Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Barbara Stubbe"'
Autor:
Kevin Gevaert, Barbara Stubbe, Kevin Braeckmans, Marc Goethals, Stefaan Derveaux, Bruno G. De Geest, Joseph Demeester, Stefaan C. De Smedt, Joël Vandekerckhove
Publikováno v:
Advanced Functional Materials. 18:1624-1631
Proteases are important pharmaceutical targets for new drugs because of their involvement in numerous disease processes. This study evaluates whether photophysically encoded microparticles carrying fluorescently labeled protease substrates (peptides)
Autor:
Nathalie Huyghebaert, Farzaneh Fayazpour, Joseph Demeester, Bart Lucas, J.P. Remon, Kevin Braeckmans, Chris Vervaet, Stefaan Derveaux, Barbara Stubbe, S.C. De Smedt
Publikováno v:
Advanced Materials. 19:3854-3858
Autor:
Kevin Braeckmans, Barbara Stubbe, Joseph Demeester, Ferenc Horkay, S.C. De Smedt, T.G. Van Thienen
Publikováno v:
International Journal of Pharmaceutics. 337:31-39
Insight in the osmotic behavior of degrading hydrogels is of great importance in the design of biodegradable hydrogels for biomedical applications. This study compares the degradation behavior of PEG-HEMA (hydroxyethylmethacrylated polyethylene glyco
Publikováno v:
Macromolecules. 37:8739-8744
This study compares the behavior of dextran-based hydrogels that degrade through different mechanisms. The major aim is to investigate how the degradation mechanism influences their swelling pressu...
Publikováno v:
Pharmaceutical Research. 21:1732-1740
Pharmaceutical research strives to design drug delivery systems that respond to therapeutic needs. Considering the facts that physiologic parameters (e.g., heart rate, blood pressure, and plasma concentration of hormones, plasma proteins, and enzymes
Publikováno v:
Journal of Polymer Science Part B: Polymer Physics. 42:3397-3404
Degrading hydroxyethylmethacrylate-grafted dextran (dex-HEMA) hydro- gels generate a relatively sudden increase in osmotic pressure upon degradation into dextran solutions. This phenomenon is currently being examined as a possible means of developing
Autor:
S.C. De Smedt, Wim E. Hennink, Ferenc Horkay, Barbara Stubbe, Joseph Demeester, K. Braeckmans
Publikováno v:
Macromolecules. 35:2501-2505
The variation of the swelling pressure of dextran hydroxyethyl methacrylate (dex-HEMA) hydrogels is determined as a function of the degradation time. In the first stage of the degradation process a moderate increase in the swelling pressure is observ
Publikováno v:
Journal of Controlled Release. 75:103-114
This study reports on 'azo-polysaccharide gels', more specifically azo-inulin and azo-dextran gels, for colon drug delivery. Compared with azo-hydrogels which can be only degraded by reduction of the azo-groups, this study evaluates whether, in vitro
Publikováno v:
Pharmaceutical Research. 18:1593-1599
Purpose. To study the release of macromolecules of different sizes (bovine serum albumin, immunoglobulin G) from degrading (addition of dextranase) dextran methacrylate (dex-MA) hydrogels and to correlate the release with the evolution of the reholog
Autor:
Stefaan Derveaux, Bruno G. De Geest, Jo Demeester, Stefaan C. De Smedt, Chris Roelant, Marc Leblans, Barbara Stubbe
Publikováno v:
Analytical chemistry. 80(1)
The "layer-by-layer" (LbL) technology has been widely investigated for the coating of flat substrates and capsules with polyelectrolytes. In this study, LbL polyelectrolyte coatings applied at the surface of digitally encoded microcarriers were evalu