Zobrazeno 1 - 10
of 380
pro vyhledávání: '"Barbara S. Slusher"'
Autor:
Laura Hüser, Yash Chhabra, Olesia Gololobova, Vania Wang, Guanshu Liu, Agrani Dixit, Murilo Ramos Rocha, Elizabeth I. Harper, Mitchell E. Fane, Gloria E. Marino-Bravante, Daniel J. Zabransky, Kathy Q. Cai, Jochen Utikal, Barbara S. Slusher, Jeremy Walston, Evan J. Lipson, Kenneth W. Witwer, Ashani T. Weeraratna
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114721- (2024)
Summary: Advancing age is a negative prognostic factor for cutaneous melanoma. However, the role of extracellular vesicles (EVs) within the melanoma tumor microenvironment (TME) has remained unexplored in the context of aging. While the size and morp
Externí odkaz:
https://doaj.org/article/cc61c2bf190f43668f9e6e6022b1b7fe
Autor:
Carolyn Tallon, Benjamin J. Bell, Medhinee M. Malvankar, Pragney Deme, Carlos Nogueras-Ortiz, Erden Eren, Ajit G. Thomas, Kristen R. Hollinger, Arindom Pal, Maja Mustapic, Meixiang Huang, Kaleem Coleman, Tawnjerae R. Joe, Rana Rais, Norman J. Haughey, Dimitrios Kapogiannis, Barbara S. Slusher
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-20 (2023)
Abstract Background Cognitive decline in Alzheimer’s disease (AD) is associated with hyperphosphorylated tau (pTau) propagation between neurons along synaptically connected networks, in part via extracellular vesicles (EVs). EV biogenesis is trigge
Externí odkaz:
https://doaj.org/article/d163368f208644598366636e9b045806
Autor:
Sadiya Parveen, Jessica Shen, Shichun Lun, Liang Zhao, Jesse Alt, Benjamin Koleske, Robert D. Leone, Rana Rais, Jonathan D. Powell, John R. Murphy, Barbara S. Slusher, William R. Bishai
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract As one of the most successful human pathogens, Mycobacterium tuberculosis (Mtb) has evolved a diverse array of determinants to subvert host immunity and alter host metabolic patterns. However, the mechanisms of pathogen interference with hos
Externí odkaz:
https://doaj.org/article/5ee43a946d644d098c99d5f9a66e0bac
Autor:
Kyungho Lee, Elizabeth A. Thompson, Sepideh Gharaie, Chirag H. Patel, Johanna T. Kurzhagen, Phillip M. Pierorazio, Lois J. Arend, Ajit G. Thomas, Sanjeev Noel, Barbara S. Slusher, Hamid Rabb
Publikováno v:
JCI Insight, Vol 8, Iss 12 (2023)
T cells play an important role in acute kidney injury (AKI). Metabolic programming of T cells regulates their function, is a rapidly emerging field, and is unknown in AKI. We induced ischemic AKI in C57BL/6J mice and collected kidneys and spleens at
Externí odkaz:
https://doaj.org/article/ab487db4fbcf47a9b1dfc8335f75d4e6
Autor:
Ashlyn Parkhurst, Sabrina Z. Wang, Tyler R. Findlay, Kristen J. Malebranche, Arman Odabas, Jesse Alt, Micah J. Maxwell, Harpreet Kaur, Cody J. Peer, William D. Figg, Katherine E. Warren, Barbara S. Slusher, Charles G. Eberhart, Eric H. Raabe, Jeffrey A. Rubens
Publikováno v:
Cell Death and Disease, Vol 13, Iss 4, Pp 1-14 (2022)
Abstract Atypical teratoid/rhabdoid tumors (AT/RT) are the most common malignant brain tumors of infancy and have a dismal 4-year event-free survival (EFS) of 37%. We have previously shown that mTOR activation contributes to AT/RT’s aggressive grow
Externí odkaz:
https://doaj.org/article/10b90ebb273a45c786ac0a49aa2935b6
Autor:
Meixiang Huang, Carolyn Tallon, Xiaolei Zhu, Kaitlyn D. J. Huizar, Silvia Picciolini, Ajit G. Thomas, Lukas Tenora, Wathsala Liyanage, Francesca Rodà, Alice Gualerzi, Rangaramanujam M. Kannan, Marzia Bedoni, Rana Rais, Barbara S. Slusher
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2364 (2023)
The progression of Alzheimer’s disease (AD) correlates with the propagation of hyperphosphorylated tau (pTau) from the entorhinal cortex to the hippocampus and neocortex. Neutral sphingomyelinase2 (nSMase2) is critical in the biosynthesis of extrac
Externí odkaz:
https://doaj.org/article/fe040374b1a6452caae30f8f89b5eac6
Autor:
Sehmus Tohumeken, Pragney Deme, Seung Wan Yoo, Sujasha Gupta, Rana Rais, Barbara S. Slusher, Norman J. Haughey
Publikováno v:
Neurobiology of Disease, Vol 177, Iss , Pp 105987- (2023)
Extracellular vesicles (EVs) have been proposed to regulate the deposition of Aβ. Multiple publications have shown that APP, amyloid processing enzymes and Aβ peptides are associated with EVs. However, very little Aβ is associated with EVs compare
Externí odkaz:
https://doaj.org/article/9466fab8fdb04fdba31a3bc294aee098
Autor:
Mofei Huang, Donghai Xiong, Jing Pan, Qi Zhang, Shizuko Sei, Robert H. Shoemaker, Ronald A. Lubet, Luis M. Montuenga, Yian Wang, Barbara S. Slusher, Ming You
Publikováno v:
Advanced Science, Vol 9, Iss 26, Pp n/a-n/a (2022)
Abstract Lung cancer is the leading cause of cancer death worldwide. Vaccination against EGFR can be one of the venues to prevent lung cancer. Blocking glutamine metabolism has been shown to improve anticancer immunity. Here, the authors report that
Externí odkaz:
https://doaj.org/article/9cefa07a6ed841a685c42978f76082d2
Autor:
Benjamin J. Bell, Kristen R. Hollinger, Pragney Deme, Shinji Sakamoto, Yuto Hasegawa, David Volsky, Atsushi Kamiya, Norman Haughey, Xiaolei Zhu, Barbara S. Slusher
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 23, Iss , Pp 100478- (2022)
Combined antiretroviral therapy ushered an era of survivable HIV infection in which people living with HIV (PLH) conduct normal life activities and enjoy measurably extended lifespans. However, despite viral control, PLH often experience a variety of
Externí odkaz:
https://doaj.org/article/0850c2e7117c4dc59e642809a5571c0e
Autor:
Xiaolei Zhu, Kristen R. Hollinger, Yiyao Huang, Alejandra Borjabad, Boe-Hyun Kim, Tanina Arab, Ajit G. Thomas, Mohammed Moniruzzaman, Lyndah Lovell, Andrey Turchinovich, Kenneth W. Witwer, David J. Volsky, Norman J. Haughey, Barbara S. Slusher
Publikováno v:
Neurobiology of Disease, Vol 169, Iss , Pp 105734- (2022)
People living with HIV (PLH) have significantly higher rates of cognitive impairment (CI) and major depressive disorder (MDD) versus the general population. The enzyme neutral sphingomyelinase 2 (nSMase2) is involved in the biogenesis of ceramide and
Externí odkaz:
https://doaj.org/article/dafd878bacf3408985cbb67f41a0b5db