Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Barbara Sommerfeld"'
Autor:
J. Lucas McKay, Jonathan Nye, Felicia C. Goldstein, Barbara Sommerfeld, Yoland Smith, David Weinshenker, Stewart A. Factor
Publikováno v:
Neurobiology of Disease, Vol 179, Iss , Pp 106048- (2023)
Background: Freezing of gait (FOG) is a major cause of falling in Parkinson's disease (PD) and can be responsive or unresponsive to levodopa. Pathophysiology is poorly understood. Objective: To examine the link between noradrenergic systems, the deve
Externí odkaz:
https://doaj.org/article/1be36660667442c3ab69268f36d48aeb
Reduced Norepinephrine Transporter Binding in Parkinson’s disease with dopa Responsive Freezing Gait
Autor:
J. Lucas McKay, Jonathan Nye, Felicia C. Goldstein, Barbara Sommerfeld, Yoland Smith, David Weinshenker, Stewart A. Factor
Freezing of gait (FOG) is a major cause of falling and leads to loss of independence in Parkinson’s disease (PD). The pathophysiology of FOG is poorly understood – although there is a hypothesized link with NE systems. PD-FOG can present in levod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56cfb65ad8ba5fd19445a7b818bd83be
https://doi.org/10.1101/2022.03.14.22272365
https://doi.org/10.1101/2022.03.14.22272365
Autor:
Sahyli Perez Parra, Felicia C. Goldstein, Douglas Bernhard, J. Lucas McKay, Stewart A. Factor, Barbara Sommerfeld
Publikováno v:
npj Parkinson's Disease, Vol 5, Iss 1, Pp 1-8 (2019)
NPJ Parkinson's Disease
NPJ Parkinson's Disease
Study objectives included testing whether presumed levodopa-unresponsive freezing of gait (FOG) in Parkinson’s disease (PD) actually persists in the presence of adequate dopaminergic dosing and to investigate whether the presence of other parkinson
Autor:
Felicia C. Goldstein, J.L. McKay, Jaime M. Hatcher-Martin, Barbara Sommerfeld, W.T. Hu, Stewart A. Factor, J.C. Howell
ObjectiveTo evaluate the association of Alzheimer’s disease-related and inflammation-related cerebrospinal fluid (CSF) markers with freezing of gait (FOG) in patients with Parkinson’s disease (PD).MethodThe study population included well-characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::721f57731bc428e0d05fdc2d1c8c5e3e
https://doi.org/10.1101/2020.12.16.20248342
https://doi.org/10.1101/2020.12.16.20248342
Cerebrospinal fluid biomarkers in Parkinson's disease with freezing of gait: an exploratory analysis
Autor:
J.C. Howell, J.L. McKay, Jaime M. Hatcher-Martin, W.T. Hu, A F Pybus, Felicia C. Goldstein, L Wood, Stewart A. Factor, Barbara Sommerfeld
Publikováno v:
NPJ Parkinson's Disease
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-7 (2021)
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-7 (2021)
We explore the association between three Alzheimer’s disease-related and ten inflammation-related CSF markers and freezing of gait (FOG) in patients with Parkinson’s disease (PD). The study population includes PD patients with FOG (PD-FOG, N = 12
Autor:
Tanya Simuni, Liz Uribe, Hyunkeun Ryan Cho, Chelsea Caspell-Garcia, Christopher S Coffey, Andrew Siderowf, John Q Trojanowski, Leslie M Shaw, John Seibyl, Andrew Singleton, Arthur W Toga, Doug Galasko, Tatiana Foroud, Duygu Tosun, Kathleen Poston, Daniel Weintraub, Brit Mollenhauer, Caroline M Tanner, Karl Kieburtz, Lana M Chahine, Alyssa Reimer, Samantha J Hutten, Susan Bressman, Kenneth Marek, Vanessa Arnedo, Adrienne Clark, Mark Fraiser, Catherine Kopil, Sohini Chowdhury, Todd Sherer, Nichole Daegele, Cynthia Casaceli, Ray Dorsey, Renee Wilson, Sugi Mahes, Christina Salerno, Karen Crawford, Paola Casalin, Giulia Malferrari, Mali Gani Weisz, Avi Orr-Urtreger, Thomas Montine, Chris Baglieri, Amanda Christini, David Russell, Nabila Dahodwala, Nir Giladi, Stewart Factor, Penelope Hogarth, David Standaert, Robert Hauser, Joseph Jankovic, Marie Saint-Hilaire, Irene Richard, David Shprecher, Hubert Fernandez, Katrina Brockmann, Liana Rosenthal, Paolo Barone, Alberto Espay, Dominic Rowe, Karen Marder, Anthony Santiago, Shu-Ching Hu, Stuart Isaacson, Jean-Christophe Corvol, Javiar Ruiz Martinez, Eduardo Tolosa, Yen Tai, Marios Politis, Debra Smejdir, Linda Rees, Karen Williams, Farah Kausar, Whitney Richardson, Diana Willeke, Shawnees Peacock, Barbara Sommerfeld, Alison Freed, Katrina Wakeman, Courtney