Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Barbara Steurer"'
Autor:
Barbara Steurer, Roel C. Janssens, Marit E. Geijer, Fernando Aprile-Garcia, Bart Geverts, Arjan F. Theil, Barbara Hummel, Martin E. van Royen, Bastiaan Evers, René Bernards, Adriaan B. Houtsmuller, Ritwick Sawarkar, Jurgen Marteijn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
DNA damage inhibits elongating RNA polymerase II, but also initiates genome-wide transcriptional responses. Here the authors reveal that particularly promoter-bound Pol II is degraded upon DNA damage in a GSK3 signaling-mediated response.
Externí odkaz:
https://doaj.org/article/8ae0ddc4ec8841d3a8a8b7435095a252
Autor:
Helga B. Landsverk, Lise E. Sandquist, Lilli T.E. Bay, Barbara Steurer, Coen Campsteijn, Ole J.B. Landsverk, Jurgen A. Marteijn, Eva Petermann, Laura Trinkle-Mulcahy, Randi G. Syljuåsen
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108469- (2020)
Summary: Transcription-replication (T-R) conflicts cause replication stress and loss of genome integrity. However, the transcription-related processes that restrain such conflicts are poorly understood. Here, we demonstrate that the RNA polymerase II
Externí odkaz:
https://doaj.org/article/d88cff54f29d4bef9a68867c7e0033c3
Autor:
Arjan F Theil, Julie Nonnekens, Barbara Steurer, Pierre-Olivier Mari, Jan de Wit, Charlène Lemaitre, Jurgen A Marteijn, Anja Raams, Alex Maas, Marcel Vermeij, Jeroen Essers, Jan H J Hoeijmakers, Giuseppina Giglia-Mari, Wim Vermeulen
Publikováno v:
PLoS Genetics, Vol 9, Iss 4, p e1003431 (2013)
The ten-subunit transcription factor IIH (TFIIH) plays a crucial role in transcription and nucleotide excision repair (NER). Inactivating mutations in the smallest 8-kDa TFB5/TTDA subunit cause the neurodevelopmental progeroid repair syndrome trichot
Externí odkaz:
https://doaj.org/article/7d60226eb215453780f9c39c8c311231
Autor:
Camila Gonzalo Hansen, Barbara Steurer, Roel C. Janssens, Di Zhou, Marjolein van Sluis, Hannes Lans, Jurgen A. Marteijn
Faithful transcription of eukaryotic genes by RNA polymerase II (Pol II) is essential for proper cell function. Nevertheless, the integrity of the DNA template of Pol II is continuously challenged by different sources of DNA damage, such as UV-light,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efe7c6942307ee50f041d7ec3a13a255
https://doi.org/10.1101/2023.05.17.541110
https://doi.org/10.1101/2023.05.17.541110
Autor:
Andrea Garofoli, Robert Stanton, Tabea Wiedmer, Ulrich Goldmann, Barbara Steurer, Evandro Ferrada, Alvaro Ingles-Prieto
Updated version of DMP at midterm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32d8977eddc9d37bab9c2fe573d43c46
Autor:
Andrea Garofoli, Robert Stanton, Tabea Wiedmer, Ulrich Goldmann, Barbara Steurer, Evandro Ferrada, Alvaro Ingles-Prieto
Initial version of DMP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16aae03fea47f5f0eaa4dd3da7bc03f4
Autor:
Wenzhi Gong, Richard Mitter, Wim Vermeulen, Dalton A Plummer, Chirantani Mukherjee, Marvin van Toorn, Karel Bezstarosti, Jesper Q. Svejstrup, Arjan F. Theil, Arnab Ray Chaudhuri, Anja Raams, Melanie van der Woude, John J. Wyrick, René Bernards, Yannick P Kok, Marcel A. T. M. van Vugt, Jurgen A. Marteijn, Barbara Steurer, Simona Cugusi, Adriaan B Houtsmuller, Jeroen Demmers, Shisheng Li, Joyce H.G. Lebbink, Kathiresan Selvam, Bart Geverts, Hannes Lans, Roel C. Janssens, Marit E. Geijer, Di Zhou, Bastiaan Evers, Calvin Shun Yu Lo
Publikováno v:
Nature Cell Biology, 23(6), 608-619. Nature Publishing Group
Nature cell biology
Nat Cell Biol
Nature cell biology
Nat Cell Biol
Correct transcription is crucial for life. However, DNA damage severely impedes elongating RNA polymerase II, causing transcription inhibition and transcription-replication conflicts. Cells are equipped with intricate mechanisms to counteract the sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8be2132ea5385e582a7d0be3b3d819
https://doi.org/10.1038/s41556-021-00692-z
https://doi.org/10.1038/s41556-021-00692-z
Invited presentation for the OEAD workshop: PH Fortbildung Citizen Science award 2022 Outline of the project Our Planetary Garden / Unser planetarischer Garten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf5c41f836b5f8e48df8f8723d9db80f
Autor:
René Bernards, Anja Raams, Jurgen A. Marteijn, Jesper Q. Svejstrup, Di Zhou, Arnab Ray Chaudhuri, Chirantani Mukherjee, Marvin van Toorn, Melanie van der Woude, Barbara Steurer, Arjan F. Theil, Wim Vermeulen, Joyce H.G. Lebbink, Kathiresan Selvam, Simona Cugusi, Adriaan B. Houtsmuller, Bart Geverts, Shisheng Li, Marit E. Geijer, Karel Bezstarosti, Bastiaan Evers, Hannes Lans, Jeroen Demmers, Roel C. Janssens, John J. Wyrick, Wenzhi Gong, Richard Mitter, Dalton A Plummer
Correct transcription is crucial for life. However, DNA damage severely impedes elongating RNA Polymerase II (Pol II), causing transcription inhibition and transcription-replication conflicts. Cells are equipped with intricate mechanisms to counterac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cae2bdda9091fcb8bbddab66b9eb692
https://doi.org/10.1101/2021.05.11.443558
https://doi.org/10.1101/2021.05.11.443558
Autor:
Barbara Steurer, Lilli T. E. Bay, Ole J. B. Landsverk, Laura Trinkle-Mulcahy, Coen Campsteijn, Lise E. Sandquist, Randi G. Syljuåsen, Helga B. Landsverk, Eva Petermann, Jurgen A. Marteijn
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108469-(2020)
Cell Reports, 33(9):108469. Cell Press
Cell Reports, 33(9):108469. Cell Press
Landsverk et al. show that the RNAPII S5 phosphatase complex WDR82/PNUTS-PP1 suppresses replication stress. WDR82/PNUTS-PP1 promotes degradation of RNAPII on chromatin, thereby reducing the residence time of RNAPII. Their results suggest that proper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6523b61e2fbe4751dc06031ae508e647
http://www.sciencedirect.com/science/article/pii/S2211124720314583
http://www.sciencedirect.com/science/article/pii/S2211124720314583