Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Barbara Steigenberger"'
Autor:
Lorenzo Galanti, Martina Peritore, Robert Gnügge, Elda Cannavo, Johannes Heipke, Maria Dilia Palumbieri, Barbara Steigenberger, Lorraine S. Symington, Petr Cejka, Boris Pfander
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract DNA double-strand breaks (DSBs) can be repaired by several pathways. In eukaryotes, DSB repair pathway choice occurs at the level of DNA end resection and is controlled by the cell cycle. Upon cell cycle-dependent activation, cyclin-dependen
Externí odkaz:
https://doaj.org/article/8bcb57ff610c4ff79e3b5f638390ffcf
Autor:
Xiaosong Liu, Bozidar Novak, Christian Namendorf, Barbara Steigenberger, Yaoyang Zhang, Christoph W. Turck
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109642- (2024)
Summary: Protein turnover is an important mechanism to maintain proteostasis. Long-lived proteins (LLPs) are vulnerable to lose their function due to time-accumulated damages. In this study we employed in vivo stable isotope labeling in mice from bir
Externí odkaz:
https://doaj.org/article/56f22a709b5f4854ad3a4f405ed9b170
Autor:
Julia Kolb, Vasiliki Tsata, Nora John, Kyoohyun Kim, Conrad Möckel, Gonzalo Rosso, Veronika Kurbel, Asha Parmar, Gargi Sharma, Kristina Karandasheva, Shada Abuhattum, Olga Lyraki, Timon Beck, Paul Müller, Raimund Schlüßler, Renato Frischknecht, Anja Wehner, Nicole Krombholz, Barbara Steigenberger, Dimitris Beis, Aya Takeoka, Ingmar Blümcke, Stephanie Möllmert, Kanwarpal Singh, Jochen Guck, Katja Kobow, Daniel Wehner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Extracellular matrix (ECM) deposition after central nervous system (CNS) injury leads to inhibitory scarring in humans and other mammals, whereas it facilitates axon regeneration in the zebrafish. However, the molecular basis of these differ
Externí odkaz:
https://doaj.org/article/10277ae948b34c2798d29b570c3957d7
Autor:
Shuai Qiao, Chia-Wei Lee, Dawafuti Sherpa, Jakub Chrustowicz, Jingdong Cheng, Maximilian Duennebacke, Barbara Steigenberger, Ozge Karayel, Duc Tung Vu, Susanne von Gronau, Matthias Mann, Florian Wilfling, Brenda A. Schulman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The GID E3 ligase regulates glucose-induced degradation in yeast, and key physiology. This study unveils E3 ligase regulation by reshaping the substrate binding site, blocking substrate access to ubiquitination active sites, and a Cage-like assembly.
Externí odkaz:
https://doaj.org/article/c583585898434b8aa4aef128b19aceb1
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Here the authors describe PhosID, an enrichment strategy using phosphonate-handles, that combines click chemistry and IMAC-based phospho-enrichment for quantitative proteomics analysis of newly synthesized proteins.
Externí odkaz:
https://doaj.org/article/1ccbb9aaf1384854b862b9b735371b80
Publikováno v:
ACS Central Science, Vol 5, Iss 9, Pp 1514-1522 (2019)
Externí odkaz:
https://doaj.org/article/95a766a0c4fc4b88aaab52f32bec4872
Autor:
Julia Kolb, Nora John, Kyoohyun Kim, Conrad Möckel, Gonzalo Rosso, Stephanie Möllmert, Veronika Kurbel, Asha Parmar, Gargi Sharma, Timon Beck, Paul Müller, Raimund Schlüßler, Renato Frischknecht, Anja Wehner, Nicole Krombholz, Barbara Steigenberger, Ingmar Blümcke, Kanwarpal Singh, Jochen Guck, Katja Kobow, Daniel Wehner
Extracellular matrix (ECM) deposition after central nervous system (CNS) injury leads to inhibitory scarring in mammals, whereas it facilitates axon regeneration in the zebrafish. However, the molecular basis of these different fates is not understoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acc7946e659e7f02a619098685543889
https://doi.org/10.1101/2022.11.21.517128
https://doi.org/10.1101/2022.11.21.517128
Autor:
Matthias Rotheneder, Kristina Stakyte, Erik van de Logt, Joseph D. Bartho, Katja Lammens, Yilan Fan, Aaron Alt, Brigitte Kessler, Christophe Jung, Wynand P. Roos, Barbara Steigenberger, Karl-Peter Hopfner
Publikováno v:
Molecular cell.
The DNA double-strand break repair complex Mre11-Rad50-Nbs1 (MRN) detects and nucleolytically processes DNA ends, activates the ATM kinase, and tethers DNA at break sites. How MRN can act both as nuclease and scaffold protein is not well understood.
Autor:
Barbara Steigenberger, Stephan Gruber, Markus Räschle, Claire Basquin, Michael Taschner, Ingmar Schaefer, Young-Min Soh, Richard A. Scheltema, Jérôme Basquin, Esben Lorentzen
Eukaryotic cells employ three SMC complexes to control DNA folding and topology. The Smc5/6 complex plays roles in DNA repair and in preventing the accumulation of deleterious DNA junctions. To elucidate how specific features of Smc5/6 govern these f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14e5fc2499d3c2c85c796e6e7a5dd537
https://doi.org/10.1101/2021.02.09.430422
https://doi.org/10.1101/2021.02.09.430422
Structure of the Human Signal Peptidase Complex Reveals the Determinants for Signal Peptide Cleavage
Autor:
Sem Tamara, Paulo C. T. Souza, Friedrich Förster, Siewert J. Marrink, Mariska Gröllers-Mulderij, Richard A. Scheltema, Patrick Ogrissek, Barbara Steigenberger, A. Manuel Liaci
The signal peptidase complex (SPC) is an essential membrane complex in the endoplasmic reticulum (ER), where it removes signal peptides (SPs) from a large variety of secretory pre-proteins with exquisite specificity. Although the determinants of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0dc420b52f3e9abbc464344bb1de2c9b
https://doi.org/10.1101/2020.11.11.378711
https://doi.org/10.1101/2020.11.11.378711