Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Barbara Schacher"'
Autor:
Tiedt, Ralph, King, Frederick J., Stamm, Christelle, Niederst, Matthew J., Delach, Scott, Zumstein-Mecker, Sabine, Meltzer, Jodi, Mulford, Iain J., Labrot, Emma, Engstler, Barbara Schacher, Baltschukat, Sabrina, Kerr, Grainne, Golji, Javad, Wyss, Daniel, Schnell, Christian, Ainscow, Edward, Engelman, Jeffrey A., Sellers, William R., Barretina, Jordi, Caponigro, Giordano, Porta, Diana Graus
Publikováno v:
In Cell Reports 25 April 2023 42(4)
Autor:
Andrew X. Zhu, Nabeel Bardeesy, Ryan B. Corcoran, Dejan Juric, Alberto Bardelli, Ralph Tiedt, Diana Graus Porta, Gad Getz, A. John Iafrate, James R. Stone, David P. Ryan, Pascal Furet, Christelle Stamm, Louise Barys, Barbara Schacher-Engstler, Sabrina Baltschukat, Joseph M. Gurski, Emily E. Van Seventer, Jiaoyuan Elisabeth Sun, Laura Henderson, Stephanie Reyes, Benedetta Mussolin, Avinash Kambadakone, Vikram Deshpande, Phuong Vu, Jochen K. Lennerz, Leanne G. Ahronian, Ignaty Leshchiner, Giulia Siravegna, Leah Y. Liu, Supriya K. Saha, Lipika Goyal
Complete Data for Genetic Analysis of ctDNA and Tumor Tissue for All Samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259d7240a0c496326f717ca14ca60e36
https://doi.org/10.1158/2159-8290.22531277.v1
https://doi.org/10.1158/2159-8290.22531277.v1
Autor:
Andrew X. Zhu, Nabeel Bardeesy, Ryan B. Corcoran, Dejan Juric, Alberto Bardelli, Ralph Tiedt, Diana Graus Porta, Gad Getz, A. John Iafrate, James R. Stone, David P. Ryan, Pascal Furet, Christelle Stamm, Louise Barys, Barbara Schacher-Engstler, Sabrina Baltschukat, Joseph M. Gurski, Emily E. Van Seventer, Jiaoyuan Elisabeth Sun, Laura Henderson, Stephanie Reyes, Benedetta Mussolin, Avinash Kambadakone, Vikram Deshpande, Phuong Vu, Jochen K. Lennerz, Leanne G. Ahronian, Ignaty Leshchiner, Giulia Siravegna, Leah Y. Liu, Supriya K. Saha, Lipika Goyal
Supplementary Figure S1. Confirmation of secondary point mutation in FGFR2-ZMYM4 allele. Supplementary Figure S2. Homology between FGFR2 and FGFR3 proteins. Supplementary Figure S3. FGFR2-OPTN fusion detected in all autopsy lesions. Supplementary Fig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a948c1840bf99757e3637d1d57bc6518
https://doi.org/10.1158/2159-8290.22531280
https://doi.org/10.1158/2159-8290.22531280
Autor:
Ralph Tiedt, Joseph Schoepfer, Francesco Hofmann, William R. Sellers, Pascal Furet, Youzhen Wang, Hyo-Eun Carrie Bhang, Matthew T. DiMare, Jinsheng Liang, Hui Qin Wang, Angela Tam, Huai-Xiang Hao, Alan Huang, Barbara Schacher Engstler, Sabrina Baltschukat
Purpose:The selective MET inhibitor capmatinib is being investigated in multiple clinical trials, both as a single agent and in combination. Here, we describe the preclinical data of capmatinib, which supported the clinical biomarker strategy for rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883dd25b7a402997021c6005fee7ea4e
https://doi.org/10.1158/1078-0432.c.6526665
https://doi.org/10.1158/1078-0432.c.6526665
Autor:
Ralph Tiedt, Joseph Schoepfer, Francesco Hofmann, William R. Sellers, Pascal Furet, Youzhen Wang, Hyo-Eun Carrie Bhang, Matthew T. DiMare, Jinsheng Liang, Hui Qin Wang, Angela Tam, Huai-Xiang Hao, Alan Huang, Barbara Schacher Engstler, Sabrina Baltschukat
