Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Barbara Schaffran"'
Autor:
Moritz Groden, Hannah M Moessinger, Barbara Schaffran, Javier DeFelipe, Ruth Benavides-Piccione, Hermann Cuntz, Peter Jedlicka
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 2, p e1011267 (2024)
Investigating and modelling the functionality of human neurons remains challenging due to the technical limitations, resulting in scarce and incomplete 3D anatomical reconstructions. Here we used a morphological modelling approach based on optimal wi
Externí odkaz:
https://doaj.org/article/3f5d990058974b6f8ac08eb6bcb7f5c0
Autor:
Jarred M Griffin, Sonia Hingorani Jai Prakash, Till Bockemühl, Jessica M Benner, Barbara Schaffran, Victoria Moreno-Manzano, Ansgar Büschges, Frank Bradke
Publikováno v:
Brain communications 5(1), fcad005 (2023). doi:10.1093/braincomms/fcad005
Microtubule stabilization through epothilones is a promising preclinical therapy for functional recovery following spinal cord injury that stimulates axon regeneration, reduces growth-inhibitory molecule deposition and promotes functional improvement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa36aceccafe34765c3d639df66c999f
https://pub.dzne.de/record/249930
https://pub.dzne.de/record/249930
Autor:
Telma E. Santos, Marcy Zenobi-Wong, Barbara Schaffran, Nicolas Broguiere, Frank Bradke, Liane Meyn
Publikováno v:
Cell Reports, 32 (3)
Cell reports 32(3), 107907 (2020). doi:10.1016/j.celrep.2020.107907
Cell reports 32(3), 107907 (2020). doi:10.1016/j.celrep.2020.107907
During development of the central nervous system (CNS), neurons polarize and rapidly extend their axons to assemble neuronal circuits. The growth cone leads the axon to its target and drives axon growth. Here, we explored the mechanisms underlying ax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a3eaddbb3390b73b5bbfc3ca944dd2
Autor:
Cordelia Imig, Jisoo Kim, Max Schelski, Nils Brose, Andreas Husch, Brett J. Hilton, Johannes Alexander Müller, Emily R. Burnside, Frank Bradke, Susanne Schoch, Sebastian Dupraz, Tien-chen Lin, Barbara Schaffran
Publikováno v:
Neuron
Neuron 110(1), 51-69.e7 (2022). doi:10.1016/j.neuron.2021.10.007
Neuron 110(1), 51-69.e7 (2022). doi:10.1016/j.neuron.2021.10.007
Summary Axons in the adult mammalian central nervous system fail to regenerate after spinal cord injury. Neurons lose their capacity to regenerate during development, but the intracellular processes underlying this loss are unclear. We found that cri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae16f8f31562c8af3b37703206e090d
http://europepmc.org/articles/PMC8730507
http://europepmc.org/articles/PMC8730507
Autor:
Sina Stern, Kevin C. Flynn, Michele Curcio, Walter Witke, Brett J. Hilton, Christine B. Gurniak, Frank Bradke, Barbara Schaffran, Molly J.E. Larson, Claudia J. Laskowski, Sebastian Dupraz, Andrea Tedeschi, Telma E. Santos
Publikováno v:
Neuron 103(6), 1073-1085.e6 (2019). doi:10.1016/j.neuron.2019.07.007
Summary Injured axons fail to regenerate in the adult CNS, which contrasts with their vigorous growth during embryonic development. We explored the potential of re-initiating axon extension after injury by reactivating the molecular mechanisms that d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07de3102c075dac51ac6dc9b6a076d7
https://pubmed.ncbi.nlm.nih.gov/31557454
https://pubmed.ncbi.nlm.nih.gov/31557454
Autor:
Barbara Schaffran, Frank Bradke
Publikováno v:
Experimental neurology 313, 135-136 (2019). doi:10.1016/j.expneurol.2018.12.010
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0315e3086ece8fd37318b6148542b28
https://pub.dzne.de/record/140465
https://pub.dzne.de/record/140465
Publikováno v:
Experimental neurology 317, 110-118 (2019). doi:10.1016/j.expneurol.2019.02.010
Axons in the adult mammalian brain and spinal cord fail to regenerate upon lesion. In vivo imaging serves as a tool to investigate the immediate response of axons to injury and how the same injured axons behave over time. Here, we describe the dynami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d84757b2e2db66095b2416faf8305bd3
https://pubmed.ncbi.nlm.nih.gov/30794766
https://pubmed.ncbi.nlm.nih.gov/30794766
Autor:
Gaia Tavosanis, Tomke Stürner, Maria Nemethova, Sven Bogdan, Vic Small, Jan Mueller, Yun Zhang, Anastasia Tatarnikova, Barbara Schaffran, Hermann Cuntz
Publikováno v:
Development
Development 146(7), dev171397 (2019). doi:10.1242/dev.171397
Development
The formation of neuronal dendrite branches is fundamental for the wiring and function of the nervous system. Indeed, dendrite branching enhances the coverage of the neuron's receptive field and modulates the initial processing of incoming stimuli. C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f9d9bcadbf6e0a0370fd92923c3a70
https://pubmed.ncbi.nlm.nih.gov/30910826
https://pubmed.ncbi.nlm.nih.gov/30910826