Blair, Stephanie Guthrie, Leigh Harrell, Christine Hunter, Cathi-Ann Thomas, Raymond James, Grace Zimmerman, Victoria Brown, Jennifer Mule, Ella Hilt, Kori Ribb, Susan Ainscough, Misty Wethington, Madelaine Ranola, Helen Mejia Santana, Juliana Moreno, Deborah Raymond, Krista Speketer, Lisbeth Carvajal, Stephanie Carvalo, Ioana Croitoru, Alicia Garrido, Laura Marie Payne, Veena Viswanth, Lawrence Severt, Maurizio Facheris, Holly Soares, Mark A. Mintun, Jesse Cedarbaum, Peggy Taylor, Kevin Biglan, Emily Vandenbroucke, Zulfiqar Haider Sheikh, Baris Bingol, Tanya Fischer, Pablo Sardi, Remi Forrat, Alastair Reith, Jan Egebjerg, Gabrielle Ahlberg Hillert, Barbara Saba, Chris Min, Robert Umek, Joe Mather, Susan De Santi, Anke Post, Frank Boess, Kirsten Taylor, Igor Grachev, Andreja Avbersek, Pierandrea Muglia, Kaplana Merchant, Johannes Tauscher
Publikováno v:
The Lancet. Neurology, vol 19, iss 1
Lancet Neurol
Lancet Neurol
BackgroundThe Parkinson's Progression Markers Initiative (PPMI) is an ongoing observational, longitudinal cohort study of participants with Parkinson's disease, healthy controls, and carriers of the most common Parkinson's disease-related genetic mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9491293206b421c5d364e092f50f0b5a
https://escholarship.org/uc/item/6mc189cw
https://escholarship.org/uc/item/6mc189cw
Autor:
Sahyli Perez Parra, Barbara Sommerfeld, Felicia C. Goldstein, Stewart A. Factor, J. Lucas McKay, Douglas Bernhard
ObjectiveTo demonstrate that levodopa-unresponsive freezing of gait (ONOFF-FOG), which is a disabling untreatable feature of Parkinson’s disease (PD), is distinct from responsive/OFF only FOG (OFF-FOG) and potentially has a distinct pathophysiology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e197cfde9daa2591266e5fc5a983b385
https://doi.org/10.1101/667071
https://doi.org/10.1101/667071
Autor:
Juan G. Puig, Tanya Khasnavis, Barbara Sommerfeld, Richard Chipkin, Rosa J. Torres, H.A. Jinnah
Publikováno v:
Molecular genetics and metabolism. 118(3)
Lesch-Nyhan disease (LND) is a genetic disorder that has characteristic metabolic, neurologic, and behavioral features. There are multiple behavioral problems including impulsivity, aggressiveness, and severe recurrent self-injurious behavior (SIB).
Autor:
Hyder A. Jinnah, Tanya Khasnavis, Richard Chipkin, William L. Nyhan, Gail E. Reiner, Barbara Sommerfeld
Publikováno v:
Molecular genetics and metabolism. 117(4)
Lesch-Nyhan disease (LND) is an inherited metabolic disorder characterized by the overproduction of uric acid and distinct behavioral, cognitive, and motor abnormalities. The most challenging clinical problem is self-injurious behavior (SIB), which i
Autor:
Alberto J. Espay, David J. Irwin, Arita McCoy, Madelaine Ranola, Giulia Malferrari, Angela James, Stuart Isaacson, Caroline M. Tanner, Peggy Taylor, Laura Leary, Emily Pighetti, Abigail Darin, Brit Mollenhauer, Christine Hunter, Sohini Chowdhury, Dominic B. Rowe, Danna Jennings, Andrew Siderowf, Zoltan Mari, Jon W. Yankey, Shirley Lasch, Hubert H. Fernandez, Arthur W. Toga, Ju-Hee Kang, Robert A. Hauser, Leslie M. Shaw, Daniela Berg, Diana Willeke, Katharina Gauss, John Seibyl, Keith A. Hawkins, David Standaert, Liz Uribe, Kristy J. Espay, Karen Williams, Holly A. Shill, Alice Chen-Plotkin, Sam Frank, Paola Casalin, Douglas Galasko, Werner Poewe, Cindy Casaceli, Fabienne Sprenger, Karen Crawford, Wolfgang Oertel, Joseph Jankovic, Andrew B. Singleton, Alison Scutti, Paolo Barone, Sarah Pan, Deborah Fontaine, Alice Rudolph, Barbara Sommerfeld, David Brooks, Bina Shah, Teresa Waligorska, James B. Leverenz, Matthew B. Stern, Stewart A. Factor, Karl Kieburtz, Christopher S. Coffey, John Q. Trojanowski, Penelope Hogarth, Kenneth Marek, Norbert Schuff, Susan Mendick, Linda Rees, Cathi-Ann Thomas, Marne Baca, Todd Sherer, Mark Frasier, Tanya Simuni, Stephanie Guthrie, David W. Russell, Claire Meunier, Jennifer Mule, Cheryl Deeley, Emily Flagg, Irene Richard, Chelsea Caspell
Publikováno v:
JAMA Neurology.
Importance We observed a significant correlation between cerebrospinal fluid (CSF) levels of tau proteins and α-synuclein, but not β-amyloid 1-42 (Aβ1-42), and lower concentration of CSF biomarkers, as compared with healthy controls, in a cohort o