Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Barbara Satin"'
Autor:
Giorgio Palù, Barbara Satin, Howard S. Marsden, Timothy R. Hirst, Emanuele Papini, Arianna Loregian
Publikováno v:
Proceedings of the National Academy of Sciences. 96:5221-5226
We report an intracellular peptide delivery system capable of targeting specific cellular compartments. In the model system we constructed a chimeric protein consisting of the nontoxic B subunit of Escherichia coli heat-labile enterotoxin (EtxB) fuse
Autor:
Barbara Satin, Rino Rappuoli, Beatrice Aricò, M. De Bernard, Maurizio Molinari, Cesare Montecucco, J. R. Telford, Emanuele Papini, Carmela Galli
Publikováno v:
Folia Microbiologica. 43:279-284
Cells treated with the VacA toxin from Helicobacter pylori develop large membrane-bound vacuoles that originate from the late endocytotic pathway. Using different experimental approaches, we showed that VacA can induce vacuoles by acting within the c
Autor:
Cesare Montecucco, Emanuele Papini, S. B. Sato, E. Gottardi, Rino Rappuoli, Paola Massari, John L. Telford, Barbara Satin, M. De Bernard
Publikováno v:
Journal of Medical Microbiology. 45:84-89
Cytotoxic strains of Helicobacter pylori cause an intense vacuolar degeneration of cells, due to the enlargement of late endosomes in the presence of membrane permeant weak bases. Bafilomycins, specific inhibitors of the vacuolar-type (V-) ATPase pro
Autor:
Giuseppe Del Giudice, Rino Rappuoli, Carlo Laudanna, Filippo Rossi, Fiorella Tonello, Dermot Kelleher, Cesare Montecucco, Barbara Satin, Stefano Dusi, Vittorina Della Bianca
Publikováno v:
The Journal of Experimental Medicine
Helicobacter pylori infection induces the appearance of inflammatory infiltrates, consisting mainly of neutrophils and monocytes, in the human gastric mucosa. A bacterial protein with neutrophil activating activity (HP-NAP) has been previously identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2a935cabbfa6545ae2aa97626e2f22
http://hdl.handle.net/11562/307748
http://hdl.handle.net/11562/307748
Autor:
William G. Dundon, Rino Rappuoli, Giuseppe Del Giudice, Barbara Satin, Fiorella Tonello, Guido Grandi, Maurizio Molinari, Cesare Montecucco, Giuseppe Tognon
Publikováno v:
Molecular microbiology. 34(2)
The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a major 17 kDa antigen of the immune response of infected individuals. Amino acid sequence comparison indicated a high similarity between HP-NAP and both bacterial DNA-protecting pr
Autor:
Barbara Satin, Mario Zoratti, Ildikò Szabò, Francesco Tombola, Sandra Brutsche, John L. Telford, Cesare Montecucco, Rino Rappuoli, Monica Moschioni, Emanuele Papini
The vacuolating toxin VacA, a major determinant of Helicobacter pylori-associated gastric diseases, forms anion-selective channels in artificial planar lipid bilayers. Here we show that VacA increases the anion permeability of the HeLa cell plasma me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcabd0408af19a4833e0e46598f3fa0c
http://hdl.handle.net/11577/2458783
http://hdl.handle.net/11577/2458783
Autor:
Rino Rappuoli, Barbara Satin, M. De Bernard, John L. Telford, Cesare Montecucco, Emanuele Papini, Nathalie Norais
The effects of the vacuolating toxin (VacA) released by pathogenic strains of Helicobacter pylori on several polarized epithelial monolayers were investigated. Trans-epithelial electric resistance (TER) of monolayers formed by canine kidney MDCK I, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a55bd1495fa788c613fd04c8a010a93a
http://hdl.handle.net/11577/2454222
http://hdl.handle.net/11577/2454222
Autor:
Rino Rappuoli, Roberto Manetti, Emanuele Papini, Barbara Satin, Cesare Montecucco, Marina de Bernard, John L. Telford, Marino Zerial, Cecilia Bucci
Publikováno v:
The EMBO journal. 16(1)
The VacA cytotoxin, produced by toxigenic strains of Helicobacter pylori, induces the formation of large vacuoles highly enriched in the small GTPase rab7. To probe the role of rab7 in vacuolization, HeLa cells were transfected with a series of rab m
Autor:
John Telford, Emanuele Papini, Rino Rappuoli, Marta Murgia, Cesare Montecucco, Barbara Satin, Nathalie Norais
The effect of vacuolating toxin (VacA) fromHelicobacter pylori on endosomal and lysosomal functions was studied by following procathepsin D maturation and epidermal growth factor (EGF) degradation in HeLa cells exposed to the toxin. VacA inhibited th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d16e8d79f325550d4e34d202649bb0b
http://hdl.handle.net/11577/2467035
http://hdl.handle.net/11577/2467035