frequency at transcription start sites and CpG islands, thereby reducing the potential for insertional activation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed26c5edf75f7ea23d034e1b3a715a52
https://doi.org/10.1093/nar/gku175
https://doi.org/10.1093/nar/gku175
Autor:
Russell L. Widom, Jacob Edelstein, Rivka Rudner, Walied Samarrai, Anita Srivastava, David Liu, Ann-Marie White, Barbara Studamire
The in vivo expression levels of four rRNA promoter pairs ( rrn p 1 p 2 ) of Bacillus subtilis were determined by employing single-copy lacZ fusions integrated at the amyE locus. The rrnO , rrnJ , rrnD , and rrnB promoters displayed unique growth rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4fa344263a0ad32cbbd8659c28f6977
https://europepmc.org/articles/PMC3021234/
https://europepmc.org/articles/PMC3021234/
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 101(25)
Recombination between moderately divergent DNA sequences is impaired compared with identical sequences. In yeast, an HO endonuclease-induced double-strand break can be repaired by single-strand annealing (SSA) between flanking homologous sequences. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ececcb282d83b4729a4b31826aa62bfd
https://pubmed.ncbi.nlm.nih.gov/15199178
https://pubmed.ncbi.nlm.nih.gov/15199178
Publikováno v:
Journal of molecular biology. 331(1)
In eukaryotes the MSH2-MSH3 and MSH2-MSH6 heterodimers initiate mismatch repair (MMR) by recognizing and binding to DNA mismatches. The MLH1-PMS1 heterodimer then interacts with the MSH proteins at or near the mismatch site and is thought to act as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ca988a7180d7c0d2b020eea6d1a7d7
https://pubmed.ncbi.nlm.nih.gov/12875840
https://pubmed.ncbi.nlm.nih.gov/12875840
In the Saccharomyces cerevisiae Msh2p-Msh6p complex, mutations that were predicted to disrupt ATP binding, ATP hydrolysis, or both activities in each subunit were created. Mutations in either subunit resulted in a mismatch repair defect, and overexpr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6dbbf153c1f061a2750f707f93651a7
https://europepmc.org/articles/PMC109340/
https://europepmc.org/articles/PMC109340/
Publikováno v:
Journal of bacteriology. 175(2)
Sequence analysis of cloned rescued DNA fragments from a Bacillus subtilis strain with an inserted recombinant plasmid in ribosomal operon rrnE revealed the presence of two tRNA genes for Met and Asp at the 3' end of the operon. Probing chromosomal D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcea3e7b67691cd5b61cb0d1affb21e2
https://pubmed.ncbi.nlm.nih.gov/8419296
https://pubmed.ncbi.nlm.nih.gov/8419296
Autor:
Barbara Studamire, Stephen P. Goff
Publikováno v:
Retrovirology, Vol 5, Iss 1, p 48 (2008)
Retrovirology
Retrovirology
Background A critical step for retroviral replication is the stable integration of the provirus into the genome of its host. The viral integrase protein is key in this essential step of the retroviral life cycle. Although the basic mechanism of integ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc3913d6d6300f39fa9f9631f5c3041
https://doi.org/10.1186/1742-4690-5-48
https://doi.org/10.1186/1742-4690-5-48