Supplementary text and figures Supplementary Figure 1 A, visualization of the "inflection point" (or EC50) and "Amax" parameters that are shown in Fig. 2A. B, HGF mRNA expression (by RNA-seq) vs HGF protein in culture supernatant for 76 cancer cell l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f08e9bb5565b6c1a2d353ed618dbee
https://doi.org/10.1158/1078-0432.22467504.v1
https://doi.org/10.1158/1078-0432.22467504.v1
Autor:
Ralph Tiedt, Joseph Schoepfer, Francesco Hofmann, William R. Sellers, Pascal Furet, Youzhen Wang, Hyo-Eun Carrie Bhang, Matthew T. DiMare, Jinsheng Liang, Hui Qin Wang, Angela Tam, Huai-Xiang Hao, Alan Huang, Barbara Schacher Engstler, Sabrina Baltschukat
Supplementary Table 1. IC50 values for capmatinib obtained in BaF3 TRP-MET cells and mutant variants as indicated after 3-day proliferation assays with a resazurin readout. MET kinase domain mutations were either generated by site-directed mutagenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41afa4c7c0951cab62eef31fa76d9f7d
https://doi.org/10.1158/1078-0432.22467501
https://doi.org/10.1158/1078-0432.22467501
Akademický článek
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Autor:
Ralph Tiedt, Frederick J. King, Christelle Stamm, Matthew J. Niederst, Scott Delach, Sabine Zumstein-Mecker, Jodi Meltzer, Iain J. Mulford, Emma Labrot, Barbara Schacher Engstler, Sabrina Baltschukat, Grainne Kerr, Javad Golji, Daniel Wyss, Christian Schnell, Edward Ainscow, Jeffrey A. Engelman, William R. Sellers, Jordi Barretina, Giordano Caponigro, Diana Graus Porta
Publikováno v:
Cell Reports. 42:112297
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c11793b458d9a0ed1745c05a515894b
https://doi.org/10.1016/j.celrep.2023.112297
https://doi.org/10.1016/j.celrep.2023.112297
Autor:
Swann Gaulis, Lina Schukur, Leon Hellmann, Vanessa Cornacchione, Ulrike Naumann, Christoph Gaul, Ralph Tiedt, Francesco Hofmann, Louise Barys, Eric Billy, Elisabetta Traggiai, Sebastian Bergling, Moriko Ito, Ying Lin, Antoine de Weck, Grainne Kerr, Barbara Schacher Engstler, David A. Ruddy, Selina Jansky, Caroline Dafflon, Andreas Weiss, Frédéric Stauffer, Karen Kapur
Publikováno v:
Oncotarget
The histone 3 lysine 79 (H3K79) methyltransferase (HMT) DOT1L is known to play a critical role for growth and survival of MLL-rearranged leukemia. Serendipitous observations during high-throughput drug screens indicated that the use of DOT1L inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d34b52a22b6f0483ff80e96d4167efc
http://europepmc.org/articles/PMC7082114
http://europepmc.org/articles/PMC7082114
Autor:
Joseph Schoepfer, Pascal Furet, Jinsheng Liang, Matthew T. DiMare, William R. Sellers, Hui Qin Wang, Alan Huang, Huaixiang Hao, Angela Tam, Ralph Tiedt, Youzhen Wang, Sabrina Baltschukat, Francesco Hofmann, Hyo-eun C. Bhang, Barbara Schacher Engstler
Publikováno v:
Clinical Cancer Research. 25:3164-3175
Purpose: The selective MET inhibitor capmatinib is being investigated in multiple clinical trials, both as a single agent and in combination. Here, we describe the preclinical data of capmatinib, which supported the clinical biomarker strategy for ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e06bd51b95e52cb3889bb84b882be9
https://doi.org/10.1158/1078-0432.ccr-18-2814
https://doi.org/10.1158/1078-0432.ccr-18-2814